MRI: Acquisition of a dual-acquisition high-density EEG with transcranial electrical neuromodulation for psychophysiological research.

这项国家科学基金重大研究仪器奖资助了北密歇根大学(NMU)收购具有高密度经颅电刺激(HD-TES)神经调制技术和时间锁定双采集能力的高密度脑电(HD-EEG)系统。EEG是一种非侵入性的测量大脑电活动的方法，具有极好的(毫秒级)时间分辨率。HD-TES的神经调节提供了一种非侵入性的方法，可以高精度地实验操作大脑活动，以评估神经激活和人类行为之间的因果联系。当两个(或更多)脑电设备被时间锁定时，这种被称为超扫描的方法可以洞察潜在的社会互动的神经机制。该奖项支持的仪器是具有HD-EEG、超扫描EEG和HD-TES功能的集成系统。北密歇根大学是一所以本科生为主的农村大学，拥有大量第一代和低收入家庭的学生。该奖项支持的仪器设备将显著改善NMU的研究环境，从而为未被充分代表的本科生提供创新和新兴神经科学技术的关键培训机会。该奖项支持的研究集成了HD-EEG、超扫描和HD-TES方法-代表了人类神经科学研究的新前沿，有可能通过测试二元社交环境中的因果大脑行为关系来改变该领域。该奖项支持教师和本科生在情感和认知神经科学领域以及心理学的社会认知、行为和应用领域的合作研究项目。在适应和不适应行为的背景下，基于脑电的奖励处理方法已经得到了广泛的研究。然而，这些基于奖励的脑电信号的潜在神经生成器仍然是一个争议点。该奖项支持的仪器提供了一个独特的机会，通过HD-TES对潜在的神经发生器进行电刺激，并评估神经调制对奖励处理的脑电测量的因果影响。神经调节对奖赏加工的因果效应在多种情境下被研究，包括简单的竞价任务、认知训练方案和模拟复发行为的操纵者更新范式。该奖项支持的研究利用该工具的超扫描能力来评估内在动机作为心理需求满足与挫折的函数的神经关联，通过涉及合作和竞争的二元社会互动。超扫描也被用来评估在二元社会环境中基于脑电的绩效监测措施的差异。研究探索了在合作与竞争的二元社会互动中，奖励加工和绩效监控来源的HD-TES目标可以在多大程度上调节内在动机和合作以及任务绩效。简而言之，该奖项支持的研究整合了HD-EEG、超扫描和HD-TES方法，目的是更好地了解参与奖励处理的神经系统和社会环境中对人类行为的绩效监控之间的因果关系。该奖项反映了NSF的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

This National Science Foundation Major Research Instrumentation award funds the acquisition of a high-density electroencephalogram (HD-EEG) system with high-density transcranial electric stimulation (HD-tES) neuromodulation technology and time-locked dual acquisition capabilities at Northern Michigan University (NMU). EEG is a non-invasive measure of the brain’s electrical activity with excellent (millisecond level) temporal resolution. Neuromodulation with HD-tES offers a non-invasive method of experimentally manipulating brain activity with high precision to assess the causal link between neural activation and human behavior. When two (or more) EEG devices are time-locked this method, known as hyperscanning, allows for insight into the neural mechanisms underlying social interactions. The instrumentation supported by this award is an integrated system with HD-EEG, hyperscanning EEG, and HD-tES functionality. Northern Michigan University, NMU, is a rural predominantly undergraduate institution with a large number of first-generation and low-income students. The instrumentation supported by this award will significantly enhance the research environment at NMU and in doing so provide critical training opportunities for underrepresented undergraduate students in innovative and emergent neuroscience techniques. The research supported by this award integrates across HD-EEG, hyperscanning, and HD-tES methodologies—representing a new frontier in human neuroscience research that has the potential to transform the field by testing for cause and effect brain-behavior relationships in dyadic social environments. This award supports collaborative research projects involving faculty and undergraduate students in the areas of affective and cognitive neuroscience as well as social-cogniton, behavioral, and applied fields of psychology. EEG based measures of reward processing have been extensively studied in the context of adaptive and maladaptive behavior. Yet, the underlying neural generator of these reward-based EEG signals remains a point of contention. The instrumentation supported by this award provides a unique opportunity to electrically stimulate potential neural generators via HD-tES and assess the causal effects of neuromodulation on EEG measures of reward processing. The causal effects of neuromodulation on reward processing are studied in multiple contexts including simple bidding tasks, cognitive training protocols, and operant renewal paradigms modeling relapse behavior. The research supported by this award utilizes the hyperscanning capabilities of the instrumentation to assess the neural correlates of intrinsic motivation as a function of psychological need fulfillment vs frustration via dyadic social interactions involving cooperation and competition. Hyperscanning is also used to assess differences in EEG-based measures of performance-monitoring in dyadic social environments. Studies explore the extent to which HD-tES targeting of reward processing and performance monitoring sources can be used to modulate intrinsic motivation and cooperation as well as task performance in cooperative vs competitive dyadic social interactions. In short, the research enabled by this award integrates across HD-EEG, hyperscanning, and HD-tES methodologies with the aim of better understanding the cause and effect relationship between the neural systems involved in reward processing and performance monitoring on human behavior in social contextsThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.