BAFF-receptor function in B cell survival and immune responses (06)

BAFF受体（BAFF-R）是外周B细胞的关键存活受体。为了结合其配体BAFF，BAFF-R必须多聚化。已发现由BAFF-R中的单个错义突变引起的多聚化减少损害B细胞信号传导和B细胞应答。Project 06发现BAFF-R和相关受体TACI可以在人类记忆B细胞上形成混合寡聚体。在第二个资助期内，将研究在不同人B细胞群中检测到的BAFF-R和TACI与CD 19的相互作用。蛋白酶依赖的BAFF-R加工途径将详细检查。新的敲入小鼠模型将允许表征BAFF-R多聚化的机制细节。

The BAFF-receptor (BAFF-R) is a key survival receptor of peripheral B cells. In order to bind its ligand BAFF, BAFF-R has to multimerize. Decreased multimerization caused by a single missense mutation in BAFF-R has been found to impair B cell signalling and B cell responses. Project 06 has found that BAFF-R and the related receptor TACI can form mixed oligomers on human memory B cells. In the second funding period, the detected interactions of BAFF-R and TACI with CD19 in different human B cell populations will be studied. The protease dependent BAFF-R processing pathway will be examined in detail. New knockin mouse models will allow to characterize the mechanistic details of BAFF-R multimerization.