STTR Phase I: The Coupling of COVID-19 Respiratory Droplet Adsorption and Photocatalysis through Metal Organic Frameworks

STTR 第一阶段：通过金属有机框架耦合 COVID-19 呼吸道飞沫吸附和光催化

• 批准号: 2036542
• 负责人: OSMAN OZDEMIR
• 金额: $ 24.75万
• 依托单位: framergy, Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-15 至 2022-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2036542&HistoricalAwards=false
• 关键词: STTR; Phase; Coupling; COVID; 19

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase I project is the prevention of the spread of SARS-CoV-2 (COVID-19) through airborne droplet isolation and destruction. Living in a post-pandemic world means that the virus must be mitigated in our surroundings. The proposed technology offers a method for viral removal and inactivation, and it is expected to offer protection against emergent strains and spread of other future viruses. The proposed technology is already being used to improve the energy efficiency of heating, ventilation and air conditioning (HVAC) systems, which have been shown to be a major concentrators of the virus. The chemistry as a coating can be rapidly applied to any negative air pressure devices, such as masks (respirators and surgical), and air purifiers, making cluster indoor locations safer for inhabitants and workers. The proposed technology can inactivate viruses using visible light, offering cost and safety advantages over ultraviolet (UV) inactivation, as UV is not safe for skin exposure. This STTR project will develop a metal-organic framework (MOF)-based respiratory droplet adsorption coating, which, when activated, will photocatalytically destroy COVID-19 and other airborne contaminants. The project proposes to couple the water adsorptive capacity of nanostructured titanium metal organic frameworks with their photocatalytic oxidation capability to destroy COVID-19 in situ to make indoor spaces safer. The project will advance a coordination polymer-based chemistry which can render COVID-19 inactive through microdroplet isolation and photocatalytic decontamination. Based on their highly tunable priorities and catalytic properties, metal-organic frameworks (MOFs) constitute an effective solution to capture COVID-19 micro-droplets and treat them for their viral content. Preliminary test results have showed that that MOFs can photocatalytically render COVID-19 inactive but there are still stability risks to mitigate. The high valence titanium-based MOFs can address the chemical stability challenges of MOFs, which can eliminate the technical hurdles associated with long term stability, cyclic harvesting of micro-air droplets at low relative humidity and their integration into existing heating, ventilation and air conditioning systems.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这项小企业技术转让（STTR）第一阶段项目的更广泛影响/商业潜力是，通过隔离和销毁空气中的飞沫，防止SARS-CoV-2 （COVID-19）的传播。生活在大流行后的世界意味着必须在我们周围减轻病毒。提出的技术提供了一种病毒去除和灭活的方法，并有望提供对突发毒株和其他未来病毒传播的保护。这项提议的技术已经被用于提高供暖、通风和空调（HVAC）系统的能源效率，这些系统已被证明是病毒的主要集中地。作为涂层的化学物质可以迅速应用于任何负压设备，如口罩（呼吸器和外科口罩）和空气净化器，使室内聚集场所对居民和工人更安全。所提出的技术可以使用可见光灭活病毒，与紫外线（UV）灭活相比，具有成本和安全性优势，因为紫外线对皮肤暴露不安全。该str项目将开发一种基于金属有机框架（MOF）的呼吸液滴吸附涂层，该涂层在激活后将光催化破坏COVID-19和其他空气污染物。该项目建议将纳米结构钛金属有机框架的水吸附能力与其光催化氧化能力结合起来，就地消灭COVID-19，使室内空间更安全。该项目将推进一种基于配位聚合物的化学方法，通过微滴分离和光催化去污使COVID-19失活。基于其高度可调的优先级和催化性能，金属有机框架（mof）构成了捕获COVID-19微液滴并对其病毒含量进行处理的有效解决方案。初步测试结果表明，mof可以光催化使COVID-19失活，但仍有稳定性风险需要缓解。高价钛基mof可以解决mof的化学稳定性挑战，它可以消除与长期稳定性相关的技术障碍，在低相对湿度下循环收集微空气液滴，并将其集成到现有的供暖，通风和空调系统中。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

SARS-CoV-2 Inactivation Potential of Metal Organic Framework Induced Photocatalysis

金属有机框架诱导光催化的 SARS-CoV-2 灭活潜力

• DOI: 10.1101/2020.10.01.20204214
• 发表时间: 2020
• 期刊: Medical Archives
• 作者: Ornstein, J;Ozdemir, R;Boehme, A;Nouar, F;Serre, C;Ackerman, D;Herrera, V;Santarpia, J
• 通讯作者: Santarpia, J