MRI: Acquisition of an Ultra High Performance Liquid Chromatograph with a Tandem High Resolution Mass Spectrometer for Research and Training in Basic and Applied Sciences

该奖项由主要研究仪器项目和化学研究仪器项目共同支持。田纳西中部州立大学正在购买一台配备串联高分辨率质谱仪(UHPLCMS)的超高性能液相色谱仪，以支持张梦亮教授及其同事Andrienne Friedli、Ngee-Sing Chong、Tony Johnston和Ying Gao的研究。该仪器促进了法医学、医学、有机、农业和材料化学等领域的研究。UHPLCMS是一种分析仪器，它结合了液相色谱的物理分离能力和质谱学的质量分析能力。通常，质谱仪是用于识别和表征复杂样品中的少量化学物种的关键分析方法之一。在一个典型的实验中，这些成分被加热并流入质谱仪，在那里它们被电离。离子的质量测量得非常准确。这种高度灵敏的技术使研究复杂混合物中的分子结构成为可能。带有液体色谱仪的仪器可以在混合物到达质谱计之前将其分离。各种电离源为所分析的样品类型提供了额外的灵活性。此次收购加强了该大学和该地区的研究基础设施。这一工具加强了许多部门各级学生的教育、研究和教学努力，并提供了在附近机构使用的便利条件。该仪器将用于培训学生群体，其中有很大比例的女性和在化学科学中代表性不足的种族群体。来自低收入背景的学生和大学第一代大学生的比例表明，该项目有能力影响这些学生参与STEM。该仪器给学生提供了使用重要仪器的经验，他们将把这些仪器带到他们的职业生涯中。授予这种质谱仪的目的是为了加强各级的研究和教育。它特别影响到取证、医药、有机、农业和材料化学等领域。研究的重点是筛选化学特征和确定化学鉴定的特征，鉴定生物标记物，药物发现，作为抗真菌、抗炎和抗癌药物的合成产品的开发，对发酵和植物化学转化的详细了解，以及类肽的测序。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

This award is jointly supported by the Major Research Instrumentation and the Chemistry Research Instrumentation Programs. Middle Tennessee State University is acquiring an ultra high performance liquid chromatograph with a tandem high resolution mass spectrometer (UHPLC MS) to support the research of Professor Mengliang Zhang and colleagues Andrienne Friedli, Ngee-Sing Chong, Tony Johnston, and Ying Gao. This instrument facilitates research in the areas of forensics, medicinal, organic, agricultural and materials chemistry. UHPLC MS is an analytical instrument that combines the physical separation capabilities of liquid chromatography with the mass analysis capabilities of mass spectrometry. In general, mass spectrometry (MS) is one of the key analytical methods used to identify and characterize small quantities of chemical species embedded in complex samples. In a typical experiment, the components are heated and flow into a mass spectrometer where they are ionized. The ions' masses are measured very accurately. This highly sensitive technique allows the structure of molecules in complex mixtures to be studied. An instrument with a liquid chromatograph can separate mixtures of compounds before they reach the mass spectrometer. The various ionization sources provide added flexibility with regard to the types of samples that are analyzed. The acquisition strengthens the research infrastructure at the University and regional area. This instrument enhances the educational, research, and teaching efforts of students at all levels in many departments as well as provides accessibility for use at nearby institutions. The instrument will be used to trains a student population with large proportions of women and people from ethnic groups that are underrepresented in the chemical sciences. The proportion of students from low-income backgrounds and those who are first-generation college students across the university lend credence to the ability of the project to influence the participation of such students in STEM. The instrument gives students experience using vital instrumentation that they carry with them into their careers.The award of this mass spectrometer is aimed at enhancing research and education at all levels. It especially impacts areas including forensics, medicinal, organic, agricultural and materials chemistry. Research is focused on the screening of chemical profiles and determining characteristics for chemical identification, the identification of biomarkers, drug discovery, development of synthetic products as anti-fungal, anti-inflammatory, and anti-cancer agents, detailed understanding of fermentation and phytochemical transformation, and the sequencing of peptoids.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.