Functional characterisation of CMAP, a novel centrosome- and midbody-associated protein

细胞分裂是一个高度调控的过程，涉及许多成分，以产生两个含有等量DNA的子细胞。因此，调节这一过程的特定蛋白质的不正确定位和修饰导致细胞分裂错误，从而导致基因组不稳定。我们最近发现了一种叫做CMAP的新蛋白质，它参与了细胞分裂的最后阶段，包括细胞膜的分裂以产生两个子细胞。在这里，我们的目标是表征CMAP功能的机制，并鉴定和表征CMAP结合蛋白，以进一步了解细胞分裂的最后阶段所涉及的机制，以维持基因组的稳定性。

Cell division is a highly regulated process involving many components to produce two daughter cells which contain an equal amount of DNA. Thus incorrect localisation and modification of specific proteins that regulate this process cause cell division errors resulting in genomic instability. We have recently identified a novel protein called CMAP that is involved in the final stages of cell division, which involves the cleavage of the cell membrane to produce two daughter cells. Here, we aim to characterise the mechanism(s) of CMAP function and to identify and characterise CMAP binding proteins to further understand the mechanisms involved in the final stages of cell division to maintain genomic stability.