SBIR Phase I: Improved memory during sleep at home with a wearable EEG device for tailored stimulation of slow oscillations

SBIR 第一阶段：通过可穿戴脑电图设备改善在家睡眠期间的记忆力，以定制慢振荡刺激

• 批准号: 2151469
• 负责人: Jason Worchel
• 金额: $ 25.57万
• 依托单位: NEUROGENECES, INC.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2151469&HistoricalAwards=false
• 关键词: SBIR; Phase; Improved; memory; during

This Small Business Innovation Research (SBIR) Phase I project improves memory for the elderly. Memory loss is a major concern of an aging population. The $29 B global memory enhancement market comprises supplements, training software, and drugs, although evidence of efficacy is limited. This project will create a user-friendly sleep headband with audio stimulation to improve memory. The solution will create a new category of non-invasive medical devices to benefit people in clinical, home, and professional settings. This Small Business Innovation Research (SBIR) Phase I project demonstrates the feasibility of a wireless electroencephalogram (EEG) headband that increases memory consolidation during slow-wave sleep activity at home. Audio stimulation during slow-wave sleep activity using polysomnogram equipment has been previously demonstrated to enhance memory retention by facilitating memory consolidation. The envisioned headband acquires high quality EEG data to sense slow-wave brain wave activity and provide synchronous audio stimulation. The anticipated project outcomes are: a) a wireless sleep headband designed for comfort and usability, b) demonstration of enhanced slow-wave brain activity during sleep, and c) evidence of meaningful improvements to memory retention measured by standard clinical assessments.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个小企业创新研究（SBIR）第一阶段项目改善老年人的记忆力。 记忆丧失是老龄化人口的主要问题。价值290 B美元的全球记忆增强市场包括补充剂、训练软件和药物，尽管有效性的证据有限。这个项目将创建一个用户友好的睡眠头带与音频刺激，以提高记忆力。该解决方案将创造一种新的非侵入性医疗设备类别，使临床、家庭和专业环境中的人们受益。这个小型企业创新研究（SBIR）第一阶段项目证明了无线脑电图（EEG）头带的可行性，该头带可在家中的慢波睡眠活动期间增加记忆巩固。在慢波睡眠活动期间使用多导睡眠图设备的音频刺激先前已被证明通过促进记忆巩固来增强记忆保持。所设想的头带获取高质量的EEG数据，以感测慢波脑波活动并提供同步音频刺激。预期的项目成果是：a）一个舒适和可用性设计的无线睡眠头带，B）在睡眠期间增强慢波大脑活动的演示，和c）通过标准临床评估测量的记忆保持有意义的改善证据。该奖项反映了NSF的法定使命，并已被认为是值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估的支持。