Doctoral Dissertation Research: Influences of Physiological Stress on Microbiome, Metabolism, and Health in Nurses

博士论文研究：生理压力对护士微生物组、代谢和健康的影响

• 批准号: 2147647
• 负责人: Theodore Schurr
• 金额: $ 3.25万
• 依托单位: University of Pennsylvania
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2147647&HistoricalAwards=false
• 关键词: Doctoral; Dissertation; Research; Influences; Physiological

The gut microbiome, or the community of microorganisms residing in the human digestive tract, is affected by stressful conditions and can influence cardiometabolic health. This research project investigates the ways in which human-microbiome-health interactions are sensitive to different work conditions through focusing on nurses, frontline workers who experience the metabolic and energetic stress of prolonged shift work conditions. This project seeks to understand the health risk factors associated with frontline labor and results may inform nursing practices. Individual personal health information are shared directly with nurse participants, and results are shared with Nurse Scientists and leaders at the project’s hospital research site, empowering this site to potentially offer better health outcomes for nurses. This project also creates cross-disciplinary training, data-sharing, and publishing opportunities for undergraduate students, nurse scientists, nursing leaders, and nurse participants. Most project collaborators are scholars from groups historically underrepresented in STEM research. Nursing is commonly associated with extremely stressful conditions and poor cardiometabolic health outcomes, including coronary heart disease (CHD), metabolic disorders, obesity, and gastrointestinal complaints, especially in rotational/night shifts and in high stress hospital environments. This project compares biomarker and survey data from a cohort of nurses as they engage in differing types of shift work. Using a cross-sectional sample survey of nurses, the investigators measure both shift and non-shift nurses’ indicators of microbial diversity/composition, inflammation, intestinal permeability, and metabolism. Survey data are used to record diet, activity level, socioeconomic status, demographics, and shift-work conditions to assess how these factors may mediate metabolic and microbial outcomes. Biological samples and questionnaires are collected from a focused group who have not engaged in rotating shift work in over a year, starting in their first month of shiftwork, followed by monthly sampling for four months. It is predicted that gut microbiome composition among shift work and non-shift work nurses will differentiate as nurses begin shiftwork. Ultimately, the results of this project aim to illuminate one of the ways in which frontline shift labor may become embodied.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

肠道微生物组，或居住在人类消化道的微生物群落，会受到压力条件的影响，并可能影响心脏代谢健康。本研究项目通过关注护士、一线工作人员在长时间轮班工作条件下经历代谢和能量压力，调查了人类-微生物-健康相互作用对不同工作条件的敏感方式。该项目旨在了解与一线劳动相关的健康风险因素，结果可能为护理实践提供信息。个人健康信息直接与护士参与者共享，结果与项目医院研究站点的护士科学家和领导者共享，使该站点能够为护士提供更好的健康结果。该项目还为本科生、护士科学家、护理领导者和护士参与者创造了跨学科培训、数据共享和出版的机会。大多数项目合作者都是来自STEM研究中历史上代表性不足的群体的学者。护理通常与极度紧张的状况和不良的心脏代谢健康结果相关，包括冠心病（CHD）、代谢紊乱、肥胖和胃肠道疾病，特别是在轮班/夜班和高压力的医院环境中。该项目比较了一组从事不同类型轮班工作的护士的生物标志物和调查数据。通过对护士进行横断面抽样调查，研究人员测量了轮班护士和非轮班护士的微生物多样性/组成、炎症、肠道通透性和代谢指标。调查数据用于记录饮食、活动水平、社会经济地位、人口统计和轮班条件，以评估这些因素如何介导代谢和微生物结果。生物样本和调查问卷是从一年以上没有轮班工作的重点人群中收集的，从他们轮班工作的第一个月开始，然后每月抽样四个月。据预测，轮班工作和非轮班工作的护士肠道微生物组成将区分护士开始轮班工作。最终，这个项目的结果旨在阐明一线轮班劳动可能具体化的一种方式。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。