Borylative Heterocyclization Reactions

在化学系化学合成（SYN）项目的支持下，Suzanne A.位于欧文的加州大学的Blum将与研究生一起设计新的化学反应，制造含硼分子。这些含硼的新分子对于药物发现和下一代先进材料的构建具有重要意义。在这项研究中，将开发新的化学方法，将硼插入分子中目前不可能的位置。同时，将获得关于如何操纵化学反应以将硼插入到分子中所需但目前无法获得的位置的基本知识。由此积累的基础知识将可能有助于硼的化学反应发展，远远超出本研究项目。通过创建教学职业研讨会和圆桌会议系列，将实现更广泛的影响和社会效益。Blum教授将与研究生一起开发新的硼/元素加成反应。从这些反应中产生的产物将是硼基化的有机结构单元，可用于药物发现和材料合成。这种化学反应是指通过硼化杂环化反应将硼/氧、硼/氮和硼/硫加成到碳-碳键上。预计同时进行的机理研究将产生关于这些转化中中间体反应性的基础知识，这些基础知识适用于开发反应设计。这些研究将汇集布鲁姆教授实验室在有机合成、有机金属化学、机理研究和反应开发方面的多种专业知识，以解决这些具有挑战性的科学实验。布鲁姆教授在加州大学欧文分校（UCI）成功的未来教师培训计划的扩展对社会产生了更广泛的影响。在教学研讨会的职业生涯的创建将由该计划独特地启用，它将解决在UCI研究生和博士后学者的专业发展，否则未得到满足的需求。具体来说，一系列研讨会和圆桌会议将为研究生和博士后学者提供网络，教育和指导机会，包括传统上代表性不足的群体参与科学的重点机会。该奖项反映了NSF的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

With the support of the Chemical Synthesis (SYN) program in the Division of Chemistry, Professor Suzanne A. Blum of the University of California, Irvine, will work with graduate students to design new chemical reactions that make molecules containing boron. These new molecules with boron are important for applications in drug discovery and the construction of the next generation of advanced materials. In this research, new chemical methods will be developed, which insert boron at positions in molecules that are not currently possible. Concurrently, fundamental knowledge will be gained about how to manipulate chemical reactions to insert boron at desirable, but currently unobtainable, positions in molecules. The fundamental knowledge thereby accrued will likely contribute to chemical reaction development with boron well beyond this research project. Additional broader impacts and societal benefits will be achieved through the creation of a Careers in Teaching seminar and roundtable series. Professor Blum will work with graduate students to develop new boron/element addition reactions. The products arising from these reactions will be borylated organic building blocks that are useful for drug discovery and materials synthesis. This chemistry is directed at the addition of boron/oxygen, boron/nitrogen, and boron/sulfur to carbon–carbon bonds through borylative heterocyclization reactions. Concurrent mechanistic studies are expected to generate fundamental knowledge about the reactivity of intermediates in these transformations that is suitable for developing reaction design. These studies will bring together the diverse expertise of Professor Blum’s laboratory in organic synthesis, organometallic chemistry, mechanistic investigation, and reaction development to address these challenging scientific experiments. The expansion of the Professor Blum’s successful future faculty teacher training program at the University of California, Irvine (UCI) forms an additional broader impact for society. The creation of a Careers in Teaching Symposium will be uniquely enabled by this program and it will address an otherwise unmet need for the professional development of graduate students and postdoctoral scholars at UCI. Specifically, a seminar and roundtable series will provide graduate students and postdoctoral scholars with networking, education, and mentorship opportunities, including focused opportunities for participation of traditionally underrepresented groups in the sciences.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.