BIORETS: Translating Authentic Microbial Evolution and Big Data Research to the Classroom
BIORETS:将真实的微生物进化和大数据研究转化为课堂
基本信息
- 批准号:2147075
- 负责人:
- 金额:$ 59.99万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-03-01 至 2025-02-28
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
This integrated research-education program will engage 24 high school and middle school science teachers over 3 years in authentic microbiology research to understand how bacteria adaptively evolve when producing biofilm. This research training will prepare them to lead a similar experiment in their classrooms, where students will observe and study bacteria evolving in biofilms over a week using an innovative curriculum. Both research and teaching will be supported by mentors in our laboratory and in their classrooms, where most students come from underrepresented backgrounds. We will measure whether our program improves teacher confidence in using life science experiments in their classrooms, as well as student learning of key life science topics that are essential to careers in biotechnology. This program will empower greater understanding by teachers and students of how microbes evolve, a crucial topic today. The dynamics of adaptive evolution in microbial biofilms are broadly significant and poorly understood. Perhaps the greatest mystery – why is adaptation so fast? – provides the key advantage of our integrated research-education program. Researchers aged 12+ conduct evolution experiments with safe Pseudomonas bacteria to observe and study the processes of adaptation and ecological diversification within one week. Fitter mutants often produce unique colony morphologies caused by a single mutation. Yet it remains unknown why certain traits are selected so rapidly. Teachers will conduct experiments to study this problem with mentorship from a postdoctoral scholar, a PhD student, and 4 teacher-mentors experienced in our EvolvingSTEM laboratory curriculum. Teachers will test i) how adaptive phenotypes alter biofilm demography and subsequent evolution and, ii) how altered surface-sensing influences evolutionary dynamics. These experiments will advance understanding of Pseudomonas population biology. Following their summer program, teachers will incorporate these research questions in an established, effective classroom curriculum already in diverse schools. Teachers will be supported by our research team, curriculum coordinators, and community partners. We will assess whether our program improves teacher and student attitudes towards and knowledge of core life science topics and their relevance to applications in medicine and applied sciences. We predict teachers will gain confidence in conducting authentic experimentation and data analysis in their classrooms, which will empower their predominantly URM students to develop these same skills. The focus on evolution as a foundational concept is especially relevant today and will remedy common misconceptions stemming from a lack of active learning opportunity.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
这个综合研究教育计划将在3年内让24名高中和中学科学教师参与真实的微生物学研究,以了解细菌在产生生物膜时如何适应性进化。这项研究培训将帮助他们在课堂上进行类似的实验,学生将使用创新课程观察和研究细菌在生物膜中进化一周。研究和教学都将得到我们实验室和教室里的导师的支持,大多数学生来自代表性不足的背景。我们将衡量我们的计划是否提高了教师在课堂上使用生命科学实验的信心,以及学生学习对生物技术职业至关重要的关键生命科学主题。该计划将使教师和学生更好地了解微生物如何进化,这是当今的一个关键话题。微生物生物膜中的适应性进化动力学具有广泛的意义,但知之甚少。也许最大的谜团-为什么适应如此之快?- 提供了我们的综合研究教育计划的关键优势。12岁以上的研究人员在一周内用安全的假单胞菌进行进化实验,观察和研究适应和生态多样化的过程。适应性突变体通常产生由单一突变引起的独特的菌落形态。然而,为什么某些特征被如此迅速地选择仍然是未知的。教师将在一名博士后学者、一名博士生和4名在我们的EvolvingSTEM实验室课程中经验丰富的导师的指导下进行实验来研究这个问题。教师将测试i)适应性表型如何改变生物膜人口统计学和随后的进化,ii)改变表面传感如何影响进化动力学。这些实验将促进对假单胞菌种群生物学的理解。在他们的暑期课程之后,教师们将把这些研究问题纳入已经在不同学校建立的有效的课堂课程中。教师将得到我们的研究团队,课程协调员和社区合作伙伴的支持。我们将评估我们的计划是否提高了教师和学生对核心生命科学主题的态度和知识,以及它们与医学和应用科学应用的相关性。我们预测教师将在课堂上进行真实的实验和数据分析时获得信心,这将使他们主要的URM学生能够发展这些相同的技能。将进化作为一个基本概念的关注在今天尤其重要,并将纠正由于缺乏主动学习机会而产生的常见误解。该奖项反映了NSF的法定使命,并被认为值得通过使用基金会的知识价值和更广泛的影响审查标准进行评估来支持。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Vaughn Cooper其他文献
EXCESS DIETARY SUGAR ALTERS COLONOCYTE METABOLISM AND IMPAIRS THE EARLY PROLIFERATIVE RESPONSE TO DAMAGE
- DOI:
10.1053/j.gastro.2023.03.113 - 发表时间:
2023-04-01 - 期刊:
- 影响因子:
- 作者:
Ansen Burr;Junyi Ji;Kadir Ozler;Heather Mentrup;Onur Eskiocak;Rachel Cumberland;Ashley Menk;Xiaoyi Zhang;Abigail Overacre-Delgoffe;Natalie Rittenhouse;Chris Marshall;Vaughn Cooper;Amanda Poholek;Greg Delgoffe;Semir Beyaz;Timothy Hand - 通讯作者:
Timothy Hand
Vaughn Cooper的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Vaughn Cooper', 18)}}的其他基金
Collaborative Proposal: Role of tRNA base modifications in genetic code accuracy and bacterial fitness
合作提案:tRNA 碱基修饰在遗传密码准确性和细菌适应性中的作用
- 批准号:
1818245 - 财政年份:2018
- 资助金额:
$ 59.99万 - 项目类别:
Standard Grant
Collaborative Research: Understanding the basis of interactions between adaptive mutations and their environment
合作研究:了解适应性突变与其环境之间相互作用的基础
- 批准号:
0844157 - 财政年份:2009
- 资助金额:
$ 59.99万 - 项目类别:
Standard Grant
CAREER: Quantifying pleiotropy by parallel experimental evolution
职业:通过平行实验进化量化多效性
- 批准号:
0845851 - 财政年份:2009
- 资助金额:
$ 59.99万 - 项目类别:
Standard Grant
相似海外基金
NSF Convergence Accelerator track L: Translating insect olfaction principles into practical and robust chemical sensing platforms
NSF 融合加速器轨道 L:将昆虫嗅觉原理转化为实用且强大的化学传感平台
- 批准号:
2344284 - 财政年份:2024
- 资助金额:
$ 59.99万 - 项目类别:
Standard Grant
Conference: Translating Molecular Science Innovations into Biotechnology Solutions
会议:将分子科学创新转化为生物技术解决方案
- 批准号:
2419731 - 财政年份:2024
- 资助金额:
$ 59.99万 - 项目类别:
Standard Grant
ART: Translating Research to Practice to Create Climate-Ready Communities Across Virginia
ART:将研究转化为实践,在弗吉尼亚州创建气候就绪型社区
- 批准号:
2331271 - 财政年份:2024
- 资助金额:
$ 59.99万 - 项目类别:
Cooperative Agreement
ART: American University Translating Research into Action Center (TRAC)
ART:美国大学将研究转化为行动中心 (TRAC)
- 批准号:
2331399 - 财政年份:2024
- 资助金额:
$ 59.99万 - 项目类别:
Cooperative Agreement
ART: Translating Engineering Driven Health Initiatives From Idea to Impact
ART:将工程驱动的健康举措从理念转化为影响
- 批准号:
2331440 - 财政年份:2024
- 资助金额:
$ 59.99万 - 项目类别:
Cooperative Agreement
Global Bible: British and German Bible Societies Translating Colonialism, 1800-1914.
全球圣经:英国和德国圣经公会翻译殖民主义,1800-1914 年。
- 批准号:
AH/X001881/1 - 财政年份:2023
- 资助金额:
$ 59.99万 - 项目类别:
Research Grant
(MIS)TRANSLATING DECEIT: DISINFORMATION AS A TRANSLINGUAL, DISCURSIVE DYNAMIC
(错误)翻译欺骗:作为跨语言、话语动态的虚假信息
- 批准号:
AH/X010007/1 - 财政年份:2023
- 资助金额:
$ 59.99万 - 项目类别:
Research Grant
Computational comparative anatomy: Translating between species in neuroscience
计算比较解剖学:神经科学中物种之间的翻译
- 批准号:
BB/X013227/1 - 财政年份:2023
- 资助金额:
$ 59.99万 - 项目类别:
Research Grant
Translating an MR-guided focused ultrasound system for first-in-human precision neuromodulation of pain circuits
将 MR 引导聚焦超声系统用于人体首个疼痛回路精确神经调节
- 批准号:
10805159 - 财政年份:2023
- 资助金额:
$ 59.99万 - 项目类别:
30 years of Developing and Translating Neural Therapies for Repair
神经修复疗法的开发和转化 30 年
- 批准号:
10683633 - 财政年份:2023
- 资助金额:
$ 59.99万 - 项目类别: