MRI: Acquisition of Crystallographic Equipment and Excellence in Crystallographic Science and Education at Temple University and the Surrounding Community

该奖项由主要研究仪器和化学研究仪器项目联合支持。天普大学正在购买一个双源单晶衍射仪，以支持Michael Zdilla教授、同事Richard H Baxter以及8名高级人员和16名合作者的研究。一般来说，x射线衍射仪可以精确测量分子的完整三维结构，包括键距和角度，并提供有关分子相对于邻近分子的空间排列的准确信息。这里描述的研究影响了许多领域，如合成有机和无机化学，催化，材料，物理，纳米科学，工程，能源科学，生物化学，化学生物学和结构生物学。该仪器是化学、生物化学、制药和工程等多学科本科生和研究生教学、研究和研究训练的重要组成部分。该设施作为区域XRD资源，使天普大学和周边社区的学生和教师受益。例如，有许多用户位于德雷塞尔大学。该奖项旨在加强各级的研究和教育。该仪器支持的研究主要集中在无机化学、材料和晶体学方面的研究，包括对能源科学有影响的过渡金属簇的合成。含硫酯蛋白1 （TEP1）晶体结构和蚊子特异性富亮氨酸重复序列（LRR）蛋白、富亮氨酸重复序列免疫蛋白（LRIMs）的晶体结构将使昆虫宿主对病媒传播疾病的先天免疫发挥作用。含硫酯蛋白1是疟疾病媒冈比亚按蚊对疟原虫反应的关键因子。用于锂或钠离子/金属电池的固体或凝胶电解质的开发研究将依赖于重要化合物的SCXRD。研究人员将能够评估潜在催化剂的结构特性，并改进更快速、更准确地生产有机分子的方法。在碳酸酐酶抑制剂（CAIs）和活化剂（CAAs）的设计、合成、纯化、表征和生物学测试中，在不同分子量的两亲体（简单和双表面活性剂、脂质、双表面活性剂）的合成和自组装研究中，将利用XRD研究不同超分子体系（超分子树状大分子、负载脂质双层和脂质体）的自组装和胶体稳定性。树突、树突和聚合物)以及它们在癌症治疗中作为传递系统的应用。螺旋体的研究需要小分子和大分子XRD来表征这些更大的结构。XRD将帮助生成能够揭示翻译后修饰（PTMs）的分子机制或针对PTMs新发现的蛋白质-蛋白质相互作用（PPIs）关键的探针。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This award is jointly supported by the Major Research Instrumentation and the Chemistry Research Instrumentation Programs. Temple University is acquiring a dual-source single crystal diffractometer to support the research of Professor Michael Zdilla, colleague Richard H Baxter, as well as eight senior personnel, and sixteen collaborators. In general, an X-ray diffractometer allows accurate and precise measurements of the full three-dimensional structure of a molecule, including bond distances and angles, and provides accurate information about the spatial arrangement of a molecule relative to neighboring molecules. The studies described here impact many areas such as, synthetic organic and inorganic chemistry, catalysis, materials, physics, nanoscience, engineering, energy science, biochemistry, chemical biology, and structural biology. This instrument is an integral part of teaching as well as research and research training of undergraduate and graduate students in multiple disciplines including chemistry, biochemistry, pharmacy and engineering. The facility serves as a regional XRD resource benefitting students and faculty from Temple and in the surrounding community. For example, there are numerous users located at Drexel University. The award is aimed at enhancing research and education at all levels. Research enabled by the instrument is focused on research in inorganic chemistry, materials, and crystallography, including the synthesis of transition metal clusters with implications for energy science. The role of innate immunity in insect hosts for vector- borne diseases will be enabled with the crystal structures of thioester-containing protein 1 (TEP1), a key factor in the response of the malaria vector Anopheles gambiae to Plasmodium, and the mosquito-specific leucine-rich repeat (LRR) proteins, Leucine-rich repeat immune proteins (LRIMs). Research on the development of solid or gel electrolytes for lithium or sodium ion/metal batteries will rely on SCXRD of important compounds. Researcher will be able to assess structural properties of potential catalysts and refine methods for production of organic molecules more rapidly and accurately. XRD will be used to investigate the self-assembly and colloidal stability of different supramolecular systems (supramolecular dendrimers, supported lipid bilayers and liposomes), in the design, synthesis, purification, characterization and biological testing of carbonic anhydrase inhibitors (CAIs) and activators (CAAs), synthesis and self-assembling study of amphiphiles of different molecular weights (simple and gemini surfactants, lipids, dendrons and dendrimers and polymers) and their use as delivery systems in cancer treatment. Work on spiroligomers requires both small molecule and macromolecular XRD to characterize these ever-larger structures. XRD will assist in the generation of probes that can unravel molecular mechanisms underlying post-translational modifications (PTMs) or target newly revealed protein-protein interactions (PPIs) key to PTMs.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.