Nanoparticle Interactions and Nanoscale Transport in Polyelectrolyte Brushes

聚电解质刷中的纳米粒子相互作用和纳米级传输

• 批准号: 2034122
• 负责人: Karen Winey
• 金额: $ 52万
• 依托单位: University of Pennsylvania
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2034122&HistoricalAwards=false
• 关键词: Nanoparticle; Interactions; Nanoscale; Transport; Polyelectrolyte

Nanoparticles come in a variety of sizes, shapes, chemistries, and functionalities, including folded proteins, viruses, and quantum dots. This project will research the motion of individual nanoparticles in complex environments. Most previous studies of nanoparticle motion have been limited to studies of ensembles of particles or particles in homogeneous environments, and these studies provide a valuable foundation upon which to build. Recent advances in imaging methods and data processing methods enable the study of nanoparticles in heterogeneous environments one particle at a time. A new imaging method provides improved spatial and temporal resolution that detects biomolecules at interface, and the investigators will apply this advanced imaging method to the study of nanoparticle motion at interfaces, particularly interfaces with various functionalities. These studies and fundamental understanding will inform advanced strategies for separating natural or synthetic nanoparticles based on size, shape, or charge. The investigators will mentor undergraduate researchers, engage with public outreach events across Philadelphia, and partner with a program to bring the science laboratory to underserved high school students.Nanoparticles come in a variety of sizes, shapes, chemistries, and functionalities, ranging from folded proteins, viruses, and quantum dots. Because nanoparticles at interfaces underpin a broad and expanding range of applications including nanoscale filtering and detection, this project will research the motion of individual nanoparticles in complex local environments. Most previous studies of nanoparticle motion have been limited to studies of ensembles of particles or particles in homogeneous environments, and these studies provide a valuable foundation upon which to build. Recent advances in imaging methods and data processing methods enable the study of nanoparticles in heterogeneous environments one particle at a time. Interferometric scattering microscopy provides exceptional spatial and temporal resolution and was originally developed to image biomolecules at interfaces. This project will use this advanced method to study nanoparticle motion at interfaces, particularly interfaces with various functionalities, and under applied electric fields. These studies and fundamental understanding will inform advanced strategies for separating natural or synthetic nanoparticles based on size, shape, or charge by designing interfaces that selectively trap nanoparticles. This new understanding will also provide strategies for producing higher quality nanoparticle products with more uniform characteristics. Differentiating mechanisms of nanoparticle dynamics can also lead to advanced sensing applications. PIs Winey and Composto will mentor undergraduate researchers, engage with public outreach events across Philadelphia, and partner with a program to bring the science laboratory to underserved high school students.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

纳米颗粒有各种尺寸、形状、化学成分和功能，包括折叠蛋白质、病毒和量子点。该项目将研究复杂环境中单个纳米颗粒的运动。 大多数先前对纳米颗粒运动的研究仅限于对均匀环境中的颗粒或颗粒集合的研究，这些研究提供了宝贵的基础。成像方法和数据处理方法的最新进展使得能够一次研究一个粒子在异质环境中的纳米粒子。一种新的成像方法提供了改进的空间和时间分辨率，可以检测界面处的生物分子，研究人员将应用这种先进的成像方法来研究界面处的纳米粒子运动，特别是具有各种功能的界面。这些研究和基本理解将为根据尺寸、形状或电荷分离天然或合成纳米粒子的先进策略提供信息。研究人员将指导本科生研究人员，参与费城各地的公共宣传活动，并与一个项目合作，为服务不足的高中生提供科学实验室。纳米颗粒有各种尺寸、形状、化学成分和功能，包括折叠蛋白质、病毒和量子点。由于界面处的纳米颗粒支撑着广泛且不断扩大的应用范围，包括纳米级过滤和检测，因此该项目将研究单个纳米颗粒在复杂局部环境中的运动。 大多数先前对纳米颗粒运动的研究仅限于对均匀环境中的颗粒或颗粒集合的研究，这些研究提供了宝贵的基础。成像方法和数据处理方法的最新进展使得能够一次研究一个粒子在异质环境中的纳米粒子。干涉散射显微镜提供卓越的空间和时间分辨率，最初是为了对界面处的生物分子进行成像而开发的。该项目将使用这种先进的方法来研究纳米颗粒在界面处的运动，特别是具有各种功能的界面以及在施加电场下的运动。这些研究和基本理解将为通过设计选择性捕获纳米颗粒的界面，根据尺寸、形状或电荷分离天然或合成纳米颗粒的先进策略提供信息。这种新的认识还将提供生产具有更均匀特性的更高质量纳米颗粒产品的策略。纳米颗粒动力学的差异化机制也可以带来先进的传感应用。 PIs Winey 和 Composto 将指导本科生研究人员，参与费城各地的公共宣传活动，并与一个项目合作，为服务不足的高中生提供科学实验室。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Enhancing Nanoparticle Detection in Interferometric Scattering (iSCAT) Microscopy Using a Mask R-CNN

使用掩模 R-CNN 增强干涉散射 (iSCAT) 显微镜中的纳米颗粒检测

• DOI: 10.1021/acs.jpcb.3c00097
• 发表时间: 2023
• 期刊: The Journal of Physical Chemistry B
• 作者: Boyle, Michael J.;Goldman, Yale E.;Composto, Russell J.
• 通讯作者: Composto, Russell J.

ToF-SIMS Depth Profiling to Measure Nanoparticle and Polymer Diffusion in Polymer Melts

ToF-SIMS 深度分析可测量聚合物熔体中的纳米粒子和聚合物扩散

• DOI: 10.1021/acs.macromol.3c00033
• 发表时间: 2023
• 期刊: Macromolecules
• 影响因子: 5.5
• 作者: Wang, Kaitlin;Composto, Russell J.;Winey, Karen I.
• 通讯作者: Winey, Karen I.

Shape Anisotropy Enhances Nanoparticle Dynamics in Nearly Homogeneous Hydrogels

• DOI: 10.1021/acs.macromol.2c01577
• 发表时间: 2022-09
• 期刊: Macromolecules
• 影响因子: 5.5
• 作者: K. A. Rose;Natalie Gogotsi;Jonathan H. Galarraga;J. Burdick;C. Murray;Daeyeon Lee;R. Composto

pH-Mediated Size-Selective Adsorption of Gold Nanoparticles on Diblock Copolymer Brushes

pH 介导的金纳米粒子在二嵌段共聚物刷上的尺寸选择性吸附

• DOI: 10.1021/acsnano.3c00212
• 发表时间: 2023
• 期刊: ACS Nano
• 影响因子: 17.1
• 作者: Kim, Ye Chan;Composto, Russell J.;Winey, Karen I.
• 通讯作者: Winey, Karen I.