MRI: Acquisition of Crystallographic Equipment and Excellence in Crystallographic Science and Education at Temple University and the Surrounding Community

MRI:天普大学及周边社区晶体学设备的采购和卓越的晶体学科学与教育

基本信息

  • 批准号:
    2215854
  • 负责人:
  • 金额:
    $ 29万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-08-15 至 2025-07-31
  • 项目状态:
    未结题

项目摘要

This award is jointly supported by the Major Research Instrumentation and the Chemistry Research Instrumentation Programs. Temple University is acquiring a dual-source single crystal diffractometer to support the research of Professor Michael Zdilla, colleague Richard H Baxter, as well as eight senior personnel, and sixteen collaborators. In general, an X-ray diffractometer allows accurate and precise measurements of the full three-dimensional structure of a molecule, including bond distances and angles, and provides accurate information about the spatial arrangement of a molecule relative to neighboring molecules. The studies described here impact many areas such as, synthetic organic and inorganic chemistry, catalysis, materials, physics, nanoscience, engineering, energy science, biochemistry, chemical biology, and structural biology. This instrument is an integral part of teaching as well as research and research training of undergraduate and graduate students in multiple disciplines including chemistry, biochemistry, pharmacy and engineering. The facility serves as a regional XRD resource benefitting students and faculty from Temple and in the surrounding community. For example, there are numerous users located at Drexel University. The award is aimed at enhancing research and education at all levels. Research enabled by the instrument is focused on research in inorganic chemistry, materials, and crystallography, including the synthesis of transition metal clusters with implications for energy science. The role of innate immunity in insect hosts for vector- borne diseases will be enabled with the crystal structures of thioester-containing protein 1 (TEP1), a key factor in the response of the malaria vector Anopheles gambiae to Plasmodium, and the mosquito-specific leucine-rich repeat (LRR) proteins, Leucine-rich repeat immune proteins (LRIMs). Research on the development of solid or gel electrolytes for lithium or sodium ion/metal batteries will rely on SCXRD of important compounds. Researcher will be able to assess structural properties of potential catalysts and refine methods for production of organic molecules more rapidly and accurately. XRD will be used to investigate the self-assembly and colloidal stability of different supramolecular systems (supramolecular dendrimers, supported lipid bilayers and liposomes), in the design, synthesis, purification, characterization and biological testing of carbonic anhydrase inhibitors (CAIs) and activators (CAAs), synthesis and self-assembling study of amphiphiles of different molecular weights (simple and gemini surfactants, lipids, dendrons and dendrimers and polymers) and their use as delivery systems in cancer treatment. Work on spiroligomers requires both small molecule and macromolecular XRD to characterize these ever-larger structures. XRD will assist in the generation of probes that can unravel molecular mechanisms underlying post-translational modifications (PTMs) or target newly revealed protein-protein interactions (PPIs) key to PTMs.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
该奖项由主要研究仪器和化学研究仪器计划共同支持。天普大学正在购买一台双源单晶衍射仪,以支持Michael Zdilla教授、同事Richard H巴克斯特以及8名高级人员和16名合作者的研究。一般来说,X射线衍射仪允许准确和精确地测量分子的完整三维结构,包括键距和角度,并提供关于分子相对于相邻分子的空间排列的准确信息。这里描述的研究影响许多领域,如合成有机和无机化学,催化,材料,物理,纳米科学,工程,能源科学,生物化学,化学生物学和结构生物学。该仪器是教学的一个组成部分,以及研究和研究培训的本科生和研究生在多个学科,包括化学,生物化学,药学和工程。该设施作为一个区域XRD资源受益于学生和教师从寺和周围社区。例如,有许多用户位于德雷克塞尔大学。该奖项旨在加强各级的研究和教育。该仪器的研究重点是无机化学,材料和晶体学的研究,包括过渡金属簇合物的合成与能源科学的影响。先天免疫在昆虫宿主中对媒介传播疾病的作用将通过含硫酯蛋白1(TEP 1)的晶体结构和蚊子特异性富含亮氨酸重复序列(LRR)蛋白、富含亮氨酸重复序列免疫蛋白(LRIM)来实现,所述含硫酯蛋白1(TEP 1)是疟疾媒介冈比亚按蚊(Anopheles gambiae)对疟原虫应答的关键因子。锂或钠离子/金属电池固体或凝胶电解质的开发研究将依赖于重要化合物的SCXRD。研究人员将能够评估潜在催化剂的结构特性,并更快速准确地改进生产有机分子的方法。XRD将用于研究不同超分子体系的自组装和胶体稳定性(超分子树枝状聚合物、支撑的脂质双层和脂质体),在碳酸酐酶抑制剂(CAI)和激活剂(CAA)的设计、合成、纯化、表征和生物测试中,不同分子量的两亲物的合成和自组装研究(简单和双子表面活性剂、脂质、树枝状分子(dendron)和树枝状聚合物(dendrimer)和聚合物)及其在癌症治疗中作为递送系统的用途。螺旋低聚物的研究需要小分子和大分子XRD来表征这些更大的结构。 XRD将帮助开发出能够揭示翻译后修饰(PTM)的分子机制或靶向新发现的关键PTM的蛋白质-蛋白质相互作用(PPI)的探针。该奖项反映了NSF的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。

项目成果

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Michael Zdilla其他文献

Michael Zdilla的其他文献

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{{ truncateString('Michael Zdilla', 18)}}的其他基金

Moldable, self-healing, highly conductive organic co-crystalline solid electrolytes for safer lithium ion batteries
可成型、自修复、高导电性有机共晶固体电解质,用于更安全的锂离子电池
  • 批准号:
    2138432
  • 财政年份:
    2022
  • 资助金额:
    $ 29万
  • 项目类别:
    Continuing Grant
Conformationally-flexible, reactive manganese clusters to probe possible mechanisms of oxygen-oxygen bond formation in photosystem II
构象灵活的反应性锰簇探索光系统 II 中氧-氧键形成的可能机制
  • 批准号:
    1800105
  • 财政年份:
    2018
  • 资助金额:
    $ 29万
  • 项目类别:
    Continuing Grant
SusChEM: Molecular organic frameworks for solid state ion channels with exceedingly simple design: Toward barrier-less ion migration
SusChEM:设计极其简单的固态离子通道的分子有机框架:实现无屏障离子迁移
  • 批准号:
    1437814
  • 财政年份:
    2014
  • 资助金额:
    $ 29万
  • 项目类别:
    Standard Grant
CAREER / SusChEM: Bio-inspired synthesis of conformationally flexible analogues of the biological oxygen evolving complex: A redesigned approach to manganese cluster molecules
职业 / SusChEM:生物放氧复合物构象灵活类似物的仿生合成:锰簇分子的重新设计方法
  • 批准号:
    1254545
  • 财政年份:
    2013
  • 资助金额:
    $ 29万
  • 项目类别:
    Standard Grant

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获取 EBSD 系统,用于绘制地球和行星材料的相和晶体取向图
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获得最先进的晶体簇
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先进光源下生物和化学研究晶体学数据采集系统的开发
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    9601657
  • 财政年份:
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购置用于晶体学和岩石学计算的计算机工作站
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获取用于大分子晶体学研究的多线区域检测器系统
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获得用于高温高压研究的新型 X 射线晶体学系统
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Acquisition of a New X-Ray Crystallographic System For Research at High Temperature and High Pressure
获得用于高温高压研究的新型 X 射线晶体学系统
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