MRI: Acquisition of a Hybrid Quadrupole Mass Spectrometer with an Ultra-High Pressure Chromatograph

该奖项由主要研究仪器和化学仪器项目支持。爱荷华大学的Elizabeth Stone教授及其同事James Gloer， Keri Hornbuckle和David Cwiertny正在获得一台具有电喷雾电离（ESI）功能的混合四极-轨道阱质谱仪，并配备了超高压色谱仪（UPLC）。一般来说，质谱（MS）是用于鉴定和表征复杂样品中少量化学物质的关键分析方法之一。在一个典型的实验中，这些成分流入质谱仪，在那里它们被电离，离子的质量被测量。带有液相色谱仪的仪器可以在混合物到达质谱仪之前将其分离。此次收购加强了大学和地区的研究基础设施。该仪器通过使用这种现代分析技术使不同群体的学生参与研究和研究培训，从而扩大了参与范围。使用该仪器的项目包括爱荷华州斯隆示范指导中心、夏季研究机会项目、爱荷华州生物科学院和美国国家科学基金会支持的可持续水资源开发项目。在环境化学、水处理、生物修复、天然产物、药物化学和食品安全等领域，科学知识的进步有助于实现与社会相关的成果。收购奖加强了各级的研究和教育。它特别影响了分子大气气溶胶的特性，改善了饮用水质量。质谱仪还用于鉴定环境中的类固醇和其他药物的结果以及真菌的生物活性产物。该仪器还为研究人员评估多氯联苯的毒性和补救措施以及表征环境污染物的研究人员提供服务。此外，质谱仪有助于发现新出现的水污染物的转化产物和途径，并研究活跃环境界面的表面膜。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This award is supported by the Major Research Instrumentation and the Chemical Instrumentation Programs. Professor Elizabeth Stone from the University of Iowa and colleagues James Gloer, Keri Hornbuckle and David Cwiertny are acquiring a hybrid quadrupole-Orbitrap mass spectrometer with electrospray ionization (ESI) capabilities and equipped with an ultra high pressure chromatograph (UPLC). In general, mass spectrometry (MS) is one of the key analytical methods used to identify and characterize small quantities of chemical species in complex samples. In a typical experiment, the components flow into a mass spectrometer where they are ionized and the ions' masses are measured. An instrument with a liquid chromatograph can separate mixtures of compounds before they reach the mass spectrometer. The acquisition strengthens the research infrastructure at the University and regional area. The instrument broadens participation by involving diverse groups of students in research and research training using this modern analytical technique. Some of the programs using the instrument are the Iowa Sloan Center for Exemplary Mentoring, Summer Research Opportunities Program, the Iowa Biosciences Academy, and an NSF-supported Sustainable Water Development Program. Advancement of scientific knowledge in the areas of environmental chemistry, water treatment, bioremediation, natural products, medicinal chemistry, and food safety contribute to the achievement of societally-relevant outcomes.The acquisition award enhances research and education at all levels. It especially impacts the characterization of molecular atmospheric aerosols and improves drinking water quality. The mass spectrometer is also used to identify the outcomes of steroids and other pharmaceuticals in the environment and bioactive products from fungi. The instrument also serves researchers evaluating toxicity and remediation of polychlorinated biphenyls as well as those characterizing environmental contaminants. In addition, the mass spectrometer aids in the discovery of transformation products and pathways of emerging water contaminants, and investigations of surface films at active environmental interfaces.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.