NSF Postdoctoral Fellowship in Biology FY 2022: Gene-Brain-Behavior Phenotypes of Dog Aggression

2022 财年 NSF 生物学博士后奖学金：狗攻击性的基因-大脑-行为表型

• 批准号: 2209046
• 负责人: Julia Espinosa Grossmann
• 金额: $ 13.8万
• 依托单位: Espinosa, Julia H
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2209046&HistoricalAwards=false
• 关键词: NSF; Postdoctoral; Fellowship; Biology; FY

This action funds an NSF Postdoctoral Research Fellowship in Biology for FY 2022, Integrative Research Investigating the Rules of Life Governing Interactions Between Genomes, Environment and Phenotypes. The fellowship supports research and training of the Fellow that will contribute to the area of Rules of Life in innovative ways. Over centuries, humans have selectively bred domestic dogs for appearance and behavioral characteristics. This practice has reduced genetic variance between breeds and resulted in a “natural experiment,” providing current researchers with a controlled opportunity for understanding the role of domestication on behavior and identifying its physiological underpinnings. Fields such as genetics and neuroscience, which have traditionally used animals such as mice and rats in controlled laboratory settings, are now looking to dogs for answers because of their long history of co-evolution with humans. By investigating the gene-brain-behavior link in dogs, who live in the same environment as humans, there is greater potential to understand how physiology and behavior are shaped by living in real-world environments. Due to very relaxed negative selection and very strong positive selection, certain traits can become common in domesticated species. The presence of these deleterious traits has been demonstrated in dog behavior and cognition using behavioral, genetic, and brain imaging. Uniting insights from these separate lines of research in a multimethod project, the Fellow will investigate gene-brain-behavior phenotypes of aggression, combining behavior assessment surveys with neuroimaging (MRI) and genetic analysis. The Fellow will investigate if systematic differences in the morphology and connectivity of aggression-related brain regions, genetic variation, and individual life histories play a role in aggressive phenotypes in dogs. An initial sample of pet dogs from the community will participate in behavior prescreening with C-BARQ (established behavior assessment instrument). Dogs that score in the top 20% and bottom 20% of aggression scales will participate in additional screening for adverse life experiences, provide cheek swabs for genotyping individuals, and be invited for an MRI scan in the lab. The Fellow will be trained in MRI analyses to investigate differences between and interactions among brain phenotypes linked to genotype, brain phenotype, and early adverse experiences. This work will shed light on the gene-brain-environment interactions that govern aggression, which is important for improving human-animal relationships, and has implications for understanding human mental health and social wellbeing.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该行动资助了2022财年的NSF生物学博士后研究奖学金，即调查基因组，环境和表型之间相互作用的生命规则的综合研究。该研究金支持研究员的研究和培训，以创新的方式为生活规则领域做出贡献。几个世纪以来，人类根据外观和行为特征选择性地饲养家犬。这种做法减少了品种之间的遗传差异，并导致了“自然实验”，为当前的研究人员提供了一个可控的机会，以了解驯化对行为的作用，并确定其生理基础。遗传学和神经科学等领域传统上在受控实验室环境中使用小鼠和大鼠等动物，现在正在寻找狗的答案，因为它们与人类共同进化的历史悠久。通过研究与人类生活在相同环境中的狗的基因-大脑-行为联系，有更大的潜力来了解生活在现实世界环境中的生理和行为是如何形成的。由于非常宽松的负选择和非常强大的正选择，某些特征可以在驯化物种中变得普遍。这些有害性状的存在已被证明在狗的行为和认知使用行为，遗传和脑成像。在一个多方法项目中，研究员将从这些独立的研究领域中获得见解，研究侵略的基因-大脑-行为表型，将行为评估调查与神经成像（MRI）和遗传分析相结合。该研究员将调查是否在侵略相关的大脑区域，遗传变异和个体生活史的形态和连接的系统差异发挥作用，在狗的侵略性表型。来自社区的宠物犬的初始样本将参与C-BARQ（已建立的行为评估工具）的行为预筛选。得分在前20%和后20%的攻击性量表的狗将参加额外的不良生活经历的筛查，为基因分型个体提供脸颊拭子，并被邀请在实验室进行MRI扫描。该研究员将接受MRI分析培训，以研究与基因型、大脑表型和早期不良经历相关的大脑表型之间的差异和相互作用。这项工作将揭示基因-大脑-环境的相互作用，控制侵略，这是重要的，改善人类与动物的关系，并有意义的理解人类的心理健康和社会福祉。这个奖项反映了NSF的法定使命，并已被认为是值得通过评估使用基金会的智力价值和更广泛的影响审查标准的支持。