Neural dynamics underlying working memory maintenance

工作记忆维护的神经动力学

• 批准号: 2022572
• 负责人: Sarah Shomstein
• 金额: $ 72.33万
• 依托单位: George Washington University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2022572&HistoricalAwards=false
• 关键词: Neural; dynamics; underlying; working; memory

Working memory, the ability to maintain information in mind even when that information is no longer perceptually available, is a fundamental cognitive ability. The mechanism allows us to efficiently apply prior knowledge to the processing of the current context; enabling complex decision-making and guiding attention towards the most relevant features of the environment. While the link between visual working memory (VWM) and attention is well studied, its direct relation to perceptual processing is relatively less clear. This project will leverage the known properties of the neural substrate that supports VWM, to investigate the interaction between what is held in mind and how the mind interprets visual stimuli. The project will identify the time course of this interaction, to understand how content maintained in VWM decays over time. Neural stimulation will then characterize the causal contribution, of cortical areas which support perception, to the maintenance of information in working memory. A better understanding of the mechanisms underlying VWM can inform the design of interactive displays (car dashboards and air traffic controls, for example), and can improve training for numerous professions (such as airport baggage screeners and radiologists).Recent neurophysiological findings, showing that VWM recruits sensorimotor cortical areas, afford a unique opportunity to generate behavioral predictions about this complex and critical cognitive process. This proposal leverages the known neurophysiological properties of sensorimotor areas (such as tuning curves and retinotopy) to generate behavioral predictions about VWM maintenance. First, if the same circuits are utilized by VWM and perception, then each process should interfere with the other. Further, the strength of these effects should scale with the similarity between the maintained and current stimulus, dependent on known visual tuning properties (such as orientation, motion direction, and face spaces). Second, maintained information should decay over time, having less of an effect on perception and becoming more prone to interference, which challenges some models of VWM. Third, initiation and maintenance of VWM depends on dynamics between prefrontal and perceptual cortices. Transcranial magnetic stimulation will be used to investigate the causal interaction between prefrontal and perceptual areas. The proposed research will provide novel, causal, and fundamental insights into how the brain enables and constrains VWM.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

工作记忆是一种基本的认知能力，它是一种即使在信息不再可感知时也能将信息保持在头脑中的能力。该机制使我们能够有效地将先验知识应用于当前上下文的处理;实现复杂的决策并将注意力引导到环境的最相关特征。虽然视觉工作记忆（VWM）和注意力之间的联系已经得到了很好的研究，但它与知觉加工的直接关系相对不太清楚。该项目将利用支持VWM的神经基质的已知特性，研究头脑中所持有的内容与头脑如何解释视觉刺激之间的相互作用。该项目将确定这种相互作用的时间过程，以了解VWM中维护的内容如何随着时间的推移而衰减。然后，神经刺激将表征支持感知的皮层区域对维持工作记忆中的信息的因果贡献。更好地理解VWM的机制可以为交互式显示器的设计（例如汽车仪表板和空中交通管制）提供信息，并可以改善许多专业人员的培训（例如机场行李检查员和放射科医生）最近的神经生理学研究结果表明，VWM招募感觉运动皮层区域，为产生关于这一复杂而关键的认知过程的行为预测提供了独特的机会。该建议利用已知的感觉运动区的神经生理学特性（如调谐曲线和视网膜反射）来产生关于VWM维持的行为预测。首先，如果VWM和感知使用相同的回路，那么每个过程都应该相互干扰。此外，这些效果的强度应该与维持的刺激和当前刺激之间的相似性成比例，这取决于已知的视觉调谐特性（例如取向、运动方向和面部空间）。其次，保持的信息应该随着时间的推移而衰减，对感知的影响较小，并且更容易受到干扰，这对VWM的一些模型提出了挑战。第三，VWM的启动和维持依赖于前额叶皮层和知觉皮层之间的动力学。经颅磁刺激将被用来调查前额叶和知觉区之间的因果关系。拟议中的研究将提供新的，因果关系，以及对大脑如何启用和约束VWM的基本见解。该奖项反映了NSF的法定使命，并已被认为是值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估的支持。

项目成果

How much is a cow like a meow? A novel database of human judgements of audiovisual semantic relatedness

一头牛有多像喵？

• DOI: 10.3758/s13414-022-02488-1
• 发表时间: 2022
• 期刊: & Psychophysics
• 作者: Wegner-Clemens, Kira;Malcolm, George L.;Shomstein, Sarah
• 通讯作者: Shomstein, Sarah

Attention and platypuses

• DOI: 10.1002/wcs.1600
• 发表时间: 2022-04-20
• 期刊: WILEY INTERDISCIPLINARY REVIEWS-COGNITIVE SCIENCE
• 影响因子: 3.9
• 作者: Shomstein，Sarah;Zhang，Xiaoli;Dubbelde，Dick
• 通讯作者: Dubbelde，Dick