Pathological analyses of developmental mechanisms and proposal fora new breast neuroendocrine tumor (B-NET) classification

我们首先描述了在一些乳腺NE肿瘤（B-NET）包括NE原位癌（NE-DCIS）的背景组织中广泛分布的正常外观的神经内分泌（NE）细胞，这些细胞表现为孤立/散在、成簇和/或周向出现的模式。这些新的发现可被认为是代表与B-NET发展相关的“NE细胞增生”作为癌前病变。此外，我们还报道了与导管内乳头状瘤密切相关的低级别B-NET和包含传统原位导管癌灶的高级别B-NET，因此，我们表明B-NET的发生涉及多种机制。

We first described widely distributed normal-lookingneuroendocrine (NE) cells showing isolated/scattered, clustered and/or circumferentialemerging patterns in background tissues of some breast NE tumors (B-NET) including NEductal carcinoma in situ (NE-DCIS). These novel findings could be regarded asrepresenting “NE cell hyperplasia” relevant to B-NET development as a precancerouslesion. In addition, we reported low-grade B-NET closely associated with intraductalpapilloma and high-grade B-NET containing conventional in situ ductal carcinoma foci.Thus, we have shown that multiple mechanisms are involved in the development of B-NET.