LEAPS-MPS: CAS:Stimuli-Responsive Biodegradable Polymeric Nanomaterials for Biomedical Applications

LEAPS-MPS：CAS：用于生物医学应用的刺激响应性可生物降解聚合物纳米材料

• 批准号: 2213445
• 负责人: Binglin Sui
• 金额: $ 24.91万
• 依托单位: University of North Dakota Main Campus
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-15 至 2024-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2213445&HistoricalAwards=false
• 关键词: LEAPS; MPS; CAS; Stimuli; Responsive

This award is funded in whole or in part under the American Rescue Plan Act of 2021 (Public Law 117-2). In this project, funded by the Mathematical and Physical Sciences Directorate and housed in the Chemistry Division, Professor Binglin Sui and his students will work to develop a series of stimuli-responsive, biocompatible and biodegradable polymers and polymer-based nanomaterials that can be extensively utilized in the biological and medical worlds. Biosafety and sustainability have become two critical issues of bio-oriented nanomaterials with the rapid development of nanotechnology, resulting from the fact that those materials with nanoscale sizes could not be eliminated from the body and their accumulation in the body is likely to induce chronic systemic toxicities. The new polymers that Prof. Sui will develop consist of biodegradable polymer chains containing bio-cleavable chemical bonds. Therefore, in biological and physiological environments, the polymers and polymer-based nanomaterials will gradually break down and eventually turn into nontoxic small molecules in the body, devoid of biosafety and sustainability concerns. Prof. Sui will use cancer-related biomedical applications of the new materials to promote students’ awareness of human health issues and to get graduate and undergraduate students as well as the underrepresented Native American students from tribal colleges in North Dakota engaged in the research. Prof. Sui proposes to address the challenges of nanomaterials that are currently preventing the majority of materials with nanoscale sizes from biomedical applications, especially for bioimaging and nanomedicine. To that end, the new polymers are composed of biodegradable backbones containing bio-cleavable chemical bonds and stimuli-responsive and self-immolative side chains, bestowing the polymeric nanosystems capabilities of covalent conjugation of diagnostic, therapeutic, and genetic agents; controllable traceless-release of the conjugated agents on demand with maximal agent-releasing efficiency; and decomposition into nontoxic small molecules in the body after liberating loaded cargos, inducing no long-term concerns of biosafety and sustainability. The development of such materials expects to advance the evolution of bioimaging and nanomedicine into a biosafe, more reliable, and more efficient technique compared to traditional medicinal methods for the diagnosis, prevention, and treatment of diseases. Furthermore, the proposed strategy for solving the critical issues will pave the way for the development of more and more biosafe and sustainable polymers and nanomaterials. Prof. Sui plans to involve graduate and undergraduate students, especially underrepresented minority students in STEM fields, as well as high school students in the project to broaden the integration of research and participation-oriented outreach activities.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项全部或部分根据2021年美国救援计划法案（公法117-2）资助。 在这个项目中，由数学和物理科学理事会资助，并设在化学部，教授Sui Binglin和他的学生将致力于开发一系列刺激响应，生物相容性和可生物降解的聚合物和聚合物基纳米材料，可广泛用于生物和医学世界。随着纳米技术的迅速发展，纳米材料的生物安全性和可持续性已成为生物导向纳米材料的两个关键问题，这是由于纳米尺度的材料在体内难以被清除，并且在体内积累可能引起慢性全身毒性。Sui教授将开发的新聚合物由含有生物可裂解化学键的可生物降解聚合物链组成。因此，在生物和生理环境中，聚合物和基于聚合物的纳米材料将逐渐分解，最终在体内变成无毒的小分子，没有生物安全性和可持续性问题。Sui教授将利用新材料在癌症相关生物医学领域的应用，提高学生对人类健康问题的认识，并让研究生和本科生以及来自北达科他州部落学院的少数美洲原住民学生参与研究。Sui教授提出解决纳米材料的挑战，这些挑战目前阻止了大多数纳米尺寸的材料在生物医学应用中的应用，特别是在生物成像和纳米医学中。为此，新聚合物由含有生物可裂解化学键和刺激响应性和自分解侧链的生物可降解主链组成，赋予聚合物纳米系统共价缀合诊断、治疗和遗传试剂的能力;缀合试剂的可控无痕释放，按需具有最大试剂释放效率;在释放装载的货物后，在体内分解成无毒的小分子，不会引起长期的生物安全和可持续性问题。这种材料的开发有望推动生物成像和纳米医学的发展，使其成为一种生物安全、更可靠、更有效的技术，而不是传统的医学方法来诊断、预防和治疗疾病。此外，解决关键问题的拟议战略将为开发越来越多的生物安全和可持续的聚合物和纳米材料铺平道路。隋教授计划让研究生和本科生，特别是在STEM领域代表性不足的少数民族学生，以及高中生参与该项目，以扩大研究和参与导向的外展活动的整合。该奖项反映了NSF的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。