STTR Phase I: Rapid Acting Disinfectant Spray for Slowing the Spread of COVID-19

这个小企业技术转让（STTR）项目的更广泛的影响/商业潜力是开发一种消毒剂喷雾剂，以遏制通过接触受污染表面传播SARS-CoV-2。COVID-19传播主要通过感染者产生的呼吸道飞沫以及接触含有病毒的飞沫的表面发生。通过接触表面来减轻感染是一种措施，可以在开发疫苗或其他保护措施之前减缓新型病毒的传播。结合其他措施，新型消毒剂将在COVID-19大流行期间支持公共卫生。目前的消毒剂需要30秒至10分钟的时间进行消毒，以在应用后开始并且不继续消毒。所提出的技术在应用表面上形成了一种临时的、持续的消毒膜。该STTR第一阶段项目将展示新型喷雾剂的快速性能及其在应用后形成临时和持续消毒膜的能力。该技术采用含有快速响应掺杂纳米氧化铈的选择介质，其中氧化响应/机制被设计为并行执行几个消毒反应。使用工程纳米氧化铈的安全、快速、多消毒剂方法先前尚未被证明可用于使用。该项目还将证明应用后的消毒性能。该项目的目标将通过以下方式实现：1）抗病毒、多机制消毒剂制剂的开发，2）功效和安全性的证明，3）产品稳定性的研究，和4）临时膜形成、稳定性的证明，该奖项反映了NSF的法定使命，并通过使用基金会的智力价值进行评估，更广泛的影响审查标准。

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) project is development of a disinfectant spray to curb the transmission of SARS-CoV-2 via contact with contaminated surfaces. COVID-19 transmission occurs primarily via respiratory droplets produced by an infected person and by contact with a surface where a droplet containing the virus exists. Mitigating infection by contact with surfaces is a measure that will slow the spread of novel viruses ahead of development of a vaccine or other protective measures. In conjunction with other measures, a novel disinfectant will support public health during the COVID-19 pandemic. Current disinfectants require times ranging from 30 seconds to 10 minutes for disinfection to begin after application and do not continue to disinfect. The proposed technology creates a temporary, continually disinfecting film that remains on the application surface. This STTR Phase I project will demonstrate both the rapid performance of a novel spray and its ability to form a temporary and continually disinfecting film post=application. This technology employs a select medium containing fast-response doped nanoceria where the oxidizing response/mechanism is engineered to perform several disinfectant reactions in parallel. A safe, rapid, multi-disinfectant approach using engineered nanoceria has not previously been demonstrated for use. The project will also demonstrate the post-application disinfection properties. The goals of this project will be achieved with the following: 1) development of an anti-viral, multi-mechanism disinfectant formulation, 2) demonstration of efficacy and safety, 3) study of product stability, and 4) demonstration of temporary film formation, stability, and activity.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.