REU Site: Genetic and Biochemical Analysis of Proteins

REU 网站：蛋白质的遗传和生化分析

• 批准号: 2150331
• 负责人: James Forney
• 金额: $ 26.39万
• 依托单位: Purdue University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2150331&HistoricalAwards=false
• 关键词: REU; Site; Genetic; Biochemical; Analysis

This REU Site award to Purdue University, located in West Lafayette, Indiana, will support the training of eight students for ten weeks during the summers of 2022-2024. It is anticipated that a total of 24 students, primarily from schools with limited research opportunities or from an underrepresented group, will be trained in the program. Participants will be recruited from life science and chemistry majors who have an interest in research. Students will develop the knowledge and problem-solving skills required for careers in life sciences research. The program will contribute to increasing the preparation and diversity of the nation’s science and technology workforce. Students will learn how research is conducted, and many will present the results of their work at scientific conferences. The web-based SALG URSSA assessment tool will be used to determine the effectiveness of the training program. Students will be tracked after the program in order to determine their career paths.The primary intellectual goal of the program is to provide advanced training in the experimental analysis of protein function. A three-day orientation will introduce key concepts in protein biochemistry and experimental design. The remainder of the program will emphasize full-time research supplemented with weekly sessions on ethical conduct in research, professional communication, and applications to graduate school. Faculty mentored projects in the Department of Biochemistry include analysis of enzyme mechanisms, post-translational protein modifications, epigenetic regulation, and protein-nucleic acid interactions studied in a wide range of biological contexts including plant secondary metabolism, photosynthesis, tissue differentiation and the drosophila visual system. Many of the projects will highlight the value of genetic approaches to study protein function. Participants will present their results at a university-wide poster session at the end of the program. Complete applications will include academic transcripts, two letters of recommendation and a personal statement. More information about the program is available by visiting https://ag.purdue.edu/biochem/Pages/REU.aspx, or by contacting the PI (Dr. James Forney at [e-mail]).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个REU网站奖给普渡大学，位于西拉斐特，印第安纳州，将支持八名学生在2022年至2024年的夏天为期十周的培训。预计共有24名学生，主要来自研究机会有限的学校或代表性不足的群体，将在该计划中接受培训。参与者将从对研究感兴趣的生命科学和化学专业的学生中招募。学生将发展生命科学研究职业所需的知识和解决问题的技能。该计划将有助于提高国家科学和技术劳动力的准备和多样性。学生将学习如何进行研究，许多人将在科学会议上展示他们的工作成果。基于网络的SALG URSSA评估工具将用于确定培训方案的有效性。课程结束后将对学生进行跟踪，以确定他们的职业道路。该课程的主要智力目标是提供蛋白质功能实验分析的高级培训。为期三天的方向将介绍蛋白质生物化学和实验设计的关键概念。该计划的其余部分将强调全日制研究，并补充每周一次的研究，专业沟通和研究生院申请中的道德行为。生物化学系的教师指导项目包括酶机制分析，翻译后蛋白质修饰，表观遗传调控以及在广泛的生物背景下研究的蛋白质-核酸相互作用，包括植物次生代谢，光合作用，组织分化和果蝇视觉系统。许多项目将突出遗传方法研究蛋白质功能的价值。参与者将在计划结束时在全校范围内的海报会议上展示他们的结果。完整的申请将包括学术成绩单，两封推荐信和一份个人陈述。有关该计划的更多信息，请访问https：//ag.purdue.edu/biochem/Pages/REU.aspx，或联系PI（James Forney博士，[e-mail]）。该奖项反映了NSF的法定使命，并被认为值得通过使用基金会的知识价值和更广泛的影响审查标准进行评估来支持。

项目成果

An expanded toolkit of drug resistance cassettes for Candida glabrata, Candida auris, and Candida albicans leads to new insights into the ergosterol pathway.

• DOI: 10.1128/msphere.00311-23
• 发表时间: 2023-12-20
• 期刊: MSPHERE
• 影响因子: 4.8
• 作者: Gregor, Justin B.;Gutierrez-Schultz, Victor A.;Hoda, Smriti;Baker, Kortany M.;Saha, Debasmita;Burghaze, Madeline G.;Vazquez, Cynthia;Burgei, Kendra E.;Briggs, Scott D.
• 通讯作者: Briggs, Scott D.