Light-Induced Atroposelective N-Heterocyclization via Chiral Perovskite Nanocrystals

项目概要和摘要 用于构建轴向手性N-杂环分子的新方法可以具有 对生产药物活性化合物和其他 有用的有机络合物。我们的研究计划将开发一种可见光诱导的 催化反应方法，导致直接形成手性N-杂环， 否则很难生产。该方法使用手性半导体 作为催化剂的钙钛矿材料直接来自于充分探索的太阳能 可在工作台上实现且生产经济的电池材料。拟议 策略，有机基底接近钙钛矿的手性表面进行电荷转移， 从而导致识别手性构型的关键步骤，从而导致 直接光诱导的不对称闭环反应。前所未有的反应 这里描述的战略是同类中的第一个，有可能引入广泛的 一系列重要的轴向手性生物相关化合物的新的不对称反应， 并且可以被认为是适用于药物合成的可靠的关键反应。

Project Summary and Abstract Novel method for constructing axially chiral N-heterocyclic molecules can have a significant impact on the manufacture of pharmaceutical-active compounds and other useful organic complexes. Our research program will develop a visible light induced catalytic reaction approach that leads to the direct formation of chiral N-heterocycles that were otherwise challenging to produce. The approach uses chiral semiconductor perovskite materials as the catalyst which are directly derived from well-explored solar cell materials that are bench-top achievable and economical to produce. In the proposed strategy, organic substrates approach perovskite’s chiral surface for charge transfer, leading to the key step for discriminate chiral configuration and thereby resulting in a direct light-induced asymmetric ring-closure reaction. The unprecedented reaction strategy described here is among the first of its kind, has the potential to introduce a wide range of new asymmetric reactions for important axially chiral bio-relevant compounds, and may be considered reliable linchpin reactions suitable for pharmaceutical synthesis.