Green and Sustainable Catalysts for Synthesis of Organic Building Blocks

用于合成有机砌块的绿色可持续催化剂

• 批准号: 246743874
• 负责人: Professor Dr. Hans-Joachim Knölker
• 金额: --
• 依托单位: Sächsische Akademie der Wissenschaften zu Leipzig
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2023-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/246743874?language=en
• 关键词: Green; Sustainable; Catalysts; Synthesis; Organic

Based on the results of the previous funding period, we envisage to establish iron-catalyzed dehydrogenative homo- and cross-coupling reactions of various substrates using oxygen as terminal oxidant. In particular, aryl/aryl, aryl/vinyl, aryl/alkyl and benzyl/benzyl cross-coupling reactions will be in the focus of this project. The feasibility of asymmetric syntheses will be explored using chiral iron catalysts and/or chiral additives. The newly established methods will be applied to the synthesis of organic synthetic building blocks and of selected natural products. In addition, we will investigate iron-catalyzed selective oxygenation and nitrogenation reactions including C(sp3)–H bond activation. Another goal is the application of our iron-catalyzed Wacker-type reaction to the synthesis of natural products. The design of novel iron-complexes to generate fine-tuned catalysts for the envisaged transformations is a crucial element of this project.

基于上一资助期的结果，我们设想使用氧气作为终端氧化剂建立各种底物的铁催化脱氢均相和交叉偶联反应。特别是，芳基/芳基、芳基/乙烯基、芳基/烷基和苄基/苄基交叉偶联反应将是该项目的重点。将使用手性铁催化剂和/或手性添加剂探索不对称合成的可行性。新建立的方法将应用于有机合成结构单元和精选天然产物的合成。此外，我们将研究铁催化的选择性氧化和氮化反应，包括 C(sp3)-H 键活化。另一个目标是将我们的铁催化瓦克型反应应用于天然产物的合成。设计新型铁配合物以产生用于预期转化的微调催化剂是该项目的关键要素。