Are Stereoelectronic Effects Additive or Cooperative? (A09)

立体电子效应在自然界中非常丰富，也是有机化学中的关键因素。该项目的目标是探索立体电子效应是相加的还是合作的。为此，将研究由具有确定构型的CHF-实体构建的各种多邻位氟化烷烃。这些很少探索的功能最终将被纳入催化和生物有趣的化合物。该项目的实现需要在SFB框架内采用多学科方法：合成和结构分析将挑战WWU明斯特的分析机构，计算化学也将用于理解和量化所述相互作用。最后，这些新化合物将被应用于对映选择性催化。

Stereoelectronic effects are abundant in nature and are also key elements in organic chemistry. The goal of the project is to explore whether stereoelectronic effects are additive or cooperative. To this end, various multi-vicinal fluorinated alkanes which are constructed from CHF-entities with defined configuration will be studied. These little explored functionalities will eventually be incorporated into catalytically and biologically interesting compounds. Realization of this project demands for a multidisciplinary approach within the frame of the SFB: syntheses and structural analysis will challenge the analytical institutions of the WWU Münster and also computational chemistry will be used to understand and quantify the addressed interactions. Finally, the novel compounds will be applied to enantioselective catalysis.