SBIR Phase I: AuraPeel - On-Demand Light Switchable Adhesives

SBIR 第一阶段：AuraPeel - 按需光可切换粘合剂

• 批准号: 1819822
• 负责人: Kaushik Mishra
• 金额: $ 22.5万
• 依托单位: Polylux LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-06-15 至 2020-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1819822&HistoricalAwards=false
• 关键词: SBIR; Phase; AuraPeel; Demand; Light

This Small Business Innovation Research (SBIR) Phase I project will investigate the use of novel photo-switchable adhesives in medical dressings to improve patient safety, hospital compliance and potentially change the standard of care in the field of adhesive dressings. The proposed work differs drastically from other research endeavors to create dismantlable adhesives, whose drawbacks include high costs, difficulty to scale, biocompatibility issues, and inability to effect switching in application within short times. This new research offers advantages of significantly lower costs and easier scale-up using readily available adhesive industry infrastructure. Medical adhesive dressings that easily lose peel adhesion addresses a significant unmet need for preventing medical adhesive related skin injuries (MARSI), a prevalent but under-recognized injury that affects 7% of all patients across all age groups and healthcare settings. MARSI causes about 1.5 million injuries annually in the US alone and it is estimated that MARSI caused $850M in payments withheld to hospitals due to low patient satisfaction. This project is pursing the creation of a medical dressing that addresses these concerns while being cost competitive, easy to use and most importantly, safe to the patient's skin. Prototype medical dressings will be characterized and tested based on customer requirements.This Small Business Innovation Research Phase I project presents a novel adhesive technology platform where use-case characteristics at application are decoupled from end of life/removal characteristics through photo-switching. Photo-switchable medical adhesive dressings that lose peel adhesion upon application of light address a significant unmet need for preventing medical adhesive related skin injuries (MARSI), a prevalent but under-recognized injury that affects 7% of all patients across all age groups and healthcare settings. The proposed work differs drastically from other research endeavors to create dismantlable adhesives as the proprietary photo-switchable molecules enable change in human safe conditions and in short time frames. The proposed Phase 1 SBIR project would evaluate different proprietary multifunctional crosslinkers to increase the speed of the photo-switch by about 50% to meet clinician needs. This would be followed by experimentally evaluating methodologies to fabricate adhesive lined films for optimal optical switchability at different thicknesses and for different substrates. Finally, the learnings from the above two steps about adhesive coated films will be combined with an existing skincare lamp to demonstrate proof of product. Product performance will be characterized and tested to optimize performance based on customer requirements.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这项小型企业创新研究（SBIR）I阶段项目将调查在医疗敷料中使用新颖的可开关粘合剂，以提高患者的安全，医院合规性，并可能改变粘合剂敷料领域的护理标准。拟议的工作与其他研究努力截然不同，以创建可拆卸的粘合剂，其缺点包括高成本，缩放难度，生物相容性问题以及无力在短时间内实现应用程序的转换。这项新的研究提供了使用易于使用的粘合性行业基础设施的成本明显降低和更容易扩展的优势。容易失去剥离粘附的医学粘合剂敷料解决了预防医学粘合剂相关皮肤损伤（MARSI）的重要需求，这是一种普遍但未被认可的损伤，影响所有年龄段和医疗保健环境中所有患者的7％。仅在美国，马西每年就会造成约150万次伤害，据估计，由于患者的满意度较低，马西造成了8.5亿美元的付款给医院。该项目正在追求一种医疗调味料的创建，该医疗调味料在竞争激烈，易于使用且最重要的是对患者皮肤安全的同时，以解决这些问题。原型医疗调味料将根据客户需求进行特征和测试。本小型企业创新研究阶段I项目提出了一个新颖的粘合技术平台，在该平台中，应用程序的用例特征从生命终结/删除特性通过照片切换而解耦。应用光线时会失去剥离粘附的可切换医学粘合剂敷料，这是预防医学粘合性相关皮肤损伤的重要需求（MARSI），这是一种普遍但不认可的损伤，影响了所有年龄段和医疗保健环境中所有患者的7％。拟议的工作与其他研究努力截然不同，以创建可拆解的粘合剂，因为可专用的可拍摄分子可以在人类安全条件和短时间内变化。拟议的第1阶段SBIR项目将评估不同的专有多功能交联链，以将照片开关的速度提高约50％，以满足临床医生的需求。随后将对方法进行实验评估，以制造粘合剂衬里的膜，以在不同厚度和不同底物下进行最佳的光学切换性。最后，从上面的两个步骤中进行的有关胶粘膜的步骤将与现有的护肤灯结合使用，以展示产品证明。产品性能将经过特征和测试，以根据客户需求优化性能。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的知识分子优点和更广泛的影响审查标准通过评估来获得支持的。