CAREER: Neurodevelopmental Mechanisms of Stressor Controllability and Resilience

职业：压力源可控性和弹性的神经发育机制

• 批准号: 2145372
• 负责人: Dylan Gee
• 金额: $ 72.07万
• 依托单位: Yale University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2145372&HistoricalAwards=false
• 关键词: CAREER; Neurodevelopmental; Mechanisms; Stressor; Controllability

Stress is a universal human experience that can have consequences for mental and physical health. Stress often increases during adolescence, and the developing brain is particularly sensitive to stress during this phase of life. Across cultures and centuries, adolescence has been noted as a time of dramatic changes in the body, brain, and behavior. During this time, youth are at heightened risk for a number of neuropsychiatric disorders, including anxiety and mood disorders, psychosis, eating disorders, personality disorders, and substance use disorders. Recent work has begun to reveal unique facets of the adolescent brain that may help us to understand how it develops and responds to stress and, concomitantly, how to better support youth during this challenging time period in their lives. This project will examine how experiences shape brain development and the capacity to cope with stress, which is essential for advancing knowledge about how to optimize well-being. While adolescence is most commonly studied as a period of heightened risk, the current study will leverage knowledge about the unique nature of the adolescent brain with the goal to promote resilience. A better understanding of how the adolescent brain responds to stress will have broad implications for child and adolescent well-being, parenting, educational settings, and public policy. The broader impacts of this project include extensive mentorship and outreach activities, which will broaden inclusion in developmental neuroscience and provide opportunities for students to engage deeply with the science of stress and adolescent brain development, while also educating the general public about the varieties and effects of stress on their lives.Although stress can be challenging, recent research has shown that not all stress has negative effects. Building upon evidence that experiencing controllable stress can promote resilience in adults, this project focuses on adolescence as a unique period of brain development when the controllability of a stressor may be particularly beneficial for promoting resilience. Using behavioral, physiological, and neuroimaging approaches, this project will investigate age-related differences in the effects of stressor controllability and mechanistic pathways linking controllable stress to adaptive coping. Researchers will utilize behavioral tasks paired with functional magnetic resonance imaging (fMRI) to study how experience with controllable stress alters the developing brain. The researchers hypothesize that two varieties of stress, controllable and uncontrollable, will have differing effects on the connectivity between brain areas needed for emotional regulation and decision-making, causing better or worse responses to later stressors in both the lab and the real world. Through a set of behavioral tasks designed to expose adolescents to both forms of stress and contrast them, they hope to gain a better understanding of the underlying neural mechanisms and the efficacy of controllable stress as a helpful intervention. Specifically, Aim 1 will examine how the experience of having control over a stressor can influence responses to later uncontrollable stress, via modulation of brain circuitry involved in motivated behavior. Aim 2 will examine how controllable stress (relative to uncontrollable or no stress) influences inferences about environmental controllability. Aim 3 will test the extent to which the effects of controllable stress generalize to real-world settings and promote adaptive coping behaviors in daily life. This research will inform critical questions about neuroplasticity and how stress “gets under the skin” to shape long-term neurobehavioral outcomes, as well as when and how interventions may be most effective for promoting resilience in the face of stress.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

压力是一种普遍的人类体验，可能会对身心健康产生影响。在青少年期间，压力通常会增加，而发展中的大脑在生活阶段对压力特别敏感。在整个文化和几个世纪以来，青少年被认为是身体，大脑和行为发生巨大变化的时代。在这段时间里，青年人患有许多神经精神疾病的风险，包括焦虑和情绪障碍，精神病，饮食失调，人格障碍和药物使用障碍。最近的工作已经开始揭示青少年大脑的独特方面，这可能有助于我们了解其如何发展和应对压力，并同时在生活中的这个挑战时期如何更好地支持青年。该项目将研究体验如何塑造大脑发育和应对压力的能力，这对于促进有关如何优化的知识至关重要，而在青少年敏感的情况下，最常见的是作为一个高风险时期的研究，当前的研究将利用有关青少年大脑的独特性质的知识，以促进弹性。更好地了解青少年大脑对压力的反应将对儿童和青少年的幸福感，育儿，教育环境和公共政策产生广泛的影响。该项目的更广泛的影响包括广泛的心态和外展活动，这将扩大纳入发展性神经科学的包容性，并为学生提供了与压力和青少年大脑发展科学深入参与的机会，同时还可以教育公众对压力的变化和压力对生活压力的变化和影响。最新的研究表明，所有压力都没有影响所有压力。基于证据表明，控制压力的经验可以促进成人的韧性，该项目将重点放在青少年作为大脑发育的独特时期，而压力源的可控性可能对促进弹性特别有益。使用行为，生理和神经影像学方法，该项目将研究与年龄相关的压力可控性和机械途径的影响，将受控应力与适应性应对联系起来。研究人员将利用与功能性磁共振成像（fMRI）配对的行为任务来研究受控应力的经验如何改变发育中的大脑。研究人员假设，受控和无法控制的压力的两种变化将对情绪调节和决策所需的大脑领域之间的连通性产生不同的影响，从而对实验室和现实世界中后来的压力源产生更好或更差的反应。通过一系列旨在使青少年承受两种形式的压力并对比的行为任务，他们希望更好地了解潜在的神经机制以及控制压力作为有益的干预措施的有效性。具体而言，AIM 1将研究控制压力源的经验如何通过调节涉及动机行为的脑电路来影响对后来无法控制的压力的反应。 AIM 2将检查控制应力（相对于不可控制或没有压力）如何影响对环境可控性的推论。 AIM 3将测试受控压力的影响推广到现实环境的程度，并促进日常生活中的适应性应对行为。这项研究将为有关神经塑性的关键问题以及如何“在皮肤下”塑造长期神经行为成果，以及何时以及如何在压力面对促进弹性方面最有效的干预措施。这一奖项反映了NSF的法定任务，这反映了通过基金会的智力效果和广泛的评估，这反映了NSF的法定任务，并具有值得通过评估的评估。

项目成果

Development and validation of the Dimensional Inventory of Stress and Trauma Across the Lifespan (DISTAL): A novel assessment tool to facilitate the dimensional study of psychobiological sequelae of exposure to adversity

生命周期压力和创伤维度清单（DISTAL）的开发和验证：一种新颖的评估工具，促进逆境心理生物学后遗症的维度研究

• DOI: 10.1002/dev.22372
• 发表时间: 2023
• 期刊: Developmental Psychobiology
• 影响因子: 2.2
• 作者: Cohodes, Emily M.;McCauley, Sarah;Pierre, Jasmyne C.;Hodges, H. R.;Haberman, Jason T.;Santiuste, Isabel;Rogers, Marisa K.;Wang, Jenny;Mandell, Jeffrey D.;Gee, Dylan G.
• 通讯作者: Gee, Dylan G.

Neurodevelopmental mechanisms linking early experiences and mental health: Translating science to promote well-being among youth.

• DOI: 10.1037/amp0001107
• 发表时间: 2022-12
• 期刊: AMERICAN PSYCHOLOGIST
• 影响因子: 16.4
• 作者: Gee, Dylan G

Characterizing the dimensional structure of early-life adversity in the Adolescent Brain Cognitive Development (ABCD) Study.

• DOI: 10.1016/j.dcn.2023.101256
• 发表时间: 2023-06
• 期刊: DEVELOPMENTAL COGNITIVE NEUROSCIENCE
• 影响因子: 4.7
• 作者: Brieant, Alexis;Vannucci, Anna;Nakua, Hajer;Harris, Jenny;Lovell, Jack;Brundavanam, Divya;Tottenham, Nim;Gee, Dylan G.
• 通讯作者: Gee, Dylan G.

Managing fear and anxiety in development: A framework for understanding the neurodevelopment of emotion regulation capacity and tendency

• DOI: 10.1016/j.neubiorev.2022.105002
• 发表时间: 2022-12-23
• 期刊: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
• 影响因子: 8.2
• 作者: Caballero, Camila;Nook, Erik C.;Gee, Dylan G.
• 通讯作者: Gee, Dylan G.