MRI: Acquisition of an EEG for Examination of Brain-Behavior Relationships Across the Lifespan

MRI：采集脑电图以检查整个生命周期中的大脑行为关系

• 批准号: 2117233
• 负责人: Renee Lajiness-O'Neill
• 金额: $ 14.99万
• 依托单位: Eastern Michigan University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2117233&HistoricalAwards=false
• 关键词: MRI; Acquisition; EEG; Examination; Brain

This Major Research Instrumentation award supports the acquisition of an Electroencephalography (EEG) system (ANT Neuro eego mylab128-channel) to establish the first EEG laboratory for brain imaging at Eastern Michigan University (EMU). EEG is a non-invasive human brain imaging method that measures neural electrical activity in the human brain arising from thinking and behavior with millisecond accuracy. The EEG laboratory critically expands neuroscience training and research in the Departments of Psychology, Communication Sciences and Disorders, and the interdisciplinary Neuroscience Program (Psychology, Biology, Chemistry). The EEG laboratory also has a substantial regional impact on the institutional community. EMU is recognized as one of the most diverse universities in the Midwest. The EEG laboratory allows EMU to contribute to the broader aims of the scientific community to recruit, retain, and promote members of minoritized groups into STEM fields. The laboratory allows for workshops to train local and regional faculty and students on neuroimaging, serve as a catalyst for the development of research assistantships and fellowships targeted for underrepresented students, including those from rural communities, and be central in creating a mentoring partnership with the McNair Scholars Program for students interested in EEG research. The EEG laboratory enhances collaborative research efforts within EMU, with partnering regional institutions, and foster national collaborations in developmental neuroscience.Knowledge of the brain mechanisms underlying fundamental cognitive and behavioral processes (e.g. attention and language) in infants/children and older adults, the precise timing of developmental changes, and knowledge of crucial environmental factors that impact this timing has lagged behind research with younger adults and remains a frontier of investigation. EEG is non-invasive and well-tolerated by infants and children. This team examines the EEG signals and developmental timing of key cognitive and behavioral processes including attention and working memory, motor control, self-regulation, sleep, and communication. EEG event-related potentials, frequency (power), and brain connectivity in developing neural networks are explored. The electrophysiological mechanisms (spectral power and connectivity) underpinning the development of the default mode and dorsal attention networks and orienting system in infancy/toddlerhood are examined to clarify the relationships between attention and social-communication. The neural correlates of change of bimanual and unimanual motor control across the lifespan as well as the neural underpinnings of inconsistent hand preference and hand dominance are being investigated. Investigators are examining developmental changes and environmental precursors of event-related potentials hypothesized to underlie self-regulation. Investigation of the functions of napping, including neurophysiology and behavior, in early childhood provide vital information on reciprocal relations between the development of sleep-wake regulation and the development of attention. Finally, few studies have examined the neurophysiological mechanisms underlying working memory-linguistic processes in older adults. EEG is being used to explore the long-term learning effects and the compensatory processes that occur in older adults.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这项重大研究仪器奖支持收购脑电图（EEG）系统（ANT Neuro eego mylab 128通道），以建立东密歇根大学（EMU）首个脑成像EEG实验室。EEG是一种非侵入性的人脑成像方法，它以毫秒级的精度测量人脑中由思维和行为引起的神经电活动。EEG实验室批判性地扩展了心理学，通信科学和疾病部门的神经科学培训和研究，以及跨学科的神经科学计划（心理学，生物学，化学）。EEG实验室也对机构社区产生了重大的区域影响。EMU被公认为是中西部最多样化的大学之一。EEG实验室允许EMU为科学界的更广泛目标做出贡献，以招募，保留和促进少数群体成员进入STEM领域。该实验室允许研讨会，以培训当地和区域的教师和学生神经成像，作为针对代表性不足的学生，包括来自农村社区的学生的研究助学金和奖学金的发展的催化剂，并在创建与麦克奈尔学者计划的指导伙伴关系中发挥核心作用对EEG研究感兴趣的学生。EEG实验室加强了EMU内部与合作区域机构的合作研究工作，并促进了发展神经科学方面的国家合作。（例如注意力和语言），发育变化的精确时间，对影响这一时间的关键环境因素的了解落后于对年轻人的研究，仍然是研究的前沿。EEG是非侵入性的，婴儿和儿童耐受性良好。该团队研究了EEG信号和关键认知和行为过程的发育时间，包括注意力和工作记忆，运动控制，自我调节，睡眠和沟通。EEG事件相关电位，频率（功率）和大脑连接在开发神经网络进行了探索。本研究探讨了婴儿期和幼儿期默认模式、背侧注意网络和定向系统发展的电生理机制（频谱功率和连接性），以阐明注意与社会交往之间的关系。双手和单手运动控制的变化在整个生命周期的神经相关性，以及不一致的手偏好和手优势的神经基础正在调查。研究人员正在研究假设为自我调节基础的事件相关电位的发展变化和环境前兆。对儿童早期午睡功能的研究，包括神经生理学和行为学的研究，为睡眠-觉醒调节的发展和注意力的发展之间的相互关系提供了重要信息。最后，很少有研究探讨老年人工作记忆-语言过程的神经生理机制。EEG被用于探索老年人的长期学习效果和代偿过程。该奖项反映了NSF的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。