Thyroid disruption in developing zebrafish (Danio rerio) - consequences on morphology, physiology and behavior

事实上，环境污染物可以破坏鱼类的甲状腺系统是众所周知的。较少人知道的是甲状腺破坏的发育，生理和行为后果。由于甲状腺系统在生长、发育和生殖等关键生理过程中起着重要作用，其环境诱导的破坏可能会影响各种健康和健身相关参数，如幼虫存活、变态、行为或生育力。由于选择性死亡，这些生物体水平的变化可以传播到改变的人口统计学中。拟议项目的目的是调查如何启动甲状腺破坏鱼类的分子途径导致发育和生理紊乱，导致健身变化。将研究两种作用模式：干扰甲状腺激素合成和与甲状腺激素受体结合。斑马鱼将被用作实验模型，应用一套分子，生理和行为方法。

The fact that environmental contaminants can disrupt the thyroid system of fish is well established. Less known are the developmental, physiological and behavioral consequences of thyroid disruption. As the thyroid system plays an important role in key physiological processes such as growth, development and reproduction, its environmentally induced disruption can impact a variety of health and fitness-related parameters such as larval survival, metamorphosis, behavior or fertility. These organism-level changes can then propagate into altered population demography due to selective mortality. The aim of the proposed project is to investigate how initiating molecular pathways of thyroid disruption in fish result in developmental and physiological disturbances leading to fitness changes. Two modes of action will be studied: interference with thyroid hormone synthesis, and binding to thyroid hormone receptors. Zebrafish will be used as experimental model, applying a suite of molecular, physiological, and behavioral approaches.