MRI: Acquisition of Crystallographic Equipment and Excellence in Crystallographic Science and Education at Temple University and the Surrounding Community

该奖项由主要研究仪器项目和化学研究仪器项目共同支持。坦普尔大学正在购买一台双源单晶衍射仪，以支持迈克尔·兹迪拉教授、同事理查德·H·巴克斯特以及8名高级人员和16名合作者的研究。通常，X射线衍射仪可以准确和精确地测量分子的完整三维结构，包括键距离和角度，并提供关于分子相对于邻近分子的空间排列的准确信息。这里介绍的研究影响到许多领域，如合成有机化学和无机化学、催化、材料、物理、纳米科学、工程、能源科学、生物化学、化学生物学和结构生物学。该仪器是包括化学、生物化学、药学和工程学在内的多个学科的本科生和研究生的教学、研究和研究培训的组成部分。该设施作为一个地区性的X射线衍生品资源，使坦普尔和周围社区的学生和教职员工受益。例如，在德雷克塞尔大学有很多用户。该奖项旨在加强各级的研究和教育。该仪器的研究重点是无机化学、材料和结晶学方面的研究，包括具有能源科学意义的过渡金属簇合物的合成。媒介传播疾病的昆虫宿主的先天免疫作用将通过硫酯蛋白1(TEP1)的晶体结构和蚊子特有的富亮氨酸重复蛋白(LRIMs)来实现。TEP1是疟疾媒介冈比亚按蚊对疟疾的反应的关键因子。锂或钠离子/金属电池固体或凝胶电解液的研究将依赖于重要化合物的SCX射线。研究人员将能够评估潜在催化剂的结构特性，并更快、更准确地改进生产有机分子的方法。不同超分子体系(超分子树枝状大分子、负载型脂质双层和脂质体)的自组装和胶体稳定性，碳酸酐酶抑制剂(CAI)和激活剂(CAAs)的设计、合成、纯化、表征和生物学测试，不同分子量的两亲分子(简单和双子表面活性剂、脂类、树枝和树枝状大分子和聚合物)的合成和自组装研究，以及它们作为癌症治疗递送系统的应用，都将被用来研究X射线衍射。螺环异构体的研究需要小分子和大分子的X射线衍射仪来表征这些越来越大的结构。X射线衍射仪将帮助产生探针，这些探针可以解开翻译后修饰(PTM)潜在的分子机制，或针对新发现的蛋白质-蛋白质相互作用(PPI)，这些蛋白质-蛋白质相互作用是翻译后修饰的关键。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

This award is jointly supported by the Major Research Instrumentation and the Chemistry Research Instrumentation Programs. Temple University is acquiring a dual-source single crystal diffractometer to support the research of Professor Michael Zdilla, colleague Richard H Baxter, as well as eight senior personnel, and sixteen collaborators. In general, an X-ray diffractometer allows accurate and precise measurements of the full three-dimensional structure of a molecule, including bond distances and angles, and provides accurate information about the spatial arrangement of a molecule relative to neighboring molecules. The studies described here impact many areas such as, synthetic organic and inorganic chemistry, catalysis, materials, physics, nanoscience, engineering, energy science, biochemistry, chemical biology, and structural biology. This instrument is an integral part of teaching as well as research and research training of undergraduate and graduate students in multiple disciplines including chemistry, biochemistry, pharmacy and engineering. The facility serves as a regional XRD resource benefitting students and faculty from Temple and in the surrounding community. For example, there are numerous users located at Drexel University. The award is aimed at enhancing research and education at all levels. Research enabled by the instrument is focused on research in inorganic chemistry, materials, and crystallography, including the synthesis of transition metal clusters with implications for energy science. The role of innate immunity in insect hosts for vector- borne diseases will be enabled with the crystal structures of thioester-containing protein 1 (TEP1), a key factor in the response of the malaria vector Anopheles gambiae to Plasmodium, and the mosquito-specific leucine-rich repeat (LRR) proteins, Leucine-rich repeat immune proteins (LRIMs). Research on the development of solid or gel electrolytes for lithium or sodium ion/metal batteries will rely on SCXRD of important compounds. Researcher will be able to assess structural properties of potential catalysts and refine methods for production of organic molecules more rapidly and accurately. XRD will be used to investigate the self-assembly and colloidal stability of different supramolecular systems (supramolecular dendrimers, supported lipid bilayers and liposomes), in the design, synthesis, purification, characterization and biological testing of carbonic anhydrase inhibitors (CAIs) and activators (CAAs), synthesis and self-assembling study of amphiphiles of different molecular weights (simple and gemini surfactants, lipids, dendrons and dendrimers and polymers) and their use as delivery systems in cancer treatment. Work on spiroligomers requires both small molecule and macromolecular XRD to characterize these ever-larger structures. XRD will assist in the generation of probes that can unravel molecular mechanisms underlying post-translational modifications (PTMs) or target newly revealed protein-protein interactions (PPIs) key to PTMs.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.