A Multi-institutional Course-Based Undergraduate Research Experience in Genetics

多机构基于课程的遗传学本科研究经验

• 批准号: 2021146
• 负责人: Jacob Kagey
• 金额: $ 30万
• 依托单位: University of Detroit Mercy
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-10-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2021146&HistoricalAwards=false
• 关键词: Multi; institutional; Course; Based; Undergraduate

This project aims to serve the national interest by increasing undergraduate students’ participation in authentic STEM research. Research experiences are known to improve student performance and retention in STEM classes and majors. However, research opportunities can be limited and inequitably available. As a result, many institutions are developing course-based undergraduate research experiences (CUREs) in which all students in a course participate in a research project. This proposal aspires to develop a national consortium of undergraduate laboratory courses that implement a CURE based on the analysis of genetic mutations in the fruitfly. The project, called Fly-CURE, allows students to engage in authentic, inquiry-based research by mapping the location of mutations in the fruitfly genome and studying the mutations’ anatomical and behavioral effects. Fly-CURE is currently active in seven institutions. The project intends to expand Fly-CURE to include a network of 20 institutions. The plans for expansion are targeted to institutions, such as community colleges, that have limited capacity to provide their students with research experiences. The project intends to hold annual workshops for faculty and to pair experienced Fly-CURE faculty with novice faculty, to support and guide new faculty as they establish Fly-CURE on their campuses. As Fly-CURE expands, the project team plans to gather information about how participating in Fly-CURE affects student performance, and to compare this performance with that of students enrolled in traditional genetics courses without CUREs.CUREs transform traditional undergraduate laboratory courses into places where undergraduates can participate in an authentic research project. Providing students with authentic research experiences as undergraduates has been demonstrated to have lasting impacts on students’ knowledge and attitudes toward research and can positively impact the number of students from underrepresented groups pursuing STEM degrees. Two major obstacles stand in the way of more widespread CURE implementation. First is the creation of a sustainable research project that can be completed by undergraduates in a classroom lab setting, and the second is the development of a CURE project that exposes students to a similar spectrum of learning objectives as a traditional laboratory course. This project proposes expand a sustainable CURE project that overcomes both obstacles. Specifically, it plans to grow the Fly-CURE from seven universities to twenty, creating a sustainable Fly-CURE Consortium of institutions that all implement a common undergraduate genetics laboratory component involving mapping and characterization of novel Drosophila melanogaster mutants identified in a genetic screen. Expansion of the Fly-CURE will be accomplished through recruitment and training of new faculty who will implement the research project in their genetics laboratory. The project will measure the impact of the CUREs on student attitudes towards research and gains in common genetics learning objectives, comparing students who participate in Fly-CURE with a comparison group that do not. These findings are anticipated to be widely applicable to undergraduate departments working to provide across-the board research experiences for undergraduate STEM majors. The NSF IUSE: EHR Program supports research and development projects to improve the effectiveness of STEM education for all students. Through the Engaged Student Learning track, the program supports the creation, exploration, and implementation of promising practices and tools.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该项目旨在通过增加本科生参与真正的STEM研究来服务于国家利益。众所周知，研究经历可以提高学生在STEM课程和专业中的表现和保留率。然而，研究机会可能是有限的，而且不公平。因此，许多机构正在开发基于课程的本科生研究经验（CUREs），其中课程的所有学生都参与研究项目。该提案旨在建立一个全国性的本科实验课程联盟，以实现基于果蝇基因突变分析的CURE。这个名为Fly-CURE的项目允许学生通过绘制果蝇基因组中突变的位置并研究突变的解剖学和行为学影响，来从事真实的、基于探究的研究。Fly-CURE目前在七个机构开展活动。该项目打算将Fly-CURE扩大到包括20个机构的网络。扩大计划的目标是社区学院等机构，这些机构为学生提供研究经验的能力有限。该项目打算为教师举办年度研讨会，并将有经验的Fly-CURE教师与新手教师配对，以支持和指导新教师在校园建立Fly-CURE。随着Fly-CURE的扩展，项目团队计划收集有关参加Fly-CURE如何影响学生表现的信息，并将这种表现与没有参加CUREs的传统遗传学课程的学生进行比较。CUREs将传统的本科实验课程转变为本科生可以参与真正的研究项目的场所。为本科生提供真实的研究经验已被证明对学生的知识和对研究的态度产生持久的影响，并可以积极影响来自代表性不足群体的学生攻读STEM学位的人数。两大障碍阻碍着更广泛地实施CURE。首先是创建一个可持续的研究项目，可以由本科生在教室实验室环境中完成；其次是开发一个CURE项目，让学生接触到与传统实验室课程相似的学习目标。本项目建议扩大一个可持续的CURE项目，克服这两个障碍。具体来说，它计划将Fly-CURE从7所大学增加到20所，创建一个可持续的Fly-CURE机构联盟，所有机构都实施一个共同的本科遗传学实验室组件，包括在基因筛选中发现的新型黑胃果蝇突变体的绘制和表征。Fly-CURE的扩展将通过招募和培训新教员来完成，这些教员将在他们的遗传学实验室实施研究项目。该项目将通过比较参加Fly-CURE的学生和不参加Fly-CURE的学生，来衡量CUREs对学生对研究态度的影响，以及在普通遗传学学习目标方面的收获。预计这些发现将广泛适用于致力于为本科STEM专业提供全面研究经验的本科院系。NSF IUSE: EHR计划支持研究和开发项目，以提高所有学生STEM教育的有效性。通过参与学生学习轨道，该计划支持有前途的实践和工具的创建，探索和实施。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Genetic mapping of the p47 (L.3.2) mutation in Drosophilamelanogaster.

• DOI: 10.17912/micropub.biology.000783
• 发表时间: 2023
• 期刊: microPublication biology
• 作者: Cordes, Chloe N;Gouge, Melissa M;Morgan, Hannah;Porter, Carah;Siders, Jamie;Bacab, Erica;Barin, Briana;Becerra, Ixel A;Castillo, Jose;Church, Jared;Condo-Hicks, Shaunacee;Conroy, Kattleya J;Curbelo-Navarro, Isbel;DePrest, Benjamin J;Eady, Adrienne;Edmead, TyMahni;Farouk, Verena;Flores-Torres, Angelica;Girmai, Michael;Gutierrez Navarro, Cynthia I;Guzman, Stan;Harris, Alexis B;Healy, Karin;Jaafar, Alina;Khadr, Abraham;Kiboi, Melissa N;Korte, Stephanie N;Lopez, Celia;Mahdi, Hyder;Mendoza Avalos, Jennifer;Miranda, Kathy;Patel, Dipti;Lopez, Celia;Mahdi, Hyder;Mendoza Avalos, Jennifer;Miranda, Kathy;Patel, Dipti;Patel, Rishi;Pechulis, Sydney;Plachta, Victoria;Rhodes, Kamryn;Sandoval, Andrea M;Thomas, Caila;Valadez-Mendoza, Joselyn A;Vora, Hannah;Yousif, Jonathan;Bieser, Kayla L;Kagey, Jacob D
• 通讯作者: Kagey, Jacob D

clifford (B.4.1) , an allele of CG1603 , causes tissue overgrowth in the Drosophila melanogaster eye.

• DOI: 10.17912/micropub.biology.000936
• 发表时间: 2023
• 期刊: microPublication biology
• 作者: Nowaskie, Reagan R;Kitch, Ashley;Adams, Abby;Anandaraj, Abinaya;Apawan, Ethan;Banuelos, Liliana;Betz, Cassandra J;Bogunia, Julia M;Buechlein, Nicholas;Burns, Morgan R;Collier, Hayley A;Collins, Zach;Combs, Kynzie;Dakarian, Vana D;Daniel, Abigail;De Jesus Iii, Conrad M;Erickson, John D;Estrada, Bianca;Estrada, Kevin;Fields, Sydney;Gabriel, Maya;Garcia, Rosario M;Gitamo, Sylvia;Granath, Emma;Hardin, Sabrina N;Hattling, Emily;Henriquez, Alexandra Vl;Hernandez, Destiny;Johnson, Luke;Kim, Annie H;Kolley, Lillian K;Larue, Katelynn M;Lockwood, Erin;Longoria, Nelia;Lopez, Cassandra;Lopez-Roca Fernandez, Rosario C;Lozano, Sofia;Manthie, Carissa;May, Trinity;Mehrzad, Zorah;Mendoza, Itzel;Mohan, Somya;Mounthachak, Claylan;Muyizere, Merveille;Myers, Margaret R;Newton, Jayce;Nwawueze, Amarachi;Paredes, Ariana J;Pezdek, Marissa N;Phat Nguyen, Hoang;Pobuda, Nadia;Sadat, Sahar;Sailor, Johnathon J;Santiago, David;Sbarbaro, Madison;Schultz Iii, David E;Senobari, Anahita N;Shouse, Emma M;Snarski, Sarah M;Solano, Estefanie;Solis Campos, Naomi;Stewart, Elnora;Szczepaniak, Jessica;Tejeda, Michael;Teoli, Dominic F;Tran, Michael;Trivedi, Nishita;Uribe Aristizabal, Laurita;Vargas, Bryan Z;Walker Iii, Kenneth W;Wasiqi, Joseph;Wong, Joyi;Zachrel, Adira;Shah, Hemin P;Small, Elizabeth;Watts, Charlie T;Croonquist, Paula;Devergne, Olivier;Jones, Amy K;Taylor, Elizabeth E;Kagey, Jacob D;Merkle, Julie A
• 通讯作者: Merkle, Julie A

The I.3.2 developmental mutant has a single nucleotide deletion in the gene centromere identifier.

• DOI: 10.17912/micropub.biology.000653
• 发表时间: 2022
• 期刊: microPublication biology
• 作者: Evans, Cory J;Bieser, Kayla L;Acevedo-Vasquez, Katherine S;Augustine, Emyli J;Bowen, Skyler;Casarez, Veronica A;Feliciano, Vanessa I;Glazier, Ashley;Guinan, Haley R;Hallman, Randy;Haugan, Elizabeth;Hehr, Lauren A;Hunnicutt, Shawna N;Leifer, Isabella;Mauger, Meaghan;Mauger, Morgan;Melendez, Norma Y;Milshteyn, Larry;Moore, Eric;Nguyen, Sarah A;Phanphouvong, Sierra C;Pinal, David M;Pope, Hailee M;Salinas, Mark-Brandon M;Shellin, Matthew;Small, Ivana;Yeoh, Neelufar C;Yokomizo, Alexandra M K;Kagey, Jacob D
• 通讯作者: Kagey, Jacob D

B.2.16 is a non-lethal modifier of the Dark(82) mosaic eye phenotype in Drosophila melanogaster.

• DOI: 10.17912/micropub.biology.000359
• 发表时间: 2021-01-18
• 期刊: microPublication biology
• 作者: Vrailas-Mortimer AD;Aggarwal N;Ahmed NN;Alberts IM;Alhawasli M;Aljerdi IA;Allen BM;Alnajar AM;Anderson MA;Armstong R;Avery CC;Avila EJ;Baker TN;Basardeh S;Bates NA;Beidas FN;Bosler AC;Brewer DM;Buenaventura RS;Burrell NJ;Cabrera-Lopez AP;Cervantes-Gonzalez AB;Cezar RP;Coronel J;Croslyn C;Damery KR;Diaz-Alavez L;Dixit NP;Duarte DL;Emke AR;English K;Eshun AA;Esterly SR;Estrada AJ;Feng M;Freund MM;Garcia N;Ghotra CS;Ghyasi H;Hale CS;Hulsman L;Jamerson L;Jones AK;Kuczynski M;Lacey-Kennedy TN;Lee MJ;Mahjoub T;Mersinger MC;Muckerheide AD;Myers DW;Nielsen K;Nosowicz PJ;Nunez JA;Ortiz AC;Patel TT;Perry NN;Poser WSA;Puga DM;Quam C;Quintana-Lopez P;Rennerfeldt P;Reyes NM;Rines IG;Roberts C;Robinson DB;Rossa KM;Ruhlmann GJ;Schmidt J;Sherwood JR;Shonoda DH;Soellner H;Torrez JC;Velide M;Weinzapfel Z;Ward AC;Bieser KL;Merkle JA;Stamm JC;Tillett RL;Kagey JD
• 通讯作者: Kagey JD

Genetic mapping and phenotypic analysis of shot(H.3.2) in Drosophila melanogaster.

• DOI: 10.17912/micropub.biology.000418
• 发表时间: 2021
• 期刊: microPublication biology
• 作者: Talley EM;Watts CT;Aboyer S;Adamson MG;Akoto HA;Altemus H;Avella PJ;Bailey R;Bell ER;Bell KL;Breneman K;Burkhart JS;Chanley LJ;Cook SS;DesLaurier MT;Dorsey TR;Doyle CJ;Egloff ME;Fasawe AS;Garcia KK;Graves NP;Gray TK;Gustafson EM;Hall MJ;Hayes JD;Holic LJ;Jarvis BA;Klos PS;Kritzmire S;Kuzovko L;Lainez E;McCoy S;Mierendorf JC;Neri NA;Neville CR;Osborn K;Parker K;Parks ME;Peck K;Pitt R;Platta ME;Powell B;Rodriguez K;Ruiz C;Schaefer MN;Shields AB;Smiley JB;Stauffer B;Straub D;Sweeney JL;Termine KM;Thomas B;Toth SD;Veile TR;Walker KS;Webster PN;Woodard BJ;Yoder QL;Young MK;Zeedyk ML;Ziegler LN;Bieser KL;Puthoff DP;Stamm J;Vrailas-Mortimer AD;Kagey JD;Merkle JA
• 通讯作者: Merkle JA