Pathological analyses of developmental mechanisms and proposal fora new breast neuroendocrine tumor (B-NET) classification

我们首先描述了广泛分布的看起来正常的神经内分泌（NE）细胞，在一些乳腺NE肿瘤（B-NET）的背景组织中显示孤立/分散、聚集和/或环状新出现的模式，包括导管原位癌（NE- dcis）。这些新发现可能被认为代表了与B-NET发展相关的“NE细胞增生”作为癌前病变。此外，我们报道了与导管内乳头状瘤密切相关的低级别B-NET和含有常规原位导管癌灶的高级别B-NET。因此，我们已经证明了多种机制参与了B-NET的开发。

We first described widely distributed normal-lookingneuroendocrine (NE) cells showing isolated/scattered, clustered and/or circumferentialemerging patterns in background tissues of some breast NE tumors (B-NET) including NEductal carcinoma in situ (NE-DCIS). These novel findings could be regarded asrepresenting “NE cell hyperplasia” relevant to B-NET development as a precancerouslesion. In addition, we reported low-grade B-NET closely associated with intraductalpapilloma and high-grade B-NET containing conventional in situ ductal carcinoma foci.Thus, we have shown that multiple mechanisms are involved in the development of B-NET.