Development and Characterization of femto Electrospray Ionization

毫微微电喷雾电离的开发和表征

基本信息

  • 批准号:
    2203289
  • 负责人:
  • 金额:
    $ 42.06万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Continuing Grant
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-05-15 至 2025-04-30
  • 项目状态:
    未结题

项目摘要

With support from the Chemical Measurement and Imaging program in the National Science Foundation Division of Chemistry, and partial co-funding from the Established Program to Stimulate Competitive Research, Professor Anyin Li’s group at the University of New Hampshire (UNH) is exploring the fundamental processes underlying electrospray ionization mass spectrometry - one of the most important analytical methods used for characterization of organic, biological, and biochemical systems, including drug discovery and quality control. The methods being developed target improved analytical figures of merit, providing new opportunities to solve fundamental problems as well as to enhance UNH’s interaction with local industry and education partners. The research activities train graduate, undergraduate, and high school students, thereby increasing the talent pool for a stronger STEM workforce. K-12 science teacher participation produces contemporary science teaching materials to engage student interest. The research group is also hosting summer workshops for broad dissemination of science and technology.Existing electrospray ionization (ESI) methods have onset ionization currents on the order of nanoamps, much higher than needed by most mass analyzers. They are often plagued by non-uniform ionization efficiency, formation of nonspecific adducts, and (for small emitters) clogging. To address these issues, the Li group is advancing and characterizing ESI in the femtoamp range, with flow rates on the order of picoliters/minute. The developed methods can extend the linear dynamic range to both lower and higher concentrations, while improving spectral quality and reducing matrix interferences and variations in ionization efficiency.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
在美国国家科学基金会化学部化学测量与成像项目的支持下,以及来自刺激竞争性研究的既定项目的部分共同资助下,新罕布什尔大学(UNH)李anyin教授的团队正在探索电喷雾电离质谱法的基本过程,这是用于表征有机、生物和生化系统的最重要的分析方法之一。包括药物发现和质量控制。正在制订的方法的目标是改进有价值的分析数字,为解决基本问题以及加强联合国大学与当地工业和教育伙伴的相互作用提供新的机会。这些研究活动培训研究生、本科生和高中生,从而为更强大的STEM劳动力增加人才库。K-12科学教师参与制作当代科学教材,以吸引学生的兴趣。该研究小组还为广泛传播科学和技术举办夏季讲习班。现有的电喷雾电离(ESI)方法的起始电离电流为纳米安培数量级,远远高于大多数质谱分析仪所需的起始电离电流。它们经常受到不均匀的电离效率、非特异性加合物的形成和(小发射器)堵塞的困扰。为了解决这些问题,Li团队正在推进和表征飞安培范围内的ESI,其流量约为皮升/分钟。所开发的方法可以将线性动态范围扩展到低浓度和高浓度,同时提高光谱质量,减少基质干扰和电离效率的变化。该奖项反映了美国国家科学基金会的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Gigaohm and Teraohm Resistors in Femtoamp and Picoamp Electrospray Ionization
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Anyin Li其他文献

Measurement of the Proton Affinities of a Series of Mono- and Biradicals of Pyridine.
一系列吡啶单基和双基的质子亲和力的测量。
  • DOI:
    10.1021/jacs.0c00202
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    15
  • 作者:
    Rashmi Kumar;Guannan Li;Vanessa A. Gallardo;Anyin Li;J. Milton;John J Nash;H. Kenttämaa
  • 通讯作者:
    H. Kenttämaa

Anyin Li的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

相似海外基金

ERI: Non-Contact Ultrasound Generation and Detection for Tissue Functional Imaging and Biomechanical Characterization
ERI:用于组织功能成像和生物力学表征的非接触式超声波生成和检测
  • 批准号:
    2347575
  • 财政年份:
    2024
  • 资助金额:
    $ 42.06万
  • 项目类别:
    Standard Grant
RUI: Spectroscopic Characterization and Low Temperature Kinetic Study of Hydrogenated Aromatic Radicals
RUI:氢化芳香族自由基的光谱表征和低温动力学研究
  • 批准号:
    2348916
  • 财政年份:
    2024
  • 资助金额:
    $ 42.06万
  • 项目类别:
    Standard Grant
CAREER: atomistic characterization of protein-polymer conjugates
职业:蛋白质-聚合物缀合物的原子表征
  • 批准号:
    2339330
  • 财政年份:
    2024
  • 资助金额:
    $ 42.06万
  • 项目类别:
    Continuing Grant
A novel damage characterization technique based on adaptive deconvolution extraction algorithm of multivariate AE signals for accurate diagnosis of osteoarthritic knees
基于多变量 AE 信号自适应反卷积提取算法的新型损伤表征技术,用于准确诊断膝关节骨关节炎
  • 批准号:
    24K07389
  • 财政年份:
    2024
  • 资助金额:
    $ 42.06万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Characterization of dominant negative ACTA2 variants : a zebrafish model for non-syndromic aortic aneurysms
显性失活 ACTA2 变异的表征:非综合征性主动脉瘤的斑马鱼模型
  • 批准号:
    24K18891
  • 财政年份:
    2024
  • 资助金额:
    $ 42.06万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Characterization of the distribution and properties of inert copper in seawater
海水中惰性铜的分布和性质表征
  • 批准号:
    2343416
  • 财政年份:
    2024
  • 资助金额:
    $ 42.06万
  • 项目类别:
    Standard Grant
Collaborative Research: TRTech-PGR TRACK: Discovery and characterization of small CRISPR systems for virus-based delivery of heritable editing in plants.
合作研究:TRTech-PGR TRACK:小型 CRISPR 系统的发现和表征,用于基于病毒的植物遗传编辑传递。
  • 批准号:
    2334028
  • 财政年份:
    2024
  • 资助金额:
    $ 42.06万
  • 项目类别:
    Standard Grant
CAREER: Informed Testing — From Full-Field Characterization of Mechanically Graded Soft Materials to Student Equity in the Classroom
职业:知情测试 – 从机械分级软材料的全场表征到课堂上的学生公平
  • 批准号:
    2338371
  • 财政年份:
    2024
  • 资助金额:
    $ 42.06万
  • 项目类别:
    Standard Grant
CAREER: Advancing ceramic processing science through acoustic characterization
职业:通过声学表征推进陶瓷加工科学
  • 批准号:
    2338898
  • 财政年份:
    2024
  • 资助金额:
    $ 42.06万
  • 项目类别:
    Continuing Grant
Thermospheric Estimation and CHaracterization with Nitric Oxide (TECHNO)
使用一氧化氮进行热层估计和表征 (TECHNO)
  • 批准号:
    2343844
  • 财政年份:
    2024
  • 资助金额:
    $ 42.06万
  • 项目类别:
    Standard Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了