LEAPS-MPS: CAS:Stimuli-Responsive Biodegradable Polymeric Nanomaterials for Biomedical Applications

LEAPS-MPS：CAS：用于生物医学应用的刺激响应性可生物降解聚合物纳米材料

• 批准号: 2213445
• 负责人: Binglin Sui
• 金额: $ 24.91万
• 依托单位: University of North Dakota Main Campus
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-15 至 2024-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2213445&HistoricalAwards=false
• 关键词: LEAPS; MPS; CAS; Stimuli; Responsive

This award is funded in whole or in part under the American Rescue Plan Act of 2021 (Public Law 117-2). In this project, funded by the Mathematical and Physical Sciences Directorate and housed in the Chemistry Division, Professor Binglin Sui and his students will work to develop a series of stimuli-responsive, biocompatible and biodegradable polymers and polymer-based nanomaterials that can be extensively utilized in the biological and medical worlds. Biosafety and sustainability have become two critical issues of bio-oriented nanomaterials with the rapid development of nanotechnology, resulting from the fact that those materials with nanoscale sizes could not be eliminated from the body and their accumulation in the body is likely to induce chronic systemic toxicities. The new polymers that Prof. Sui will develop consist of biodegradable polymer chains containing bio-cleavable chemical bonds. Therefore, in biological and physiological environments, the polymers and polymer-based nanomaterials will gradually break down and eventually turn into nontoxic small molecules in the body, devoid of biosafety and sustainability concerns. Prof. Sui will use cancer-related biomedical applications of the new materials to promote students’ awareness of human health issues and to get graduate and undergraduate students as well as the underrepresented Native American students from tribal colleges in North Dakota engaged in the research. Prof. Sui proposes to address the challenges of nanomaterials that are currently preventing the majority of materials with nanoscale sizes from biomedical applications, especially for bioimaging and nanomedicine. To that end, the new polymers are composed of biodegradable backbones containing bio-cleavable chemical bonds and stimuli-responsive and self-immolative side chains, bestowing the polymeric nanosystems capabilities of covalent conjugation of diagnostic, therapeutic, and genetic agents; controllable traceless-release of the conjugated agents on demand with maximal agent-releasing efficiency; and decomposition into nontoxic small molecules in the body after liberating loaded cargos, inducing no long-term concerns of biosafety and sustainability. The development of such materials expects to advance the evolution of bioimaging and nanomedicine into a biosafe, more reliable, and more efficient technique compared to traditional medicinal methods for the diagnosis, prevention, and treatment of diseases. Furthermore, the proposed strategy for solving the critical issues will pave the way for the development of more and more biosafe and sustainable polymers and nanomaterials. Prof. Sui plans to involve graduate and undergraduate students, especially underrepresented minority students in STEM fields, as well as high school students in the project to broaden the integration of research and participation-oriented outreach activities.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项是根据2021年《美国救援计划法》（公法117-2）全部或部分资助的。在这个项目中，由数学和物理科学局资助并在化学部门内置，Binglin Sui教授及其学生将努力开发一系列刺激性反应性，生物相容性和可生物降解的聚合物以及基于聚合物的纳米材料，这些纳米材料可在生物学和医疗世界中广泛利用。生物安全和可持续性已成为以生物为导向的纳米材料的两个关键问题，纳米技术的迅速发展是由于那些无法从体内消除纳米尺寸的材料，并且它们在体内的积累可能会诱导慢性全身毒性。 SUI教授将开发的新聚合物由含有生物裂解化学键的可生物降解聚合物链组成。因此，在生物学和物理环境中，聚合物和聚合物的纳米材料将逐渐分解，并最终变成体内无毒的小分子，而没有生物安全和可持续性问题。 SUI教授将使用与癌症相关的新材料的生物医学应用来促进学生对人类健康问题的认识，并吸引来自北达科他州部落学院的毕业生和本科生，以及从事这项研究的美国原住民学生。 SUI教授的提议解决了目前预防生物医学应用中大多数具有纳米尺寸的材料的纳米材料的挑战，尤其是生物成像和纳米医学。为此，新的聚合物由可生物降解的骨架组成，其中包含可生物裂化的化学键以及刺激反应性和自我透明性侧链，从而赋予了聚合物纳米系统的诊断，治疗性，治疗性和遗传性药物的共价共轭能力；连接代理的可控制的无透明释放，并具有最大释放效率的最大释放效率；在解放载荷后，分解为体内无毒的小分子，没有引起对生物安全和可持续性的长期关注。与传统的疾病诊断，预防和治疗的传统医学方法相比，这种材料的开发期望将生物成像和纳米医学的演变发展为生物安全，更可靠，更有效的技术。此外，解决关键问题的拟议战略将为开发越来越多的生物安全和可持续的聚合物和纳米材料铺平道路。 Prof. Sui plans to involve graduate and undergraduate students, especially underrepresented minority students in STEM fields, as well as high school students in the project to broaden the integration of research and participation-oriented outreach activities.This award reflects NSF's statutory mission and has been deemed honestly of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.