Understanding the role of the corepressor protein KAP1 in DNA damage response pathway

DNA损伤反应途径的缺陷是许多人类遗传性疾病和疾病的基础，包括癌症。对这一过程的详细了解对未来的医学有着巨大的意义。我们对参与DNA损伤信号传导的新参与者的表征将有助于筛选可应用于化疗和/或放疗的该途径的抑制剂。该提案将使澳大利亚成为这一具有国际意义和高度竞争力的研究领域的领导者，从而创造新的化合物。掌握这一技术将为澳大利亚创造知识产权收入、新型出口和新企业的机会。

Defects in the DNA damage response pathway underpin many human genetic disorders and diseases, including cancer. A detailed understanding of this process has enormous implications for future medicine. Our characterization of a new player involved in DNA damage signalling will help in screening of inhibitors of this pathway that could be applied in chemo-and/or radiotherapy. The proposal will place Australia among the leaders in this internationally significant and highly competitive area of research leading to the creation of new compounds. Capture of this technology will create the opportunity for IP income, novel exports and new enterprises for Australia.