New Boron-Element Addition Reactions

具有先进技术性能的现代材料，以及治疗人类疾病的新药物化合物，都是通过将相对较小的构件组合成更大更复杂的结构来构建的。这些组合受到可用的小构件类型的限制。因此，构建新的先进材料和生产新药物的能力反过来又受到各种可用的小构件的限制。在这个项目中，Blum博士正在开发新的过程来创建新的构建块类。这些新的构建模块被设计为组合，从而构建具有改进性能的更大，复杂的材料和治疗剂。这些新工艺采用可持续的合成方法，使用地球上丰富的添加剂，或在某些情况下不使用添加剂。Blum博士是一个教师培训项目的负责人，该项目为加州大学欧文分校的高级学生提供教学培训、指导和教授下一代大学生的技能。 这个教师培训计划的重点是在化学科学有效的课堂教学培训，包括在研究实验室开发的科学概念的指令。在国家科学基金会化学部化学合成计划的资助下，加州大学欧文分校的Blum博士正在开发新的硼-杂原子加成反应。这些反应的产物是硼基化的结构单元，可用于药物发现和材料合成。这些反应发展了以前未知的硼-氧σ键与碳-碳π键的加成化学，并将这种加成化学扩展到硼-氮加成反应。也正在开发硼/氧、硼/氮和硼/硫当量的机械上不同的正式加成反应，以获得类似的产品类别，并比较两种方法（直接和正式）的效率。研究包括在无催化剂条件下开发这些反应，这提供了比替代传统贵金属催化硼基化策略更可持续的方法。布鲁姆博士是一个教师培训项目的负责人，该项目提供当前的博士学位。学生在加州大学欧文分校，与教学培训，导师，和技能，为教学的下一代大学生。 这个教师培训计划的重点是在化学科学有效的课堂教学培训，包括在研究实验室开发的科学概念的指令。

Modern materials with technologically advanced properties, and new pharmaceutical compounds to treat human disease, are all constructed through the combination of relatively small building blocks into larger and more complex structures. These combinations are limited by the types of small building blocks available. Thus, the ability to construct new advanced materials and to generate new pharmaceuticals is, in turn, limited by the variety of small building blocks available. In this project, Dr. Blum is developing new processes to create classes of new building blocks. These new building blocks are designed to be combined and thus to construct larger, complex materials and therapeutic agents with improved properties. The new processes involve sustainable approaches to synthesis by using Earth-abundant additives or, in some cases, by being additive-free. Dr. Blum is the director of a teacher-training program that provides current advanced students at the University of California, Irvine, with pedagogical training, mentorship, and skills for teaching the next generation of college students. This teacher-training program focuses on training in effective classroom instruction in the chemical sciences, including the instruction of scientific concepts developed in the research laboratory. With funding from the Chemical Synthesis Program in the Chemistry Division of the National Science foundation, Dr. Blum of the University of California, Irvine, is developing new boron-heteroatom addition reactions. The products from these reactions are borylated building blocks that are useful for drug discovery and materials synthesis. These reactions develop the previously unknown addition chemistry of boron-oxygen sigma bonds to carbon-carbon pi bonds, and extend this addition chemistry to boron-nitrogen addition reactions. Mechanistically distinct formal addition reactions of the equivalents of boron/oxygen, boron/nitrogen, and boron/sulfur are also being developed to access similar product classes and the two methods (direct and formal) are compared for efficiency. Studies include the development of these reactions with catalyst-free conditions, which provide a more sustainable approach than alternative traditional precious-metal-catalyzed borylation strategies. Dr. Blum is the director of a teacher-training program that provides current Ph.D. students at the University of California, Irvine, with pedagogical training, mentorship, and skills for teaching the next generation of college students. This teacher-training program focuses on training in effective classroom instruction in the chemical sciences, including the instruction of scientific concepts developed in the research laboratory.