Are Stereoelectronic Effects Additive or Cooperative? (A09)

立体电子效应是累加效应还是协同效应？

• 批准号: 251207433
• 金额: --
• 依托单位: Organisch-Chemisches Institut
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/251207433?language=en
• 关键词: Stereoelectronic; Effects; Additive; Cooperative; A09

Stereoelectronic effects are abundant in nature and are also key elements in organic chemistry. The goal of the project is to explore whether stereoelectronic effects are additive or cooperative. To this end, various multi-vicinal fluorinated alkanes which are constructed from CHF-entities with defined configuration will be studied. These little explored functionalities will eventually be incorporated into catalytically and biologically interesting compounds. Realization of this project demands for a multidisciplinary approach within the frame of the SFB: syntheses and structural analysis will challenge the analytical institutions of the WWU Münster and also computational chemistry will be used to understand and quantify the addressed interactions. Finally, the novel compounds will be applied to enantioselective catalysis.

立体电子效应在自然界中十分丰富，也是有机化学的重要组成部分。该项目的目标是探索立体电子效应是相加的还是协同的。为此，将研究由具有确定构型的chf实体构成的各种多邻氟化烷烃。这些很少被探索的功能最终将被纳入催化和生物学上有趣的化合物中。该项目的实现需要在SFB框架内采用多学科方法：合成和结构分析将挑战世界海洋大学<s:1>国家化学研究所的分析机构，并且计算化学将用于理解和量化所处理的相互作用。最后，新化合物将应用于对映选择性催化。