Collaborative Research: Role of Flexible Design and Instructor Supports in Implementing Sustainable Course-based Research Experiences Across Diverse Institution Types

协作研究：灵活设计和教师支持在跨不同机构类型实施可持续的基于课程的研究经验中的作用

• 批准号: 2142033
• 负责人: Paul Craig
• 金额: $ 58.86万
• 依托单位: Rochester Institute of Tech
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2142033&HistoricalAwards=false
• 关键词: Collaborative; Research; Role; Flexible; Design

This project aims to serve the national interest by implementing evidence-based teaching practices using course based undergraduate research experiences (CUREs). Students learn most effectively by doing rather than merely watching and listening. At the undergraduate level in sciences, this translates into learning science by doing science. It is well-known that undergraduates have improved outcomes in performance, persistence, and progress when they engage in hands-on research; that is, doing what scientists in any field do. These improved outcomes could be particularly valuable for students from minoritized groups and first-generation college students. At the same time, access to research experiences as undergraduates in the form of traditional apprenticeship-based laboratory research has historically favored majority-group students. CUREs have been shown to provide some of the same benefits as traditional research experiences, but at a much broader scale, at lower cost, and with shorter time commitments. This project will provide broad access to learning-by-doing in biochemistry research by lowering barriers to implementing CUREs. The project intends to assess participation in a previously developed biochemistry CURE, the Biochemistry Authentic Science Inquiry Laboratory (BASIL). The project will engage with faculty at institutions whose students will most benefit from increased access to research experiences, with a focus on Minority-Serving Institutions. The BASIL CURE is fully implemented on ten campuses. More than 25 other campuses are exploring and/or using parts of the curriculum through prior work. The project will add 50 more campuses to the project over the next 5 years through a series of recruiting and training workshops and through a well-designed mentoring program. The project will focus on Minority-Serving Institutions, Historically Black Colleges and Universities, Tribal Colleges, and Community Colleges. The goal of the project is to investigate the processes by which CUREs are adopted, implemented, and sustained with three specific aims: Aim 1. Identify the supports for and barriers to CURE implementation and sustainability across institution types; Aim 2. Characterize the relationship between institutional context and variations in CURE implementation across institution types; and Aim 3. Facilitate implementation and sustainability in diverse contexts through faculty development. The project will collect data from participating faculty by administering and collecting (a) pre-engagement surveys, (b) implementation plans, (c) implementation surveys, and (d) semi-structured interviews. The project will partner with other established CURE communities in the field to assess the process of CURE implementation for any barriers such as impacts of cost, institutional support, or faculty workload. The project will also assess the sustainability of the CURE strategy across participating campuses based on demographics, size, location, and other factors. As a result of this implementation and assessment process, the project seeks to contribute to strengthening the diverse workforce in sciences, technology, and medicine. The NSF IUSE: EHR Program supports research and development projects to improve the effectiveness of STEM education for all students. Through the Engaged Student Learning track, the program supports the creation, exploration, and implementation of promising practices and tools.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该项目旨在通过利用基于课程的本科生研究经验(CURE)实施循证教学实践来服务于国家利益。学生最有效的学习方式是做，而不仅仅是看和听。在本科生的理科水平上，这转化为通过做科学来学习科学。众所周知，当本科生从事实践研究时，他们在表现、毅力和进步方面都会有更好的结果；也就是说，做任何领域的科学家都会做的事情。这些改善的结果可能对来自小规模群体的学生和第一代大学生特别有价值。与此同时，以传统的以学徒为基础的实验室研究的形式获得本科生研究经验的机会历来有利于多数群体的学生。治疗已被证明提供了与传统研究体验相同的一些好处，但规模要大得多，成本更低，所需时间更短。该项目将通过降低实施治疗的障碍，为生物化学研究提供广泛的边做边学的途径。该项目旨在评估以前开发的生物化学疗法--生物化学可信科学研究实验室(BASIL)的参与情况。该项目将与机构的教职员工接触，这些机构的学生将从更多获得研究经验的机会中受益最大，重点是为少数族裔服务的机构。罗勒疗法在十个校园全面实施。超过25个其他校区正在通过先前的工作探索和/或使用课程的部分内容。该项目将在未来5年通过一系列招聘和培训研讨会以及精心设计的指导计划，为该项目再增加50个校区。该项目将侧重于为少数民族服务的机构，历史上的黑人学院和大学、部落学院和社区学院。该项目的目标是调查采用、实施和维持CURE的过程，有三个具体目标：目标1.确定对CURE实施和跨机构类型的可持续性的支持和障碍；目标2.描述机构背景和不同机构类型的CURE实施差异之间的关系；以及目标3.通过师资发展促进不同背景下的实施和可持续性。该项目将通过管理和收集(A)聘用前调查、(B)实施计划、(C)实施调查和(D)半结构化访谈，从参与的教职员工那里收集数据。该项目将与现场其他已建立的CURE社区合作，评估CURE实施过程中是否存在任何障碍，如成本、机构支持或教师工作量的影响。该项目还将根据人口统计数据、规模、位置和其他因素评估CURE战略在参与校园中的可持续性。作为这一实施和评估过程的结果，该项目寻求为加强科学、技术和医学领域的多样化劳动力做出贡献。NSF IUSE：EHR计划支持研究和开发项目，以提高所有学生的STEM教育的有效性。通过参与的学生学习路径，该计划支持有前景的实践和工具的创建、探索和实施。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Abstract 2052: Exploring Experimental PDB Structures and Computed Structure Models from Artificial Intelligence/Machine Learning at RCSB Protein Data Bank (RCSB.org)

摘要 2052：在 RCSB 蛋白质数据库 (RCSB.org) 中探索来自人工智能/机器学习的实验 PDB 结构和计算结构模型

• DOI: 10.1016/j.jbc.2023.103434
• 发表时间: 2023
• 期刊: Journal of Biological Chemistry
• 影响因子: 4.8
• 作者: Zardecki, Christine;Craig, Paul;Burley, Stephen
• 通讯作者: Burley, Stephen

Identifying esterase and lipase activity in proteins of unknown function

鉴定未知功能蛋白质中的酯酶和脂肪酶活性

• DOI: 10.1016/j.bpj.2022.11.2580
• 发表时间: 2023
• 期刊: Biophysical Journal
• 影响因子: 3.4
• 作者: Koeppe, Julia R.;Serrano, Christopher;Thompson, Sylvia;Holliday, Gregg;Singh, Veronica;Cup, Theodore
• 通讯作者: Cup, Theodore

Using structure to predict function in protein biochemistry: a combined computational and wet lab approach

使用结构预测蛋白质生物化学中的功能：计算和湿实验室相结合的方法

• DOI: 10.1016/j.bpj.2021.11.2877
• 发表时间: 2022
• 期刊: Biophysical Journal
• 影响因子: 3.4
• 作者: Koeppe, Julia R.;Craig, Paul A.
• 通讯作者: Craig, Paul A.

The BASIL cure: Using structure to predict function in protein biochemistry

BASIL 疗法：利用结构预测蛋白质生物化学中的功能

• DOI: 10.1016/j.bpj.2022.11.1681
• 发表时间: 2023
• 期刊: Biophysical Journal
• 影响因子: 3.4
• 作者: Koeppe, Julia R.;Roberts, Rebecca;Hall, Bonnie L.;Craig, Paul A.
• 通讯作者: Craig, Paul A.

Abstract 2096: Biochemical characterization of protein 3r8e as a novel glucose kinase

摘要 2096：蛋白质 3r8e 作为新型葡萄糖激酶的生化表征

• DOI: 10.1016/j.jbc.2023.103634
• 发表时间: 2023
• 期刊: Journal of Biological Chemistry
• 影响因子: 4.8
• 作者: Dencklau, Dalton;Evertsen, Michel;Hall, Bonnie
• 通讯作者: Hall, Bonnie