Enantioselective Conversion of Achiral Diketones and Triketones for Shortened Bioactive Molecule Synthesis

非手性二酮和三酮的对映选择性转化以缩短生物活性分子的合成

• 批准号: 245372425
• 负责人: Professor Dr. Thomas Nugent
• 金额: --
• 依托单位: Department of Life Sciences and Chemistry
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2013
• 资助国家: 德国
• 起止时间: 2012-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/245372425?language=en
• 关键词: Enantioselective; Conversion; Achiral; Diketones; Triketones

The constant demand for new and more complex enantiopure pharmaceutical drugs has made enantioselective organic methodology a high growth area, which is supported by academic granting agencies. In this context, the discovery and development of sustainable enantioselective methods (reduced environmental impact chemistry) is a current and ever increasing theme within chemistry. In this context water is an interesting solvent because of its availability and potential for allowing the development of green methods. This project fits into the above noted themes and is a request to develop promising organocatalysts for aldol and related reactions. The forwarding looking goal of this project is to allow greater design flexibility with improved efficiency for the synthesis of pharmaceutical drugs and natural products with reduced environmental impact.

对新的和更复杂的对映体纯药物的不断需求使对映体选择性有机方法学成为一个高增长领域，并得到学术资助机构的支持。在这种情况下，发现和发展可持续的对映选择性方法（减少环境影响的化学）是化学领域当前和不断增长的主题。在这种情况下，水是一种令人感兴趣的溶剂，因为它的可用性和潜力，使绿色方法的发展。本项目符合上述主题，是开发有前途的羟醛及相关反应的有机催化剂的要求。该项目的前瞻性目标是允许更大的设计灵活性，提高药物和天然产物合成的效率，减少对环境的影响。