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Synthesis and precision casting of bioactive glasses and the impact of the microstructured surfaces on cellular behaviour

生物活性玻璃的合成和精密铸造以及微结构表面对细胞行为的影响

基本信息

批准号：
245108579
负责人：
Professor Dr.-Ing. Andreas Bührig-Polaczek
金额：
--
依托单位：
Lehr- und Forschungsgebiet Zahnärztliche Werkstoffkunde und Biomaterialforschung
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2013
资助国家：
德国
起止时间：
2012-12-31 至 2016-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/245108579?language=en
关键词：
Synthesis precision casting bioactive glasses

项目摘要

The aim of the project is to synthesise and microstructure bioactive glasses using precision casting to investigate the complex interactions between a bioactive/bioresorbable surface of an implant material and neighbouring cells regarding a subsequent in vivo application.In a pilot study the three working groups (ZWBF, GI, GHI) have investigated the structuring of bioactive glass by the use of casting techniques. A glass matching the composition of Bioglass 45S5 (Hench glass) was synthesized and manually casted in a ceramic mould with a lamellar structure of 120 µm. The casted specimens proved that in principle precision casting is suitable for the manufacturing of glass bodies with a microstructured surface. Yet, accuracy and mould removal are still an issue. Therefore, further research activities have to focus on glass synthesis, mould manufacturing and the casting technology.In the applied project, glasses of the Na2O-CaO-SiO2-P2O5 system, established for clinical use, will be synthesized in combination with additional biologically stimulating elements, e. g. potassium and strontium. The impact of glass composition and surface structure on cell interaction will be investigated in detail. Precision casting will be applied to shape glasses with a specific microstructure. Various moulding techniques to obtain microstructures in different scales will be investigated. The mould materials will be analyzed regarding wettability and reactivity with the bioglass melts. The analyzation will be supported by computer assisted simulations. The surface structures will be adjusted to control the cellular response. Therein the particular focus is the osteogenic stimulation of bone-building cells by specifically designed microscopic structures. The corrosion behaviour of the surfaces will be analyzed under aqueous as well as physiological conditions and the underlying physical mechanisms are investigated. The objective of the research project is to evaluate all aspects relevant for the surface structure of a bioactive/resorbable glass implant with respect to the applied materials, the production process and the biological impact.

该项目的目的是使用精密铸造来合成和微结构化生物活性玻璃，以研究植入材料的生物活性/生物可吸收表面与邻近细胞之间的复杂相互作用，从而实现随后的体内应用。在一项试点研究中，三个工作组（ZWBF，GI，GHI）通过使用铸造技术研究了生物活性玻璃的结构。合成与Bioglass 45 S5（Hench玻璃）成分匹配的玻璃，并在陶瓷模具中手动铸造，具有120 µm的层状结构。铸造的样品证明，精密铸造原则上适用于制造具有微结构化表面的玻璃体。然而，精度和模具去除仍然是一个问题。因此，今后的研究重点应放在玻璃合成、模具制造和铸造技术上，在应用项目中，将合成临床使用的Na_2 O-CaO-SiO_2-P_2O_5系统玻璃，并添加生物刺激元素，如：钙钛矿、钙钛矿、钙钛矿等。G. 钾和锶将详细研究玻璃组成和表面结构对细胞相互作用的影响。精密铸造将应用于具有特定微观结构的成形玻璃。将研究各种模塑技术以获得不同尺度的微观结构。将分析模具材料的润湿性和与玻璃熔体的反应性。分析将由计算机辅助模拟支持。将调整表面结构以控制细胞反应。其中特别关注的是通过专门设计的微观结构对骨形成细胞的成骨刺激。将在水溶液和生理条件下分析表面的腐蚀行为，并研究潜在的物理机制。该研究项目的目的是评价与生物活性/可吸收玻璃植入物表面结构相关的所有方面，包括所用材料、生产工艺和生物学影响。