Enantioselective Ammonium Enolate Based Michael-Henry and Michael-Henry-Aldol Cascade Reactions: Development, Mechanistic Insight, and Applications for Morphine Family Analgesics

鉴于医学对社会的重要性，有效合成与医学相关的分子一直是学术资助机构的重要目标。为了实现这一目标，综合设计原则与富有洞察力的策略相结合，它们的执行使学生接触到面对下一代更高级挑战所需的学习成果。如果没有这些类型的项目，一些药物根本不会被发现，或者被发现但永远不会推向市场用于治疗疾病。在这种背景下，对吗啡类似物的研究至今仍有增无减，并促使我们为合成吗啡提供了一种高效的新合成策略。一个成功的项目结果将允许这些发现被应用于合成以前无法获得的吗啡类似物作为候选药物进行药物化学探索。

Given the significance of medicine to society, the efficient synthesis of molecules of medicinal relevance has always been a vital goal within academic granting agencies. To reach that goal, synthetic design principles are coupled with insightful strategy, and their execution exposes students to the learning outcomes required to face the next generation of more advanced challenges. Without these types of projects, some pharmaceutical drugs would simply not be discovered or discovered but never brought to market for the treatment of disease. In this context, the study of morphine analogs continues unabated to this day and has motivated us to contribute a highly step-efficient new synthetic strategy for the synthesis of morphine. A successful project outcome would allow the findings to be applied to the synthesis of previously inaccessible morphine analogs for medicinal chemistry exploration as drug candidates.