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Flow Control through ultrasound-driven microbubble streaming

通过超声波驱动的微泡流进行流量控制

基本信息

批准号：
247225591
负责人：
Professor Dr. Christian Joachim Kähler
金额：
--
依托单位：
Institut für Strömungsmechanik und Aerodynamik (LRT-7)
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2013
资助国家：
德国
起止时间：
2012-12-31 至 2020-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/247225591?language=en
关键词：
Flow Control through ultrasound driven

项目摘要

Microfluidics, the manipulation of gasses and liquids on the micro-scale, is revolutionizing the life sciences and the chemical industry. The miniaturization of the devices not only intends to reduce the size of the setups, but also to reduce the time for analysis, and the amount of chemical reagents. However, due to the small scales involved, manipulation of microscopic flows becomes a complex task. One of the most difficult problems to overcome is to achieve mixing of substances intimes scales shorter than those achieved by molecular diffusion. The aim of the current proposal is to induce chaotic advection in the microfluidic chips by exciting microbubbles with ultrasoundwaves. When a microbubble is acoustically excited a streaming flow is generated around it. By manipulating these complex flows different flow patterns with different mixing properties can be easily generated by simply manipulating the excitation frequencies. The homogenization obtained from an optimal mixing can be employed to avoid clogging when a solid suspension of microparticles passes through the microchannel. Furthermore, the high stresses generated by thebubble-streaming flow can be employed to break particle clusters that use to block narrow conducts in microfluidics channels. In order to measure, evaluate and optimize the mixing properties of the flows, front-edge experimental velocimetry techniques able to solve three dimensional flows and a large range of time scales will be employed.

微流体技术，即在微观尺度上操纵气体和液体，正在彻底改变生命科学和化学工业。设备的小型化不仅旨在减小装置的尺寸，而且还旨在减少分析时间和化学试剂的量。然而，由于所涉及的小尺度，操纵微观流动成为一项复杂的任务。要克服的最困难的问题之一是在比分子扩散更短的时间尺度上实现物质的混合。目前的建议的目的是诱导混沌平流的微流控芯片通过激发微气泡与超声波。微气泡在声激励下产生流动，通过操纵这些复杂的流动，可以很容易地通过控制激励频率来产生具有不同混合特性的不同流型。当微粒的固体悬浮液通过微通道时，可以采用从最佳混合获得的均质化来避免堵塞。此外，由气泡流动产生的高应力可以用来打破用于阻塞微流体通道中的窄传导的颗粒簇。为了测量、评估和优化流动的混合特性，将采用能够解决三维流动和大范围时间尺度的前沿实验测速技术。