MRI: Acquisition of the First 800 MHz NMR with Cryoprobe in the State of Mississippi for Biological and Chemical Research and Teaching

密西西比州立大学(MSU)被授予支持购买800 MHz核磁共振(核磁共振)光谱仪的奖励。该仪器将支持密西西比州和东南部的研究人员，在生物分子相互作用、有机金属化学和聚合物材料方面开辟新的研究途径。该项目将支持各级研究人员的多样化社区，从本科生到附近PUI和HBCU的教职员工。学生们可以通过密歇根州立大学的课程直接接触到这种新仪器，包括“溶液核磁共振波谱理论”。此外，密歇根州立大学的“环境化学”课程将以仪器安装和氦的使用为特色。除了通过密歇根州立大学提供的课程和研讨会受益的其他用户外，共有19名调查人员、研究生、72名本科生和7名博士后实习生将直接和立即受到该项目的影响。这些受训人员中的许多人将代表少数民族或第一代大学生。新仪器将使生物分子和化学研究成为可能，这在密西西比州目前是不可能的。这是因为与该区域现有的仪器相比，新仪器大大提高了灵敏度和分辨率。生物研究人员将使用这种新型核磁共振光谱仪(1)探索微生物如何附着在表面，(2)了解心脏中离子通道是如何调节的，(3)表征基于金属离子的基因调节机制，以及(4)监测小分子如何对新陈代谢的变化做出反应。化学研究人员将利用该仪器开发合成聚合物和有机金属材料的新方法，该仪器包括一个宽带探测器，用于检测27Al、29Si和195Pt等非标准核。在新的800 MHz核磁共振上收集的数据将在科学会议和同行评议的出版物中广泛共享。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

An award is made to Mississippi State University (MSU) to support the acquisition of an 800 MHz nuclear magnetic resonance (NMR) spectrometer. This instrument will support researchers throughout Mississippi and the southeast, enabling new research avenues in biomolecular interactions, organometallic chemistry, and polymeric materials. This project will support a diverse community of researchers at all levels, from undergraduate students to faculty at nearby PUIs and HBCUs. Students can access the new instrument firsthand through course offerings at MSU, including “Theory of Solution NMR Spectroscopy.” Moreover, MSU’s “Environmental Chemistry” course will feature instrument installation and helium use. A total of 19 investigators, 64 graduate students, 72 undergraduate students, and 7 postdoctoral trainees will be directly and immediately impacted by this project, in addition to other users who benefit through classes and workshops offered at MSU. Many of these trainees will represent ethnic minorities or first-generation college students.The new instrument will enable biomolecular and chemical research not currently possible in Mississippi. This is because the new instrument has significantly increased sensitivity and resolution over the current instrumentation available in the region. Biological researchers will use this new NMR spectrometer (1) to explore how microorganisms attach to surfaces, (2) to understand how ion channels are regulated in the heart, (3) to characterize the mechanism of metal-ion-based gene regulation, and (4) to monitor how small molecules respond to changes in metabolism. Chemical researchers will use the instrument to develop new methods for synthesizing polymeric and organometallic materials, and the instrument includes a broadband probe for detecting nonstandard nuclei such as 27Al, 29Si, and 195Pt. Data collected on the new 800 MHz NMR will be shared broadly at scientific meetings and in peer-reviewed publications.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.