SBIR Phase I: On-demand light-switchable adhesives

SBIR 第一阶段：按需光敏粘合剂

• 批准号: 2112317
• 负责人: Kaushik Mishra
• 金额: $ 25.6万
• 依托单位: Polylux LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-15 至 2022-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2112317&HistoricalAwards=false
• 关键词: SBIR; Phase; demand; light; switchable

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is to reduce the prevalence of medical adhesive related skin injuries (MARSI) caused by conventional medical adhesive dressings. MARSI occurs in 7% of all patients across all age groups and all healthcare settings, resulting in about 1.5 million injuries annually in United States alone. It is estimated that in 2012 about $850 million in payments to hospitals were withheld due to low patient satisfaction scores because of MARSI. The average tape-induced skin injury costs $88.50 to treat, which is 125x greater than the average cost of one roll of medical adhesive tape. This project aims to create photo-switchable adhesive dressings, which would significantly reduce MARSI, reducing overall healthcare costs through nurse efficiencies, accelerating healing, improving quality of life for patients, and decreasing use of opioid pain medications. Other industry sectors that have shown interest in photo-switchable adhesives include plastic bottle recycling, industrial sensors and productivity sensor solutions and flexible electronics manufacturing.This Small Business Innovation Research (SBIR) Phase I project presents a novel adhesive technology platform where adhesive characteristics during application and use can be decoupled from end of life / removal characteristics through photo-switching. This project differs drastically from other research endeavors to create dismantlable adhesives, which have drawbacks including high costs, difficulty or inability to scale, insufficient safety to use in the medical industry, and inability to effect stimuli response within a short time. The proposed material meets all adhesive performance specifications and takes 2.5 minutes to photo-switch. Several crosslinker mixtures and emulsion morphologies will be explored to reduce adhesion switch time, in agreement with specifications needed for broad use. The cost and amounts of crosslinkers needed, along with process control complexity, will be studied to optimize for both switching speed and cost to manufacturing. Prototype medical dressings will be prepared by coating medical grade facestock and will be characterized and tested to optimize performance. Finally, the product will be sent for ISO 10993 tests to prove the pre-clinical safety and efficacy of the dressings on an open wound.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这项小型企业创新研究（SBIR）I期项目的更广泛的影响/商业潜力是减少由常规的医学粘合剂敷料引起的医学粘合剂相关皮肤损伤（MARSI）的患病率。 MARSI发生在所有年龄段和所有医疗保健环境中的所有患者中，有7％发生，仅在美国，每年约有150万次受伤。据估计，由于Marsi的患者满意度得分较低，因此在2012年，向医院支付了约8.5亿美元的付款。胶带引起的皮肤损伤的平均治疗费用为88.50美元，比一卷胶带的平均成本高125倍。该项目旨在创建可切换的粘合剂敷料，从而大大降低MARSI，从而通过护士效率降低整体医疗保健成本，加快愈合，改善患者的生活质量以及减少使用阿片类止痛药。其他行业对可拍照的胶粘剂表现出兴趣的其他行业，包括塑料瓶回收，工业传感器和生产力传感器解决方案以及灵活的电子制造。该小型企业创新研究（SBIR）I阶段项目提出了一个新颖的粘合技术平台，在该平台中，在应用程序和使用过程中，可以通过摄影 /重新覆盖的特征来消除粘合性特征，从而可以通过摄影 /重新覆盖的特征来通过照片 / rebovalssications vys-Switching进行分解。该项目与其他研究的努力截然不同，以创建可拆卸的粘合剂，这些粘合剂具有高成本，难度或无法扩展的缺点，在医疗行业使用的安全性不足以及无法在短时间内实现刺激反应。提议的材料符合所有粘合性性能规格，并需要2.5分钟才能进行照相开关。将探索几种交联的混合物和乳液形态，以减少粘附切换时间，这与广泛使用所需的规格一致。将研究所需的交联的成本和数量以及过程控制复杂性，以优化开关速度和制造成本。原型医疗敷料将通过涂层医学级面孔制备，并将经过特征和测试以优化性能。最后，该产品将用于ISO 10993测试，以证明盛装敷料在开放伤口上的临时安全性和功效。该奖项反映了NSF的法定任务，并被认为是通过基金会的智力优点和更广泛的影响标准通过评估来通过评估来支持的。