MRI: Acquisition of the First 800 MHz NMR with Cryoprobe in the State of Mississippi for Biological and Chemical Research and Teaching

MRI：在密西西比州购买第一台带有冷冻探头的 800 MHz NMR，用于生物和化学研究和教学

• 批准号: 2215258
• 负责人: Nicholas Fitzkee
• 金额: $ 220.31万
• 依托单位: Mississippi State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-10-01 至 2025-09-30
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2215258&HistoricalAwards=false
• 关键词: MRI; Acquisition; First; 800; MHz

An award is made to Mississippi State University (MSU) to support the acquisition of an 800 MHz nuclear magnetic resonance (NMR) spectrometer. This instrument will support researchers throughout Mississippi and the southeast, enabling new research avenues in biomolecular interactions, organometallic chemistry, and polymeric materials. This project will support a diverse community of researchers at all levels, from undergraduate students to faculty at nearby PUIs and HBCUs. Students can access the new instrument firsthand through course offerings at MSU, including “Theory of Solution NMR Spectroscopy.” Moreover, MSU’s “Environmental Chemistry” course will feature instrument installation and helium use. A total of 19 investigators, 64 graduate students, 72 undergraduate students, and 7 postdoctoral trainees will be directly and immediately impacted by this project, in addition to other users who benefit through classes and workshops offered at MSU. Many of these trainees will represent ethnic minorities or first-generation college students.The new instrument will enable biomolecular and chemical research not currently possible in Mississippi. This is because the new instrument has significantly increased sensitivity and resolution over the current instrumentation available in the region. Biological researchers will use this new NMR spectrometer (1) to explore how microorganisms attach to surfaces, (2) to understand how ion channels are regulated in the heart, (3) to characterize the mechanism of metal-ion-based gene regulation, and (4) to monitor how small molecules respond to changes in metabolism. Chemical researchers will use the instrument to develop new methods for synthesizing polymeric and organometallic materials, and the instrument includes a broadband probe for detecting nonstandard nuclei such as 27Al, 29Si, and 195Pt. Data collected on the new 800 MHz NMR will be shared broadly at scientific meetings and in peer-reviewed publications.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

美国密西西比州立大学（MSU）获得了一份合同，以支持购买一台800兆赫的核磁共振（NMR）光谱仪。该仪器将支持整个密西西比州和东南部的研究人员，在生物分子相互作用、有机金属化学和聚合物材料方面开辟新的研究途径。该项目将支持不同层次的研究人员，从本科生到附近PUIs和hbcu的教师。学生可以通过密歇根州立大学提供的课程直接使用新仪器，包括“溶液核磁共振光谱学理论”。此外，密歇根州立大学的“环境化学”课程将以仪器安装和氦气使用为特色。共有19名研究人员、64名研究生、72名本科生和7名博士后实习生将直接受到该项目的影响，此外还有其他用户从密歇根州立大学提供的课程和研讨会中受益。这些受训者中有许多是少数民族或第一代大学生。新仪器将使生物分子和化学研究成为可能，目前在密西西比州是不可能的。这是因为与该地区现有仪器相比，新仪器的灵敏度和分辨率显著提高。生物学研究人员将使用这种新的核磁共振光谱仪(1)探索微生物如何附着在表面上，(2)了解心脏中离子通道是如何调节的，(3)表征金属离子基基因调控的机制，(4)监测小分子如何响应代谢变化。化学研究人员将使用该仪器开发合成聚合物和有机金属材料的新方法，该仪器包括一个宽带探针，用于检测非标准核，如27Al， 29Si和195Pt。在新的800兆赫核磁共振上收集的数据将在科学会议和同行评议的出版物中广泛分享。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。