Collaborative Proposal: Developmental and Genetic Pathways to Phenotypic Convergence in a Radiation of Groundwater Salamanders
合作提案:地下水蝾螈辐射表型趋同的发育和遗传途径
基本信息
- 批准号:2032633
- 负责人:
- 金额:$ 36.67万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-01 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Cave organisms as unrelated as insects and salamanders often have shared features – such as lack of eyes, pallid coloration, and elongated limbs. Life underground provides different challenges from life on the surface, and those challenges favor relatively rapid changes in appearance (and other, more subtle characteristics) at the population level. Those rapid changes lead to convergence in the appearance of many cave organisms, but the genetic and developmental processes that lead to repeated changes in different organisms are largely unknown. The Edwards Plateau of central Texas has an extensive, though fragmented, network of springs, caves, and aquifers that host numerous, diverse, underground salamanders. These salamanders attain reproductive maturity while retaining features (such as gills) that are characteristic of immature salamanders, and many of them show eyes reduced in size and development to varying degrees, along with other characteristics associated with living underground (e.g. an enhanced sense of smell). These characteristics have evolved independently and repeatedly in the various species, and this research will integrate information derived through a variety of approaches to shed light on the mechanisms that enable new structures and functions to evolve. This project is timely because in addition to enhancing understanding of the evolution of sensory systems, it will highlight and clarify the diversity of salamanders in central Texas at a time when human population growth and commercial development further threaten species that have been identified as being in danger of extinction. Finally, this project will serve as a platform to train numerous undergraduates in STEM research.The researchers will use an integrative, hierarchical approach combining genetic, developmental, and phylogenetic perspectives to study the mechanisms that drive convergence in phenotypes of subterranean Groundwater Salamanders. Results from micro-computed tomography imaging, histology, transcriptomics, and exon sequencing will demonstrate the degree of morphological convergence in sensory systems (visual, olfactory, and lateral line) across subterranean lineages. Comparative transcriptomics will be employed to examine the developmental genetic mechanisms of organ system reduction and signatures of molecular convergence at the protein-coding level in sensory-system genes.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
像昆虫和火蜥蜴这样互不相关的洞穴生物通常都有共同的特征--比如没有眼睛,脸色苍白,四肢伸长。地下生活带来了与地表生活不同的挑战,而这些挑战有利于种群水平上相对快速的外表变化(以及其他更微妙的特征)。这些快速的变化导致许多洞穴生物的外观趋同,但导致不同生物重复变化的遗传和发育过程在很大程度上是未知的。得克萨斯州中部的爱德华兹高原有一个广泛的、尽管支离破碎的泉水、洞穴和含水层网络,其中居住着无数不同的地下火蜥蜴。这些火蜥蜴达到生殖成熟的同时,保留了未成熟火蜥蜴特有的特征(如鳃),其中许多显示出眼睛不同程度地缩小和发育,以及与生活在地下有关的其他特征(如嗅觉增强)。这些特征在不同物种中独立和重复地进化,这项研究将整合通过各种方法获得的信息,以阐明使新结构和功能得以进化的机制。这个项目是及时的,因为除了加强对感官系统进化的了解外,它还将突出和澄清德克萨斯州中部火蜥蜴的多样性,而此时人类人口增长和商业发展进一步威胁到已被确定为濒临灭绝的物种。最后,这个项目将作为一个平台,培训众多的本科生进行STEM研究。研究人员将使用综合的、分层次的方法,结合遗传、发育和系统发育的观点来研究驱动地下地下水火蜥蜴表型趋同的机制。来自微型计算机断层成像、组织学、转录学和外显子测序的结果将显示跨越地下谱系的感觉系统(视觉、嗅觉和侧线)的形态融合程度。比较转录组学将被用来在感觉系统基因的蛋白质编码水平上研究器官系统减少的发育遗传学机制和分子趋同的特征。这一奖项反映了NSF的法定使命,并通过使用基金会的智力优势和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Dana García其他文献
Phenotypic and genotypic study of antibiotic-resistant Escherichia coli isolates from a wastewater treatment plant in Zulia state, Venezuela.
委内瑞拉苏利亚州废水处理厂分离出的耐抗生素大肠杆菌的表型和基因型研究。
- DOI:
10.54817/ic.v64n3a03 - 发表时间:
2023 - 期刊:
- 影响因子:0
- 作者:
Elba Guerrero;Lizeth Caraballo;Howard Takiff;Dana García;Marynes Montiel - 通讯作者:
Marynes Montiel
Ammonia concentration at emergence and its effects on the recovery of different species of entomopathogenic nematodes.
出苗时氨浓度及其对不同种类昆虫病原线虫恢复的影响。
- DOI:
- 发表时间:
2014 - 期刊:
- 影响因子:2.1
- 作者:
E. San‐Blas;D. Pirela;Dana García;Edgar Portillo - 通讯作者:
Edgar Portillo
Dana García的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Dana García', 18)}}的其他基金
FISH and Chips: Applying Microarray Technology and in Situ Hybridization to Understanding Light-Adaptation in Zebrafish
FISH 和芯片:应用微阵列技术和原位杂交来了解斑马鱼的光适应
- 批准号:
0615762 - 财政年份:2006
- 资助金额:
$ 36.67万 - 项目类别:
Standard Grant
RUI: Pigment Granule Dispersion in Teleost Retinal Pigment Epithelium: Cholinergic Mechanisms
RUI:硬骨鱼视网膜色素上皮中的色素颗粒分散:胆碱能机制
- 批准号:
0235523 - 财政年份:2003
- 资助金额:
$ 36.67万 - 项目类别:
Standard Grant
RUI: Pigment Granule Dispersion in Teleost Retinal Pigment Epithelium: Cholinergic Mechanisms
RUI:硬骨鱼视网膜色素上皮中的色素颗粒分散:胆碱能机制
- 批准号:
0077666 - 财政年份:2000
- 资助金额:
$ 36.67万 - 项目类别:
Standard Grant
U.S.-Germany Cooperative Research: Intermediate Filament Function in Teleost Retinal Pigment Epithelium
美德合作研究:硬骨鱼视网膜色素上皮的中间丝功能
- 批准号:
0078261 - 财政年份:2000
- 资助金额:
$ 36.67万 - 项目类别:
Standard Grant
Minority Research Initiation Planning Grant
少数族裔研究启动规划补助金
- 批准号:
9411836 - 财政年份:1994
- 资助金额:
$ 36.67万 - 项目类别:
Standard Grant
相似海外基金
Collaborative Proposal: Developmental and Genetic Pathways to Phenotypic Convergence in a Radiation of Groundwater Salamanders
合作提案:地下水蝾螈辐射表型趋同的发育和遗传途径
- 批准号:
2032632 - 财政年份:2020
- 资助金额:
$ 36.67万 - 项目类别:
Standard Grant
Collaborative Proposal: Developmental Mechanisms of African American Ethnic and Racial Identity During the Transition to Adulthood
合作提案:向成年过渡期间非裔美国人民族和种族身份的发展机制
- 批准号:
2027610 - 财政年份:2019
- 资助金额:
$ 36.67万 - 项目类别:
Standard Grant
Collaborative Proposal: Developmental mechanisms of African American Ethnic and Racial Identity during the transition to adulthood.
合作提案:向成年过渡期间非裔美国人民族和种族身份的发展机制。
- 批准号:
1823965 - 财政年份:2018
- 资助金额:
$ 36.67万 - 项目类别:
Standard Grant
Collaborative Proposal: Developmental Mechanisms of African American Ethnic and Racial Identity During the Transition to Adulthood
合作提案:向成年过渡期间非裔美国人民族和种族身份的发展机制
- 批准号:
1823963 - 财政年份:2018
- 资助金额:
$ 36.67万 - 项目类别:
Standard Grant
A proposal of cognitive model related to fluency in children with developmental dyslexia
发展性阅读障碍儿童流畅性相关认知模型的提出
- 批准号:
16K17463 - 财政年份:2016
- 资助金额:
$ 36.67万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Elucidation of the developmental mechanisms, proposal of a new classification and the establishment of novel diagnostic and treatment methods for neuroendocrine breast carcinoma
阐明神经内分泌乳腺癌的发生机制、提出新的分类并建立新的诊断和治疗方法
- 批准号:
25460414 - 财政年份:2013
- 资助金额:
$ 36.67万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Pathological analyses of developmental mechanisms and proposal fora new breast neuroendocrine tumor (B-NET) classification
发育机制的病理分析和新乳腺神经内分泌肿瘤(B-NET)分类的建议
- 批准号:
23790394 - 财政年份:2011
- 资助金额:
$ 36.67万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Audition and Autism A proposal for creating a CIHR team to enhance research and partnerships combating developmental communication disorders
试镜和自闭症 建立 CIHR 团队的提案,以加强对抗发展性沟通障碍的研究和伙伴关系
- 批准号:
185641 - 财政年份:2009
- 资助金额:
$ 36.67万 - 项目类别:
Operating Grants
Collaborative Research Proposal: Tipping the Scales - A selection approach to the developmental regulation of morphological scaling
合作研究提案:倾斜尺度——形态尺度发育调节的选择方法
- 批准号:
0920720 - 财政年份:2009
- 资助金额:
$ 36.67万 - 项目类别:
Standard Grant
Experimental study on the significance of developmental growth through interactions with nature -proposal of a practical model for child care
通过与自然互动促进发育成长的意义的实验研究——提出实用的儿童保育模型
- 批准号:
21500888 - 财政年份:2009
- 资助金额:
$ 36.67万 - 项目类别:
Grant-in-Aid for Scientific Research (C)