Light-Induced Atroposelective N-Heterocyclization via Chiral Perovskite Nanocrystals

项目摘要和摘要 构建轴向手性N-杂环分子的新方法可以具有 对药物活性化合物和其他物质的生产产生重大影响 有用的有机络合物。我们的研究计划将开发一种可见光诱导 直接生成手性N-杂环的催化反应方法 在其他方面都是具有挑战性的生产。该方法使用手性半导体 作为催化剂的钙钛矿型材料直接来自于已探明的太阳能 电池材料是台式可实现的和经济的生产。在建议的 策略，有机底物接近钙钛矿的手性表面进行电荷转移， 从而导致识别手性构型的关键步骤，从而导致 直接光诱导的不对称闭环反应。史无前例的反应 这里介绍的策略是同类策略中的第一个，具有广泛引入的潜力 重要的轴向手性生物相关化合物的一系列新的不对称反应， 可以认为是适合于药物合成的可靠的关键反应。

Project Summary and Abstract Novel method for constructing axially chiral N-heterocyclic molecules can have a significant impact on the manufacture of pharmaceutical-active compounds and other useful organic complexes. Our research program will develop a visible light induced catalytic reaction approach that leads to the direct formation of chiral N-heterocycles that were otherwise challenging to produce. The approach uses chiral semiconductor perovskite materials as the catalyst which are directly derived from well-explored solar cell materials that are bench-top achievable and economical to produce. In the proposed strategy, organic substrates approach perovskite’s chiral surface for charge transfer, leading to the key step for discriminate chiral configuration and thereby resulting in a direct light-induced asymmetric ring-closure reaction. The unprecedented reaction strategy described here is among the first of its kind, has the potential to introduce a wide range of new asymmetric reactions for important axially chiral bio-relevant compounds, and may be considered reliable linchpin reactions suitable for pharmaceutical synthesis.