MRI: Acquisition of a Hybrid Quadrupole Mass Spectrometer with an Ultra-High Pressure Chromatograph

MRI：购买带有超高压色谱仪的混合四极杆质谱仪

• 批准号: 1919422
• 负责人: Elizabeth Stone
• 金额: $ 30.08万
• 依托单位: University of Iowa
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1919422&HistoricalAwards=false
• 关键词: MRI; Acquisition; Hybrid; Quadrupole; Mass

This award is supported by the Major Research Instrumentation and the Chemical Instrumentation Programs. Professor Elizabeth Stone from the University of Iowa and colleagues James Gloer, Keri Hornbuckle and David Cwiertny are acquiring a hybrid quadrupole-Orbitrap mass spectrometer with electrospray ionization (ESI) capabilities and equipped with an ultra high pressure chromatograph (UPLC). In general, mass spectrometry (MS) is one of the key analytical methods used to identify and characterize small quantities of chemical species in complex samples. In a typical experiment, the components flow into a mass spectrometer where they are ionized and the ions' masses are measured. An instrument with a liquid chromatograph can separate mixtures of compounds before they reach the mass spectrometer. The acquisition strengthens the research infrastructure at the University and regional area. The instrument broadens participation by involving diverse groups of students in research and research training using this modern analytical technique. Some of the programs using the instrument are the Iowa Sloan Center for Exemplary Mentoring, Summer Research Opportunities Program, the Iowa Biosciences Academy, and an NSF-supported Sustainable Water Development Program. Advancement of scientific knowledge in the areas of environmental chemistry, water treatment, bioremediation, natural products, medicinal chemistry, and food safety contribute to the achievement of societally-relevant outcomes.The acquisition award enhances research and education at all levels. It especially impacts the characterization of molecular atmospheric aerosols and improves drinking water quality. The mass spectrometer is also used to identify the outcomes of steroids and other pharmaceuticals in the environment and bioactive products from fungi. The instrument also serves researchers evaluating toxicity and remediation of polychlorinated biphenyls as well as those characterizing environmental contaminants. In addition, the mass spectrometer aids in the discovery of transformation products and pathways of emerging water contaminants, and investigations of surface films at active environmental interfaces.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器和化学仪器计划支持。来自爱荷华州大学的Elizabeth Stone教授及其同事James Gloer、Keri Hornbuckle和大卫Cwiertny正在购买一种具有电喷雾电离（ESI）能力并配备超高压色谱仪（UPLC）的混合四极杆-轨道阱质谱仪。 一般来说，质谱（MS）是用于识别和表征复杂样品中少量化学物质的关键分析方法之一。在一个典型的实验中，成分流入质谱仪，在那里它们被电离，并测量离子的质量。 带有液相色谱仪的仪器可以在化合物到达质谱仪之前将其分离。此次收购加强了大学和地区的研究基础设施。该工具通过利用这一现代分析技术使不同群体的学生参与研究和研究培训，扩大了参与。使用该仪器的一些项目包括爱荷华州斯隆示范指导中心、夏季研究机会项目、爱荷华州生物科学学院和NSF支持的可持续水资源开发项目。 环境化学、水处理、生物修复、天然产物、药物化学和食品安全领域的科学知识的进步有助于实现社会相关成果。该收购奖加强了各级研究和教育。它特别影响分子大气气溶胶的表征，并改善饮用水质量。质谱仪还用于识别环境中类固醇和其他药物的结果以及真菌的生物活性产物。该仪器还为研究人员评估多氯联苯的毒性和补救以及表征环境污染物的研究人员提供服务。此外，质谱仪还有助于发现新出现的水污染物的转化产物和途径，以及对活跃环境界面表面膜的研究。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

White Rot Fungi Produce Novel Tire Wear Compound Metabolites and Reveal Underappreciated Amino Acid Conjugation Pathways.

• DOI: 10.1021/acs.estlett.2c00114
• 发表时间: 2022-05-10
• 期刊: ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
• 影响因子: 10.9
• 作者: Wiener, Erica A.;LeFevre, Gregory H.
• 通讯作者: LeFevre, Gregory H.

Assessment of Polychlorinated Biphenyls and Their Hydroxylated Metabolites in Postmortem Human Brain Samples: Age and Brain Region Differences.

• DOI: 10.1021/acs.est.2c00581
• 发表时间: 2022-07-05
• 期刊: ENVIRONMENTAL SCIENCE & TECHNOLOGY
• 影响因子: 11.4
• 作者: Li, Xueshu;Hefti, Marco M.;Marek, Rachel F.;Hornbuckle, Keri C.;Wang, Kai;Lehmler, Hans-Joachim
• 通讯作者: Lehmler, Hans-Joachim

Rapid plant uptake of isothiazolinone biocides and formation of metabolites by hydroponic Arabidopsis.

水培拟南芥植物快速吸收异噻唑啉酮杀菌剂并形成代谢物。

• DOI: 10.1039/d2em00178k
• 发表时间: 2022
• 期刊: Environmental science. Processes & impacts
• 作者: Muerdter,ClaireP;Powers,MeganM;Chowdhury,Sraboni;Mianecki,AlyssaL;LeFevre,GregoryH
• 通讯作者: LeFevre,GregoryH

Acid- and Base-Mediated Hydrolysis of Dichloroacetamide Herbicide Safeners.

• DOI: 10.1021/acs.est.1c05958
• 发表时间: 2022-01-04
• 期刊: Environmental science & technology
• 影响因子: 11.4
• 作者: McFadden ME;Patterson EV;Reber KP;Gilbert IW;Sivey JD;LeFevre GH;Cwiertny DM
• 通讯作者: Cwiertny DM