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New Boron-Element Addition Reactions

新的硼元素加成反应

基本信息

批准号：
1665202
负责人：
Suzanne Blum
金额：
$ 42.41万
依托单位：
University of California-Irvine
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2017
资助国家：
美国
起止时间：
2017-07-01 至 2022-06-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1665202&HistoricalAwards=false
关键词：
New Boron Element Addition Reactions

项目摘要

Modern materials with technologically advanced properties, and new pharmaceutical compounds to treat human disease, are all constructed through the combination of relatively small building blocks into larger and more complex structures. These combinations are limited by the types of small building blocks available. Thus, the ability to construct new advanced materials and to generate new pharmaceuticals is, in turn, limited by the variety of small building blocks available. In this project, Dr. Blum is developing new processes to create classes of new building blocks. These new building blocks are designed to be combined and thus to construct larger, complex materials and therapeutic agents with improved properties. The new processes involve sustainable approaches to synthesis by using Earth-abundant additives or, in some cases, by being additive-free. Dr. Blum is the director of a teacher-training program that provides current advanced students at the University of California, Irvine, with pedagogical training, mentorship, and skills for teaching the next generation of college students. This teacher-training program focuses on training in effective classroom instruction in the chemical sciences, including the instruction of scientific concepts developed in the research laboratory. With funding from the Chemical Synthesis Program in the Chemistry Division of the National Science foundation, Dr. Blum of the University of California, Irvine, is developing new boron-heteroatom addition reactions. The products from these reactions are borylated building blocks that are useful for drug discovery and materials synthesis. These reactions develop the previously unknown addition chemistry of boron-oxygen sigma bonds to carbon-carbon pi bonds, and extend this addition chemistry to boron-nitrogen addition reactions. Mechanistically distinct formal addition reactions of the equivalents of boron/oxygen, boron/nitrogen, and boron/sulfur are also being developed to access similar product classes and the two methods (direct and formal) are compared for efficiency. Studies include the development of these reactions with catalyst-free conditions, which provide a more sustainable approach than alternative traditional precious-metal-catalyzed borylation strategies. Dr. Blum is the director of a teacher-training program that provides current Ph.D. students at the University of California, Irvine, with pedagogical training, mentorship, and skills for teaching the next generation of college students. This teacher-training program focuses on training in effective classroom instruction in the chemical sciences, including the instruction of scientific concepts developed in the research laboratory.

具有先进技术性能的现代材料，以及治疗人类疾病的新型药物化合物，都是通过将相对较小的积木组合成更大、更复杂的结构来构建的。这些组合受到可用的小型构建块类型的限制。因此，构建新的先进材料和生产新药物的能力反过来又受到可用小构件的多样性的限制。在这个项目中，布鲁姆博士正在开发新的流程，以创建新的构建块类别。这些新的构建块被设计成组合在一起，从而构建更大的、具有更好性能的复杂材料和治疗剂。新的工艺涉及可持续的合成方法，通过使用地球上丰富的添加剂，或者在某些情况下，通过不添加添加剂。布鲁姆博士是加州大学欧文分校一个教师培训项目的负责人，该项目为加州大学欧文分校目前的高级学生提供教学培训、指导和教授下一代大学生的技能。这一教师培训方案侧重于在化学科学的有效课堂教学方面的培训，包括在研究实验室开发的科学概念的教学。在国家科学基金会化学部化学合成计划的资助下，加州大学欧文分校的布鲁姆博士正在开发新的硼-杂原子加成反应。这些反应的产物是硼化的积木，对药物发现和材料合成有用。这些反应发展了以前未知的硼-氧西格马键到碳-碳pi键的加成化学，并将这种加成化学扩展到硼-氮加成反应。为了获得相似的产品类别，还开发了在机械上不同的B/O、B/N和B/S当量的形式加成反应，并对两种方法(直接和形式)的效率进行了比较。研究包括在无催化剂的条件下开发这些反应，这提供了一种比传统的贵金属催化的硼化反应更可持续的方法。布鲁姆博士是一个教师培训项目的负责人，该项目为加州大学欧文分校的现有博士生提供教学培训、指导和教授下一代大学生的技能。这一教师培训方案侧重于在化学科学的有效课堂教学方面的培训，包括在研究实验室开发的科学概念的教学。