Pathological analyses of developmental mechanisms and proposal fora new breast neuroendocrine tumor (B-NET) classification

我们首先描述了一些乳腺神经内分泌肿瘤(B-Net)的背景组织中广泛分布的外观正常的神经内分泌(NE)细胞，表现为孤立/散在、簇状和/或环状突起的模式，其中包括N教育原位癌(NE-DCIS)。这些新的发现可以被认为是与B-net发展相关的“NE细胞增生”，是一种癌前病变。此外，我们还发现低度恶性B-net与导管内乳头状瘤密切相关，而高度恶性B-net则与传统的导管原位癌密切相关。因此，我们发现B-net的发生涉及多种机制。

We first described widely distributed normal-lookingneuroendocrine (NE) cells showing isolated/scattered, clustered and/or circumferentialemerging patterns in background tissues of some breast NE tumors (B-NET) including NEductal carcinoma in situ (NE-DCIS). These novel findings could be regarded asrepresenting “NE cell hyperplasia” relevant to B-NET development as a precancerouslesion. In addition, we reported low-grade B-NET closely associated with intraductalpapilloma and high-grade B-NET containing conventional in situ ductal carcinoma foci.Thus, we have shown that multiple mechanisms are involved in the development of B-NET.