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BEHAVIORAL EPIGENETICS AND THE BUILT ENVIRONMENT

行为表观遗传学和建筑环境

基本信息

批准号：
2019799
负责人：
Michael Goodisman
金额：
$ 110.29万
依托单位：
Georgia Tech Research Corporation
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2024-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=2019799&HistoricalAwards=false
关键词：
BEHAVIORAL EPIGENETICS BUILT ENVIRONMENT

项目摘要

Many animal societies build structures that are fundamentally important to their survival and success. For example, human societies build, live, and work within houses and buildings that provide protection from the environment. However, the effects of built structures on behavioral and cognitive processes of social groups remain poorly understood. This research program attempts to understand how the built environment affects behavior and brain function in highly social animals. The research team will use fire ants as models to study the effects of nest structure on cognition and social behavior. The research program will determine how individuals work together to build structures using collective behaviors. The investigators will also study how different environments affect social cognition by examining changes in brain activity of ants in distinct environments. Finally, the team will determine how colony function changes in different settings by challenging ants to live in experimentally fabricated nests that differ in physical organization. This program will also broaden the impact of the proposed studies by promoting teaching, training, and learning activities throughout the city of Atlanta. In addition, the research will have important applied aspects by furthering our understanding of traffic and movement in complex landscapes, and by providing important information about the behavior of a widespread pest insect. Overall, this project combines behavioral, genetic, technological, and physical approaches to understanding the effects of the built environment on society function and social cognition. The success of highly social species, such as social insects, relies critically on the construction of nests. However, little is known about how nest structure affects collective behavior and the molecular processes associated with cognition. The goal of this proposal is to gain a greater understanding of the behavioral and epigenetic consequences of nest construction and living in insect societies. The research team will first study how collective building behaviors emerge from individual actions. This will provide insight into how individual behaviors successfully lead to group activities. Second, the investigators will determine how the social environment affects epigenetic processes in the brain. Patterns of DNA methylation of ants subjected to different biological and physical environments will reveal how epigenetic information in the brain is associated with changes in gene expression. These experiments will demonstrate how epigenetic information is linked to gene activity under different social conditions. Finally, the research team will determine how the built environment affects collective behaviors. These studies will demonstrate how different physical structures affect social interactions, perception, and gene activity in the brain. Overall, this program investigates the link between cognition, social behavior, and the built environment. The research will ultimately initiate a new, interdisciplinary research direction aimed at understanding molecular processes affecting social behavior and construction by social groups.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

许多动物社会建立的结构对其生存和成功至关重要。例如，人类社会在提供环境保护的房屋和建筑物内建造、生活和工作。然而，建筑结构对社会群体行为和认知过程的影响仍然知之甚少。该研究项目试图了解建筑环境如何影响高度社会化动物的行为和大脑功能。研究小组将使用火蚁作为模型，研究巢穴结构对认知和社会行为的影响。该研究计划将确定个人如何共同努力，利用集体行为构建结构。研究人员还将通过检查不同环境中蚂蚁大脑活动的变化来研究不同环境如何影响社会认知。最后，研究小组将通过挑战蚂蚁生活在物理组织不同的实验制造的巢穴中来确定不同环境下群体功能的变化。该计划还将通过促进整个亚特兰大市的教学、培训和学习活动来扩大拟议研究的影响。此外，通过进一步了解复杂景观中的交通和运动，并提供有关广泛传播的害虫行为的重要信息，该研究将具有重要的应用价值。总体而言，该项目结合了行为、遗传、技术和物理方法来了解建筑环境对社会功能和社会认知的影响。高度社会化的物种（例如社会性昆虫）的成功很大程度上依赖于巢穴的建造。然而，人们对巢结构如何影响集体行为以及与认知相关的分子过程知之甚少。该提案的目标是更好地了解昆虫社会中筑巢和生活的行为和表观遗传后果。研究小组将首先研究集体建筑行为如何从个人行为中产生。这将深入了解个人行为如何成功引导群体活动。其次，研究人员将确定社会环境如何影响大脑的表观遗传过程。经历不同生物和物理环境的蚂蚁的 DNA 甲基化模式将揭示大脑中的表观遗传信息如何与基因表达的变化相关。这些实验将证明表观遗传信息如何在不同的社会条件下与基因活动联系起来。最后，研究团队将确定建筑环境如何影响集体行为。这些研究将证明不同的身体结构如何影响社交互动、感知和大脑中的基因活动。总体而言，该项目研究了认知、社会行为和建筑环境之间的联系。该研究最终将启动一个新的跨学科研究方向，旨在了解影响社会行为和社会群体构建的分子过程。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Toward Task Capable Active Matter: Learning to Avoid Clogging in Confined Collectives via Collisions

迈向具有任务能力的活性物质：学习避免通过碰撞在有限的集体中发生堵塞

DOI：
10.3389/fphy.2022.735667
发表时间：
2022
期刊：
Frontiers in Physics
影响因子：
3.1
作者：
Aina, Kehinde O.;Avinery, Ram;Kuan, Hui-Shun;Betterton, Meredith D.;Goodisman, Michael A.;Goldman, Daniel I.
通讯作者：
Goldman, Daniel I.

Agitated ants: regulation and self-organization of incipient nest excavation via collisional cues