MRI: Acquisition of a Gel Permeation Chromatography System with Dynamic Light Scattering Capabilities to Advance Research and Instructional Activities at Murray State University

MRI：采购具有动态光散射功能的凝胶渗透色谱系统，以推进默里州立大学的研究和教学活动

• 批准号: 2215040
• 负责人: Kevin Miller
• 金额: $ 22.36万
• 依托单位: Murray State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2025-07-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2215040&HistoricalAwards=false
• 关键词: MRI; Acquisition; Gel; Permeation; Chromatography

This award is jointly supported by the Major Research Instrumentation, the Established Program to Stimulate Competitive Research (EPSCoR), and the Chemistry Research Instrumentation Programs. Murray State University is acquiring a gel permeation chromatography system with dynamic light scattering detection (GPC/DLS) to support the research of Professor Kevin Miller and colleagues Gary Stinchcomb, Bikram Subedi, Christopher Lennon, and Grace Eder. This instrument facilitates research in the areas of chemistry, biological sciences, and Earth and environmental sciences. GPC separates molecules as a function of size based on their elution from a packed column. DLS is subsequently used, in-line, to measure time-dependent fluctuations in scattered light, which is related to molecular diffusion coefficeints and their size distributions. This instrument enhances the educational, research, and teaching efforts of students at all levels in many departments as well as provides accessibility for use at nearby institutions. The instrument is leveraged in research training opportunities in polymer chemistry, molecular biology, and environmental science. Students gain hands-on experience with the instrument through its integration in various courses.The award of the GPC/DLS is aimed at enhancing research and education at all levels, especially in areas such as polymer chemistry, molecular biology, and environmental science. Research focuses on molecular weight analysis of ionenes and cellulose functionalized with ionic liquids and poly(ionic liquids). Other investigations include the separation and analysis of drug residues and other small molecules from biological tissue, environmental samples, and wastewater. It also assists in analyzing molecular weight distributions of copolymers for organic photovoltaics.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器，刺激竞争性研究的既定计划（EPSCoR）和化学研究仪器计划共同支持。Murray州立大学正在收购一种具有动态光散射检测（GPC/DLS）的凝胶渗透色谱系统，以支持Kevin米勒教授及其同事加里斯廷奇科姆、Bikram Subedi、克里斯托弗·列侬和格蕾丝·埃德的研究。这一仪器促进了化学、生物科学以及地球和环境科学领域的研究。GPC基于分子从填充柱的洗脱将分子分离为尺寸的函数。DLS随后被用于在线测量散射光的时间依赖性波动，这与分子扩散系数及其尺寸分布有关。该工具增强了许多部门各级学生的教育，研究和教学努力，并提供了在附近机构使用的无障碍环境。该仪器在高分子化学，分子生物学和环境科学的研究培训机会中发挥作用。GPC/DLS奖旨在加强各个层面的研究和教育，特别是在高分子化学、分子生物学和环境科学等领域。研究重点是离子液体和聚离子液体功能化的紫罗烯和纤维素的分子量分析。其他研究包括从生物组织、环境样品和废水中分离和分析药物残留物和其他小分子。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。