MRI: Acquisition of Crystallographic Equipment and Excellence in Crystallographic Science and Education at Temple University and the Surrounding Community

MRI：天普大学及周边社区晶体学设备的采购和卓越的晶体学科学与教育

• 批准号: 2215854
• 负责人: Michael Zdilla
• 金额: $ 29万
• 依托单位: Temple University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2025-07-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2215854&HistoricalAwards=false
• 关键词: MRI; Acquisition; Crystallographic; Equipment; Excellence

This award is jointly supported by the Major Research Instrumentation and the Chemistry Research Instrumentation Programs. Temple University is acquiring a dual-source single crystal diffractometer to support the research of Professor Michael Zdilla, colleague Richard H Baxter, as well as eight senior personnel, and sixteen collaborators. In general, an X-ray diffractometer allows accurate and precise measurements of the full three-dimensional structure of a molecule, including bond distances and angles, and provides accurate information about the spatial arrangement of a molecule relative to neighboring molecules. The studies described here impact many areas such as, synthetic organic and inorganic chemistry, catalysis, materials, physics, nanoscience, engineering, energy science, biochemistry, chemical biology, and structural biology. This instrument is an integral part of teaching as well as research and research training of undergraduate and graduate students in multiple disciplines including chemistry, biochemistry, pharmacy and engineering. The facility serves as a regional XRD resource benefitting students and faculty from Temple and in the surrounding community. For example, there are numerous users located at Drexel University. The award is aimed at enhancing research and education at all levels. Research enabled by the instrument is focused on research in inorganic chemistry, materials, and crystallography, including the synthesis of transition metal clusters with implications for energy science. The role of innate immunity in insect hosts for vector- borne diseases will be enabled with the crystal structures of thioester-containing protein 1 (TEP1), a key factor in the response of the malaria vector Anopheles gambiae to Plasmodium, and the mosquito-specific leucine-rich repeat (LRR) proteins, Leucine-rich repeat immune proteins (LRIMs). Research on the development of solid or gel electrolytes for lithium or sodium ion/metal batteries will rely on SCXRD of important compounds. Researcher will be able to assess structural properties of potential catalysts and refine methods for production of organic molecules more rapidly and accurately. XRD will be used to investigate the self-assembly and colloidal stability of different supramolecular systems (supramolecular dendrimers, supported lipid bilayers and liposomes), in the design, synthesis, purification, characterization and biological testing of carbonic anhydrase inhibitors (CAIs) and activators (CAAs), synthesis and self-assembling study of amphiphiles of different molecular weights (simple and gemini surfactants, lipids, dendrons and dendrimers and polymers) and their use as delivery systems in cancer treatment. Work on spiroligomers requires both small molecule and macromolecular XRD to characterize these ever-larger structures. XRD will assist in the generation of probes that can unravel molecular mechanisms underlying post-translational modifications (PTMs) or target newly revealed protein-protein interactions (PPIs) key to PTMs.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器和化学研究仪器计划共同支持。天普大学正在购买一台双源单晶衍射仪，以支持Michael Zdilla教授、同事Richard H巴克斯特以及8名高级人员和16名合作者的研究。一般来说，X射线衍射仪允许准确和精确地测量分子的完整三维结构，包括键距和角度，并提供关于分子相对于相邻分子的空间排列的准确信息。这里描述的研究影响许多领域，如合成有机和无机化学，催化，材料，物理，纳米科学，工程，能源科学，生物化学，化学生物学和结构生物学。该仪器是教学的一个组成部分，以及研究和研究培训的本科生和研究生在多个学科，包括化学，生物化学，药学和工程。该设施作为区域XRD资源，使坦普尔和周边社区的学生和教师受益。例如，有许多用户位于德雷克塞尔大学。该奖项旨在加强各级的研究和教育。该仪器的研究重点是无机化学，材料和晶体学的研究，包括过渡金属簇合物的合成与能源科学的影响。先天免疫在昆虫宿主中对媒介传播疾病的作用将通过含硫酯蛋白1（TEP 1）的晶体结构和蚊子特异性富含亮氨酸重复序列（LRR）蛋白、富含亮氨酸重复序列免疫蛋白（LRIM）来实现，所述含硫酯蛋白1（TEP 1）是疟疾媒介冈比亚按蚊（Anopheles gambiae）对疟原虫应答的关键因子。锂或钠离子/金属电池固体或凝胶电解质的开发研究将依赖于重要化合物的SCXRD。研究人员将能够评估潜在催化剂的结构特性，并更快速准确地改进生产有机分子的方法。XRD将用于研究不同超分子体系的自组装和胶体稳定性（超分子树枝状聚合物、支撑的脂质双层和脂质体），在碳酸酐酶抑制剂（CAI）和激活剂（CAA）的设计、合成、纯化、表征和生物测试中，不同分子量的两亲物的合成和自组装研究（简单和双子表面活性剂、脂质、树枝状分子（dendron）和树枝状聚合物（dendrimer）和聚合物）及其在癌症治疗中作为递送系统的用途。螺旋低聚物的研究需要小分子和大分子XRD来表征这些更大的结构。 XRD将帮助开发出能够揭示翻译后修饰（PTM）的分子机制或靶向新发现的关键PTM的蛋白质-蛋白质相互作用（PPI）的探针。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。