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MRI: Acquisition of a Nanoindenter for Materials Science and Biomaterials Research

MRI: Acquisition of a Nanoindenter for Materials Science and Biomaterials Research
MRI:购买纳米压痕仪用于材料科学和生物材料研究
批准号:
2214855
负责人:
Robert Fleming
金额:
$58.62万
依托单位国家:
美国
项目类别:
Standard Grant
财政年份:
2022
资助国家:
美国
项目状态:
已结题
起止时间:
2022-09-01 至 2024-08-31

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中文摘要
翻译
这一重大研究仪器(MRI)奖支持收购一家纳米压头,用于先进工程材料和生物材料的基础研究。材料的机械性能与它们的功能有着千丝万缕的联系。了解这些特性如何影响材料的行为,对于先进工程材料的设计和生物组织对疾病的反应都是至关重要的。该仪器将能够对影响几个科学学科的材料进行定量的机械表征,并提供对工程、建筑和生物材料的基础理解。此外,有针对性的K-12教育外展活动将允许学生和教师参与动手实验并探索STEM职业生涯。这些机会将影响阿肯色州三角洲的低社会经济地位社区。这一纳米压头的获得将提供一个全面的纳米力学平台,用于定量测量材料的弹性模数、硬度、变形/磨损、疲劳强度和摩擦。该工具的独特功能将影响以下研究项目:1)研究新型高强度核壳纳米结构中的强化机制和作用位错动力学;2)评估龋病牙齿的硬度,以了解病原体变形链球菌是如何导致龋齿的;3)生理条件下心血管组织的体外力学表征;4)通过高分辨率的弹性模数、硬度和复合剪切模数的空间映射来了解聚合物沥青粘结剂的纳米机械性能;5)精密纳米制造研究,以改善薄膜润湿和脉冲电波产生的金属纳米颗粒表面的一致性;6)蓝宝石衬底上生长的III-V半导体量子点势垒的界面应变测量。总而言之,这些项目代表着工程和生物科学领域的多学科研究合作。该项目由土木、机械和制造创新部门(CMMI)、既定的激励竞争研究计划(EPSCoR)和重大仪器研究计划(MRI)联合资助。该奖项反映了NSF的法定使命,并通过使用基金会的智力优势和更广泛的影响审查标准进行评估,被认为值得支持。
英文摘要
This Major Research Instrumentation (MRI) award supports the acquisition of a nanoindenter for fundamental investigations of advanced engineering materials and biomaterials. The mechanical properties of materials are intricately linked to how they function. Understanding how these properties influence material behavior is critical for both the design of advanced engineered materials and the response of biological tissues to disease. This instrument will enable quantitative mechanical characterization of materials impacting several scientific disciplines and provide foundational understanding of engineering, construction, and biological materials. Additionally, targeted K-12 educational outreach activities will allow students and teachers to participate in hands-on experiments and explore STEM careers. These opportunities will impacting low socioeconomic status communities in the Arkansas Delta. This nanoindenter acquisition will provide a comprehensive nanomechanics platform for quantitatively measuring elastic modulus, hardness, deformation/wear, fatigue strength, and friction of materials. The unique capabilities of the tool will impact the following research projects: 1) Investigating strengthening mechanisms and the role dislocation dynamics in novel high-strength core-shell nanostructures; 2) Assessing the hardness of caries-affected teeth to understand how the pathogen Streptococcus mutans causes tooth decay; 3) in vitro mechanical characterization of cardiovascular tissues at physiological conditions; 4) Understanding the nanomechanistic properties of polymeric asphalt binders with high-resolution spatial mapping of elastic modulus, hardness, and complex shear modulus; 5) Precision nanomanufacturing research to improve the uniformity metallic nanopatterned surfaces produced by thin film dewetting and pulsed electric wave generation; and 6) interfacial strain measurements of III-V semiconductor quantum dot wells grown on sapphire. Together, these projects represent multi-disciplinary research collaborations across engineering and biological sciences. This project is jointly funded by the division of Civil, Mechanical and Manufacturing Innovation (CMMI), the Established Program to Stimulate Competitive Research (EPSCoR), and the Major Instrumentation Research Program (MRI).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
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RUI: Characterization of Notch Cis-Inhibitory Sequences in the Serrate Ligand of Drosophila Melanogaster
  • 批准号:
    1121214
  • 项目类别:
    Standard Grant
  • 资助金额:
    $31.67万
  • 财政年份:
    2011
  • 负责人:
    Robert Fleming
  • 依托单位:
RUI: Gene-Specific Importin Alpha Functions in Development
  • 批准号:
    0234751
  • 项目类别:
    Standard Grant
  • 资助金额:
    $13.03万
  • 财政年份:
    2003
  • 负责人:
    Robert Fleming
  • 依托单位:
Functional Signaling Domains of Notch Ligands
  • 批准号:
    9727951
  • 项目类别:
    Continuing Grant
  • 资助金额:
    $35.11万
  • 财政年份:
    1998
  • 负责人:
    Robert Fleming
  • 依托单位:
Serrate: Neurogenic interactions and intercellular signaling
  • 批准号:
    9418678
  • 项目类别:
    Continuing Grant
  • 资助金额:
    $33.63万
  • 财政年份:
    1995
  • 负责人:
    Robert Fleming
  • 依托单位:
海外基金