SBIR Phase I: AuraPeel - On-Demand Light Switchable Adhesives

这项小型企业创新研究（SBIR）第一阶段项目将研究在医用敷料中使用新型光开关粘合剂，以提高患者安全性、医院合规性，并有可能改变医用敷料领域的护理标准。这项工作与其他制造可拆卸粘合剂的研究工作有很大的不同，后者的缺点包括成本高、难以规模化、生物相容性问题，以及无法在短时间内实现应用转换。这项新研究提供了显著降低成本和更容易扩大规模的优势，使用现成的粘合剂工业基础设施。易失去剥离附着力的医用胶粘剂敷料解决了预防医用胶粘剂相关皮肤损伤（MARSI）的重大未满足需求，这是一种普遍存在但未得到充分认识的损伤，影响了所有年龄组和医疗保健机构中7%的患者。仅在美国，MARSI每年就造成约150万起伤害，据估计，由于患者满意度低，MARSI导致了8.5亿美元的医院付款被扣留。该项目旨在创造一种医用敷料，解决这些问题，同时具有成本竞争力，易于使用，最重要的是，对患者的皮肤安全。原型医用敷料将根据客户要求进行特征和测试。这个小企业创新研究第一阶段项目展示了一种新型的粘合剂技术平台，该平台通过光交换将应用中的用例特征与生命周期结束/去除特征分离开来。光开关医用胶粘剂敷料在应用光后失去剥离附着力，解决了预防医用胶粘剂相关皮肤损伤（MARSI）的重大未满足需求，这是一种普遍存在但未得到充分认识的损伤，影响了所有年龄组和医疗保健机构中7%的患者。拟议的工作与其他创造可拆卸粘合剂的研究工作截然不同，因为专有的光开关分子可以在短时间内改变人类的安全条件。拟议的第一阶段SBIR项目将评估不同的专有多功能交联剂，以将光开关的速度提高约50%，以满足临床医生的需求。接下来将通过实验评估方法来制造粘合剂衬里薄膜，以在不同厚度和不同基材上获得最佳的光学开关性。最后，从以上两个步骤中学习到的关于粘合剂涂层的知识将与现有的护肤灯相结合，以演示产品的证明。对产品性能进行表征和测试，以根据客户要求优化性能。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This Small Business Innovation Research (SBIR) Phase I project will investigate the use of novel photo-switchable adhesives in medical dressings to improve patient safety, hospital compliance and potentially change the standard of care in the field of adhesive dressings. The proposed work differs drastically from other research endeavors to create dismantlable adhesives, whose drawbacks include high costs, difficulty to scale, biocompatibility issues, and inability to effect switching in application within short times. This new research offers advantages of significantly lower costs and easier scale-up using readily available adhesive industry infrastructure. Medical adhesive dressings that easily lose peel adhesion addresses a significant unmet need for preventing medical adhesive related skin injuries (MARSI), a prevalent but under-recognized injury that affects 7% of all patients across all age groups and healthcare settings. MARSI causes about 1.5 million injuries annually in the US alone and it is estimated that MARSI caused $850M in payments withheld to hospitals due to low patient satisfaction. This project is pursing the creation of a medical dressing that addresses these concerns while being cost competitive, easy to use and most importantly, safe to the patient's skin. Prototype medical dressings will be characterized and tested based on customer requirements.This Small Business Innovation Research Phase I project presents a novel adhesive technology platform where use-case characteristics at application are decoupled from end of life/removal characteristics through photo-switching. Photo-switchable medical adhesive dressings that lose peel adhesion upon application of light address a significant unmet need for preventing medical adhesive related skin injuries (MARSI), a prevalent but under-recognized injury that affects 7% of all patients across all age groups and healthcare settings. The proposed work differs drastically from other research endeavors to create dismantlable adhesives as the proprietary photo-switchable molecules enable change in human safe conditions and in short time frames. The proposed Phase 1 SBIR project would evaluate different proprietary multifunctional crosslinkers to increase the speed of the photo-switch by about 50% to meet clinician needs. This would be followed by experimentally evaluating methodologies to fabricate adhesive lined films for optimal optical switchability at different thicknesses and for different substrates. Finally, the learnings from the above two steps about adhesive coated films will be combined with an existing skincare lamp to demonstrate proof of product. Product performance will be characterized and tested to optimize performance based on customer requirements.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.