Functional characterization of SSB2: a novel single-stranded DNA binding protein

SSB2 的功能表征：一种新型单链 DNA 结合蛋白

• 批准号: DP1096661
• 负责人: Adj/Prof Kum Kum Khanna
• 金额: $ 21.57万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1096661
• 关键词: Functional; characterization; SSB2; novel; single

Defects in the DNA damage response pathway underpin many human genetic disorders and diseases. A detailed understanding of this pathway has enormous implications for future medicine. The proposed research will lead to functional characterization of a new protein, identify new concepts in DNA damage repair pathways, train young researchers and place Australia among the leaders in this internationally significant and highly competitive area of research. It will underpin the national research priority of Promoting and Maintaining Good Health and help Australia capitalise on a plethora of opportunities for future economic and health benefits.

DNA损伤反应途径的缺陷是许多人类遗传性疾病和病症的基础。对这一途径的详细了解对未来的医学有着巨大的意义。拟议的研究将导致一种新蛋白质的功能表征，确定DNA损伤修复途径的新概念，培训年轻的研究人员，并使澳大利亚成为这一具有国际意义和高度竞争力的研究领域的领导者。它将支持促进和保持良好健康的国家研究重点，并帮助澳大利亚利用未来经济和健康利益的大量机会。