CAREER: Neurodevelopmental Mechanisms of Stressor Controllability and Resilience

职业：压力源可控性和弹性的神经发育机制

• 批准号: 2145372
• 负责人: Dylan Gee
• 金额: $ 72.07万
• 依托单位: Yale University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2145372&HistoricalAwards=false
• 关键词: CAREER; Neurodevelopmental; Mechanisms; Stressor; Controllability

Stress is a universal human experience that can have consequences for mental and physical health. Stress often increases during adolescence, and the developing brain is particularly sensitive to stress during this phase of life. Across cultures and centuries, adolescence has been noted as a time of dramatic changes in the body, brain, and behavior. During this time, youth are at heightened risk for a number of neuropsychiatric disorders, including anxiety and mood disorders, psychosis, eating disorders, personality disorders, and substance use disorders. Recent work has begun to reveal unique facets of the adolescent brain that may help us to understand how it develops and responds to stress and, concomitantly, how to better support youth during this challenging time period in their lives. This project will examine how experiences shape brain development and the capacity to cope with stress, which is essential for advancing knowledge about how to optimize well-being. While adolescence is most commonly studied as a period of heightened risk, the current study will leverage knowledge about the unique nature of the adolescent brain with the goal to promote resilience. A better understanding of how the adolescent brain responds to stress will have broad implications for child and adolescent well-being, parenting, educational settings, and public policy. The broader impacts of this project include extensive mentorship and outreach activities, which will broaden inclusion in developmental neuroscience and provide opportunities for students to engage deeply with the science of stress and adolescent brain development, while also educating the general public about the varieties and effects of stress on their lives.Although stress can be challenging, recent research has shown that not all stress has negative effects. Building upon evidence that experiencing controllable stress can promote resilience in adults, this project focuses on adolescence as a unique period of brain development when the controllability of a stressor may be particularly beneficial for promoting resilience. Using behavioral, physiological, and neuroimaging approaches, this project will investigate age-related differences in the effects of stressor controllability and mechanistic pathways linking controllable stress to adaptive coping. Researchers will utilize behavioral tasks paired with functional magnetic resonance imaging (fMRI) to study how experience with controllable stress alters the developing brain. The researchers hypothesize that two varieties of stress, controllable and uncontrollable, will have differing effects on the connectivity between brain areas needed for emotional regulation and decision-making, causing better or worse responses to later stressors in both the lab and the real world. Through a set of behavioral tasks designed to expose adolescents to both forms of stress and contrast them, they hope to gain a better understanding of the underlying neural mechanisms and the efficacy of controllable stress as a helpful intervention. Specifically, Aim 1 will examine how the experience of having control over a stressor can influence responses to later uncontrollable stress, via modulation of brain circuitry involved in motivated behavior. Aim 2 will examine how controllable stress (relative to uncontrollable or no stress) influences inferences about environmental controllability. Aim 3 will test the extent to which the effects of controllable stress generalize to real-world settings and promote adaptive coping behaviors in daily life. This research will inform critical questions about neuroplasticity and how stress “gets under the skin” to shape long-term neurobehavioral outcomes, as well as when and how interventions may be most effective for promoting resilience in the face of stress.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

压力是一种普遍的人类体验，可能对身心健康产生影响。压力通常在青春期增加，发育中的大脑在这个阶段对压力特别敏感。在不同的文化和世纪中，青春期被认为是身体、大脑和行为发生巨大变化的时期。在此期间，青年人患上一些神经精神疾病的风险更高，包括焦虑和情绪障碍、精神病、饮食失调、人格障碍和药物使用障碍。最近的工作已经开始揭示青少年大脑的独特方面，这可能有助于我们了解它是如何发展和应对压力的，以及如何更好地支持青少年在这个充满挑战的时期。该项目将研究经验如何塑造大脑发育和科普压力的能力，这对于推进有关如何优化福祉的知识至关重要。虽然青春期通常被认为是一个风险较高的时期，但目前的研究将利用有关青少年大脑独特性质的知识，以促进恢复力。更好地了解青少年大脑如何应对压力将对儿童和青少年的健康，育儿，教育环境和公共政策产生广泛的影响。该项目的更广泛影响包括广泛的指导和外展活动，这将扩大发展神经科学的包容性，并为学生提供深入参与压力和青少年大脑发育科学的机会，同时也教育公众了解压力的种类和对他们生活的影响。虽然压力可能具有挑战性，但最近的研究表明，并非所有压力都有负面影响。基于经历可控压力可以促进成年人恢复力的证据，该项目将重点放在青春期作为大脑发育的独特时期，此时压力源的可控性可能对促进恢复力特别有益。使用行为，生理和神经影像学的方法，这个项目将调查与年龄相关的差异的影响，压力可控性和机械途径连接可控的压力适应性应对。研究人员将利用行为任务与功能性磁共振成像（fMRI）来研究可控压力的经历如何改变发育中的大脑。研究人员假设，两种压力，可控和不可控，将对情绪调节和决策所需的大脑区域之间的连接产生不同的影响，从而导致实验室和真实的世界中对后期压力源的反应更好或更差。通过一组旨在使青少年暴露于两种形式的压力并将其进行对比的行为任务，他们希望更好地了解潜在的神经机制以及可控压力作为一种有益干预的功效。具体来说，目标1将研究如何控制压力源的经验可以影响对后来无法控制的压力的反应，通过调制参与动机行为的大脑回路。目标2将考察可控压力（相对于不可控或无压力）如何影响关于环境可控性的推断。目标3将测试可控压力的影响在多大程度上推广到现实世界的设置，并促进日常生活中的适应性应对行为。这项研究将为神经可塑性和压力如何“进入皮肤下”塑造长期神经行为结果的关键问题提供信息，以及何时以及如何干预可能最有效地促进面对压力时的恢复力。该奖项反映了NSF的法定使命，并被认为值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估来支持。

项目成果

Development and validation of the Dimensional Inventory of Stress and Trauma Across the Lifespan (DISTAL): A novel assessment tool to facilitate the dimensional study of psychobiological sequelae of exposure to adversity

生命周期压力和创伤维度清单（DISTAL）的开发和验证：一种新颖的评估工具，促进逆境心理生物学后遗症的维度研究

• DOI: 10.1002/dev.22372
• 发表时间: 2023
• 期刊: Developmental Psychobiology
• 影响因子: 2.2
• 作者: Cohodes, Emily M.;McCauley, Sarah;Pierre, Jasmyne C.;Hodges, H. R.;Haberman, Jason T.;Santiuste, Isabel;Rogers, Marisa K.;Wang, Jenny;Mandell, Jeffrey D.;Gee, Dylan G.
• 通讯作者: Gee, Dylan G.

Neurodevelopmental mechanisms linking early experiences and mental health: Translating science to promote well-being among youth.

• DOI: 10.1037/amp0001107
• 发表时间: 2022-12
• 期刊: AMERICAN PSYCHOLOGIST
• 影响因子: 16.4
• 作者: Gee, Dylan G

Managing fear and anxiety in development: A framework for understanding the neurodevelopment of emotion regulation capacity and tendency

• DOI: 10.1016/j.neubiorev.2022.105002
• 发表时间: 2022-12-23
• 期刊: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
• 影响因子: 8.2
• 作者: Caballero, Camila;Nook, Erik C.;Gee, Dylan G.
• 通讯作者: Gee, Dylan G.

Characterizing the dimensional structure of early-life adversity in the Adolescent Brain Cognitive Development (ABCD) Study.

• DOI: 10.1016/j.dcn.2023.101256
• 发表时间: 2023-06
• 期刊: DEVELOPMENTAL COGNITIVE NEUROSCIENCE
• 影响因子: 4.7
• 作者: Brieant, Alexis;Vannucci, Anna;Nakua, Hajer;Harris, Jenny;Lovell, Jack;Brundavanam, Divya;Tottenham, Nim;Gee, Dylan G.
• 通讯作者: Gee, Dylan G.