SBIR Phase I: AuraPeel - On-Demand Light Switchable Adhesives

这个小型企业创新研究(SBIR)第一阶段项目将研究新型光可切换粘合剂在医用敷料中的使用，以提高患者的安全性、医院遵从性，并可能改变粘合敷料领域的护理标准。这项拟议的工作与其他制造可拆卸粘合剂的研究工作截然不同，其缺点包括高成本、难以规模化、生物兼容性问题以及无法在短时间内实现应用切换。这项新的研究提供了显著降低成本和使用现成的粘合剂行业基础设施更容易扩大规模的优势。医用粘合敷料容易失去剥离粘连，解决了预防医用粘连相关皮肤损伤(MARSI)的重大未得到满足的需求，MARSI是一种普遍但未被认识到的损伤，影响所有年龄组和医疗保健环境中7%的患者。仅在美国，马西每年就造成约150万人受伤，据估计，由于患者满意度低，马西导致医院扣留了8.5亿美元的费用。该项目正在寻求一种医用敷料的创造，以解决这些问题，同时具有成本竞争力，易于使用，最重要的是，对患者的皮肤安全。原型医疗敷料将根据客户要求进行表征和测试。这个小型企业创新研究第一阶段项目提供了一个新的粘合剂技术平台，通过光切换将应用时的用例特征与寿命结束/移除特征分离。可光切换的医用粘合剂敷料可在光照下失去剥离粘附性，满足了预防医用粘合剂相关皮肤损伤(MARSI)的重大需求，MARSI是一种普遍但未被认识到的损伤，影响所有年龄组和医疗保健环境中7%的患者。这项拟议的工作与其他创造可拆卸粘合剂的研究工作截然不同，因为专有的可光切换分子能够在短时间内改变人体安全条件。拟议的第一阶段SBIR项目将评估不同的专利多功能交联剂，以将光开关的速度提高约50%，以满足临床医生的需求。在此之后，将对粘合衬里薄膜的制备方法进行实验评估，以实现在不同厚度和不同衬底下的最佳光学开关。最后，从上述两个步骤中学到的关于胶粘涂层薄膜的知识将与现有的护肤灯相结合，以演示产品的证明。产品性能将根据客户要求进行表征和测试，以优化性能。该奖项反映了NSF的法定使命，并已通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

This Small Business Innovation Research (SBIR) Phase I project will investigate the use of novel photo-switchable adhesives in medical dressings to improve patient safety, hospital compliance and potentially change the standard of care in the field of adhesive dressings. The proposed work differs drastically from other research endeavors to create dismantlable adhesives, whose drawbacks include high costs, difficulty to scale, biocompatibility issues, and inability to effect switching in application within short times. This new research offers advantages of significantly lower costs and easier scale-up using readily available adhesive industry infrastructure. Medical adhesive dressings that easily lose peel adhesion addresses a significant unmet need for preventing medical adhesive related skin injuries (MARSI), a prevalent but under-recognized injury that affects 7% of all patients across all age groups and healthcare settings. MARSI causes about 1.5 million injuries annually in the US alone and it is estimated that MARSI caused $850M in payments withheld to hospitals due to low patient satisfaction. This project is pursing the creation of a medical dressing that addresses these concerns while being cost competitive, easy to use and most importantly, safe to the patient's skin. Prototype medical dressings will be characterized and tested based on customer requirements.This Small Business Innovation Research Phase I project presents a novel adhesive technology platform where use-case characteristics at application are decoupled from end of life/removal characteristics through photo-switching. Photo-switchable medical adhesive dressings that lose peel adhesion upon application of light address a significant unmet need for preventing medical adhesive related skin injuries (MARSI), a prevalent but under-recognized injury that affects 7% of all patients across all age groups and healthcare settings. The proposed work differs drastically from other research endeavors to create dismantlable adhesives as the proprietary photo-switchable molecules enable change in human safe conditions and in short time frames. The proposed Phase 1 SBIR project would evaluate different proprietary multifunctional crosslinkers to increase the speed of the photo-switch by about 50% to meet clinician needs. This would be followed by experimentally evaluating methodologies to fabricate adhesive lined films for optimal optical switchability at different thicknesses and for different substrates. Finally, the learnings from the above two steps about adhesive coated films will be combined with an existing skincare lamp to demonstrate proof of product. Product performance will be characterized and tested to optimize performance based on customer requirements.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.