BII-Implementation: GEMS: Genomics and eco-evolution of multi-scale symbioses

BII-实施：GEMS：多尺度共生的基因组学和生态进化

• 批准号: 2022049
• 负责人: Katy Heath
• 金额: $ 1250万
• 依托单位: University of Illinois at Urbana-Champaign
• 依托单位国家: 美国
• 项目类别: Cooperative Agreement
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2022049&HistoricalAwards=false
• 关键词: BII; Implementation; GEMS; Genomics; eco

Humans, and the animals and plants around them, live in a microbial world. It is now well-known that microbes and viruses infect, interact and move through the genomes of every organism on Earth. Relationships among organisms, and with their microbes, can dramatically change the traits, behaviors, and functions of the host plant or animal. Sometimes these interactions are beneficial and sometimes they can be detrimental by causing disease. Many influence host function and can have hidden but important global scale impacts, driving the rates of responses to climate change, health and disease, antibiotic resistance, and more. Understanding how nested interactions within the microbial world occur and influence our ecosystems is critical to controlling their impact. The new Biology Integration Institute, Genomics and Eco-evolution of Multi-Scale Symbiosis (GEMS), focuses on the classical species interaction between clover and honeybee pollinators as a model to understand the impact and dynamics of the myriad of microbes nested within them. The project takes an integrative approach to understand how molecular interactions impact the ecosystem. As a $20 billion US industry, the outcomes of the project studying clover/honeybee nested genomes has practical value as well as being a model for addressing fundamental questions in integrative biology. The researchers in GEMS are collaborative, diverse, interactive scientists and educators who take an inter-disciplinary approach to answer critical questions about how nested genomes interact and affect the world. The project uses a shared leadership model with co-mentorship between trainer and trainee and multisite educational activities. The established institute is designed to integrate biological disciplines to understand how nested genomes respond to environmental change.GEMS will address the fundamental biological question, How do symbioses unify biology, from molecule to ecosystem? The goal of this project is to establish a framework for how the phenotypic variation generated by the mobility of nested symbionts influences the adaptability of traits and the strength and stability of species interactions. Ultimately, the Institute aims to understand how this variation impacts ecosystem responses to environmental change. The Institute is grounded in the canonical symbiosis between flowering plants and insect pollinators (clover and honeybees), expanding to include interactions nested in their microbial world. The research leverages the extensive knowledge in multiple nested interactions (plant–pollinator, legume–rhizobium, honey bee–microbiome) to build connections within and across systems from the molecular processes that govern establishment of symbiosis and extend phenotypic traits to define how they interact and evolve together in the natural world. Data are integrated with ecological and evolutionary theory to generalize beyond the focal systems to build predictive models. Computer science, statistics, and mathematics expand both the range of biological questions asked and the impact of their answers. Along with the traditional academic silos dividing researchers into molecular and organismal units that prevent a unified view of biology are many others, such as those separating microbe from macrobe, plant from animal, student from faculty, education from research, and diversity, equity, and inclusion from science. Through K-12 education in Spanish and targeting excellence with Project Microbe and the Jim Holland program in three urban and rural communities in the Midwest, GEMS focuses on the intersecting goals of changing how biology is done and who does it, unifying biology by including the small but powerful so often overlooked.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

人类和他们周围的动植物生活在微生物世界里。现在众所周知，微生物和病毒感染、相互作用并在地球上每一个有机体的基因组中传播。生物体之间以及它们与微生物之间的关系可以极大地改变宿主植物或动物的特征、行为和功能。这些相互作用有时是有益的，有时可能是有害的，因为它们会导致疾病。许多因素影响宿主功能，并可能产生隐藏但重要的全球范围影响，推动对气候变化、健康和疾病、抗生素耐药性等的反应速度。了解微生物世界中嵌套的相互作用如何发生并影响我们的生态系统，对于控制它们的影响至关重要。新的生物集成研究所，基因组和多尺度共生的生态进化(GEMS)，专注于三叶草和蜜蜂传粉者之间的经典物种相互作用作为模型，以了解嵌套在其中的无数微生物的影响和动态。该项目采取了一种综合的方法来了解分子相互作用如何影响生态系统。作为一个价值200亿美元的美国产业，该项目研究三叶草/蜜蜂嵌套基因组的成果具有实用价值，也是解决综合生物学基本问题的典范。GEMS的研究人员是协作、多样化、互动的科学家和教育工作者，他们采取跨学科的方法来回答关于嵌套基因组如何相互作用和影响世界的关键问题。该项目采用共同领导模式，由培训者和受训者共同指导，并开展多地点教育活动。建立该研究所的目的是整合生物学学科，以了解嵌套基因组如何应对环境变化。GEMS将解决基本的生物学问题，共生如何将生物学从分子统一到生态系统？这个项目的目标是建立一个框架，研究嵌套共生体的迁移性所产生的表型变异如何影响性状的适应性以及物种相互作用的强度和稳定性。最终，该研究所的目标是了解这种变化如何影响生态系统对环境变化的反应。该研究所以开花植物和昆虫传粉者(三叶草和蜜蜂)之间的典型共生为基础，扩大到包括嵌套在它们的微生物世界中的相互作用。这项研究利用多种嵌套相互作用(植物-传粉者、豆类-根瘤菌、蜜蜂-微生物组)中的广泛知识，从管理共生建立的分子过程中建立系统内部和系统之间的联系，并扩展表型特征，以定义它们如何在自然界中相互作用和共同进化。数据与生态和进化理论相结合，以超越焦点系统进行推广，以建立预测模型。计算机科学、统计学和数学既扩大了生物问题的范围，也扩大了它们的答案的影响。除了将研究人员划分为分子和组织单元的传统学术竖井，阻碍了对生物学的统一看法，还有许多其他因素，如将微生物与大型微生物、植物与动物、学生与教职员工、教育与研究、多样性、公平性和包容性与科学分开。通过西班牙语的K-12教育和在中西部的三个城市和农村社区的微生物项目和Jim Holland项目的卓越目标，GEMS专注于改变生物学如何完成以及谁做了它的交叉目标，通过包括经常被忽视的小但强大的东西来统一生物学。这个奖项反映了NSF的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Contemporary evolution rivals the effects of rhizobium presence on community and ecosystem properties in experimental mesocosms

当代进化与实验中生态系统中根瘤菌的存在对群落和生态系统特性的影响相媲美

• DOI: 10.1007/s00442-022-05253-1
• 发表时间: 2022
• 期刊: Oecologia
• 影响因子: 2.7
• 作者: Lau, Jennifer A.;Hammond, Mark D.;Schmidt, Jennifer E.;Weese, Dylan J.;Yang, Wendy H.;Heath, Katy D.
• 通讯作者: Heath, Katy D.

Scaling up and down: movement ecology for microorganisms

放大和缩小：微生物的运动生态学

• DOI: 10.1016/j.tim.2022.09.016
• 发表时间: 2022
• 期刊: Trends in Microbiology
• 影响因子: 15.9
• 作者: Wisnoski, Nathan I.;Lennon, Jay T.
• 通讯作者: Lennon, Jay T.

Traits of soil bacteria predict plant responses to soil moisture

土壤细菌的特征预测植物对土壤湿度的反应

• DOI: 10.1002/ecy.3893
• 发表时间: 2022
• 期刊: Ecology
• 影响因子: 4.8
• 作者: Bolin, Lana G.;Lennon, Jay T.;Lau, Jennifer A.
• 通讯作者: Lau, Jennifer A.

Honey bee symbiont buffers larvae against nutritional stress and supplements lysine

• DOI: 10.1038/s41396-022-01268-x
• 发表时间: 2022-06
• 期刊: The ISME Journal
• 作者: Audrey J. Parish;D. W. Rice;Vicki M. Tanquary;Jason M. Tennessen;I. G. Newton

Optimal dormancy strategies in fluctuating environments given delays in phenotypic switching

考虑到表型转换延迟的波动环境中的最佳休眠策略

• 发表时间: 2023
• 期刊: Journal of theoretical biology
• 影响因子: 2
• 作者: Magalie A, Schwartz DA