RAPID: Mixed-Dimensional Heterostructure Materials based SERS for Trace Level Fingerprint Identification of SARS-CoV-2 RNA

RAPID：基于混合维异质结构材料的 SERS，用于 SARS-CoV-2 RNA 痕量水平指纹识别

• 批准号: 2030439
• 负责人: Paresh Ray
• 金额: $ 20万
• 依托单位: Jackson State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-15 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2030439&HistoricalAwards=false
• 关键词: RAPID; Mixed; Dimensional; Heterostructure; Materials

Current novel coronavirus infection (COVID-19) diagnostic tests, used worldwide, take significant time, typically more than a day, to confirm results. There is an urgent need for a rapid coronavirus test platform throughout the world at this moment. This RAPID project will develop sensitive, fast and simple-to-use optical techniques to detect viral-RNA using Raman spectroscopy, which has capability for specific identification of COVID-19. The goal of this project is to design new material-based robust optical platform to detect trace level virus RNA. This will be accomplished by measuring the Raman signal from COVID-19 RNA. The expected outcome is a nanomaterial based technology underlying a portable device for accurate and immediate diagnosis of viral infections from COVID-19. The proposed research will enable approaches that mitigate the negative impacts of COVID-19 on public health, society, and the economy. This Rapid Response Research (RAPID) grant supports research with funding from the Partnerships for Research and Education in Materials (PREM) Program in the Division of Materials Research of the Mathematical and Physical Sciences Directorate, with co-funding from the HBCU-EiR program.Novel material-based technologies for sensitive and rapid identification of COVID-19 is very important to tackle COVID-19 epidemic threat. The current project will contribute towards the development of novel mixed dimensional heterostructure based surface enhanced Raman spectroscopy (SERS) platform for highly efficient and immediate fingerprint identification of SARS-CoV-2 RNA. Specifically, the objectives include development of innovative 2D-0D, 1D-0D, and 2D-1D heterostructure building blocks and creating novel heterostructure-based SERS platform-based technology. The mixed-dimensional heterostructure material will offer opportunities for revolutionary advances in designing SERS platform. The SERS platform will provide accurate identification of the COVID-19 RNA, which can be used in both clinical and field settings. The RAPID program will serve as the bridge among scientific research, technological development, and educational activities for African American students.This grant is being awarded using funds made available by the Coronavirus Aid, Relief, and Economic Security (CARES) Act supplemental funds allocated to MPS.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

当前使用的新型冠状病毒感染（COVID-19）诊断测试在全球范围内使用，需要大量时间（通常超过一天）来确认结果。目前，迫切需要在全球范围内快速的冠状病毒测试平台。这个快速的项目将使用拉曼光谱法开发敏感，快速和易于使用的光学技术来检测病毒-RNA，该光谱具有特定鉴定COVID-19的能力。该项目的目的是设计新的基于材料的强大光学平台来检测痕量水平病毒RNA。这将通过测量来自COVID-19 RNA的拉曼信号来实现。预期的结果是一种基于便携式装置的基于纳米材料的技术，用于准确，立即诊断出来自Covid-19的病毒感染。拟议的研究将使方法能够减轻Covid-19对公共卫生，社会和经济的负面影响。这项快速响应研究（Rapid）Grant通过在数学和物理科学局的材料研究部的研究和材料研究伙伴关系（PERM）计划的资助中支持研究，并从HBCU-EIR计划中获得了基于材料的技术，用于材料基于材料的技术，用于对Covid-19的敏感和快速识别对Covid-19的敏感和快速识别对COVID-19对Covid Covid Covid-19 covid-19 epidepictiveption非常重要。当前的项目将有助于开发基于新型混合尺寸异质结构的表面增强拉曼光谱（SERS）平台，以高效且直接立即对SARS-COV-2 RNA识别。具体而言，这些目标包括开发创新的2D-0D，1D-0D和2D-1D异质结构构建块，以及创建基于异质的新型SERS基于SERS平台的技术。混合尺寸的异质结构材料将为设计SERS平台的革命进步提供机会。 SERS平台将对COVID-19 RNA进行准确的识别，可用于临床和现场设置。快速计划将作为科学研究，技术发展和非裔美国学生的教育活动之间的桥梁。这笔赠款正在使用冠状病毒援助，救济和经济安全和经济安全（CARES）法案提供的补充资金提供的资金授予​​，该资金补充资金为MPS提供了补充资金。该奖项颁发了NSF的法定任务，并通过评估律师的范围来审查律师的范围。

项目成果

Aptamer Conjugated Gold Nanostar-Based Distance-Dependent Nanoparticle Surface Energy Transfer Spectroscopy for Ultrasensitive Detection and Inactivation of Corona Virus

• DOI: 10.1021/acs.jpclett.0c03570
• 发表时间: 2021-02-25
• 期刊: JOURNAL OF PHYSICAL CHEMISTRY LETTERS
• 影响因子: 5.7
• 作者: Pramanik, Avijit;Gao, Ye;Ray, Paresh Chandra
• 通讯作者: Ray, Paresh Chandra