Doctoral Dissertation Research: Investigating the relationship between rural environments characterized by industrial agriculture and the timing of puberty

博士论文研究：以工业农业为特征的乡村环境与青春期时机的关系研究

• 批准号: 2122661
• 负责人: Andrea Wiley
• 金额: $ 1.65万
• 依托单位: Indiana University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2023-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2122661&HistoricalAwards=false
• 关键词: Doctoral; Dissertation; Research; Investigating; relationship

This award is funded in whole or in part under the American Rescue Plan Act of 2021 (Public Law 117-2). Puberty is known to be affected by nutritional status and psychosocial stress, but less is known about the role of rural environments and, specifically, exposure to chemicals that disrupt the endocrine system. This biocultural doctoral dissertation project explores how living in rural communities shaped by industrial agriculture impacts human growth and development. The investigators compare pubertal timing in agricultural communities that have high levels of endocrine-disrupting chemical exposure to non-agricultural communities in low-exposure areas. The research contributes new knowledge about variation in patterns of human reproduction, growth, and development. The findings can inform public health policy and public science outreach. The project includes the design of K-12 curricula on human biology and pesticides. Individuals from groups underrepresented in STEM include participants in the study as well as researchers who will be trained and mentored by the investigators. Endocrine-disrupting chemicals like pesticides can disrupt hormones that regulate puberty, are energetically costly to detoxify, and increase chronic disease risk in adulthood. The investigators use silicone wristbands and gas chromatography to measure exposure to endocrine-disrupting pesticides through skin or respiration among girls in communities with high and low pesticide use. The researchers evaluate and control for the roles of nutritional status, assessed using anthropometry and 24-hour dietary recalls, and psychosocial stress, measured using a variety of validated instruments. Participant observation is used to understand the local sociocultural context and differences in lived experiences between girls in the agricultural and non-agricultural communities.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项是根据2021年《美国救援计划法》（公法117-2）全部或部分资助的。已知青春期受到营养状况和社会心理压力的影响，但对农村环境的作用，尤其是破坏内分泌系统的化学物质的作用知之甚少。这个生物文化博士学位论文项目探讨了生活在工业农业塑造的农村社区中如何影响人类的成长和发展。研究人员比较农业社区中的青春期时间安排，这些农业社区的内分泌干扰水平很高，可在低暴露区域中的非农业社区暴露于化学界。该研究有助于有关人类繁殖，成长和发展模式变化的新知识。这些发现可以为公共卫生政策和公共科学外展提供信息。 该项目包括针对人类生物学和农药的K-12设计。来自STEM中人数不足的小组的个人包括研究参与者以及将由研究人员培训和指导的研究人员。诸如农药之类的内分泌化学物质会破坏调节青春期的激素，在成年后的昂贵昂贵，并增加成年后的慢性疾病风险。研究人员使用硅胶腕带和气相色谱法来测量使用高和低农药的社区中女孩的皮肤或呼吸中的内分泌干扰物的暴露。研究人员使用人体测量法和24小时饮食召回和心理社会压力评估并控制了营养状况的作用，并使用多种经过验证的工具进行了测量。参与者的观察被用来了解当地的社会文化背景以及农业和非农业社区中女孩之间生活经历的差异。该奖项反映了NSF的法定使命，并被认为是值得通过基金会的知识分子优点和更广泛影响的审查标准通过评估来进行评估的。