MRI: Acquisition of Multiscale Pore Size Analyzers for Research and Education

MRI：购买多尺度孔径分析仪用于研究和教育

• 批准号: 2216061
• 负责人: Maryam Mobed-Miremadi
• 金额: $ 33.18万
• 依托单位: Santa Clara University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2216061&HistoricalAwards=false
• 关键词: MRI; Acquisition; Multiscale; Pore; Size

As multiscale applications become an integral part of humanity’s challenges, it is important for students to gain an understanding of structure-property relationships. The measured parameters integrated into mathematical frameworks by students and faculty mentors will facilitate a faster response and greater resilience against health and climate crises. A subset of solutions enabled by equipment acquisition across inter-disciplinary fields is as follows: a) design of artificial membranes to address biomanufacturing challenges during pandemics; b) use of artificial intelligence to identify defective biological filters; c) paper-based assays to detect pathogens, and, d) nanoparticle characterization to combat water pollution. Other emerging research areas include cancer diagnostics and renewable energy. Sample acquisition times with the proposed equipment are 30 min suitable for a three-hour laboratory session, a rapid and economical solution when compared to costly multi-session imaging-based pedagogic methods. The proposed equipment will be integrated in several courses and laboratories across STEM, namely in materials characterization and immunology initiatives. A total of 200 students from a demographically diverse population will benefit yearly from this effort. Outreach efforts will extend to West Valley Community College and local high schools where students will be introduced to nanotechnology through online instruction and hands-on experimentation. In the heart of Silicon Valley, student/faculty publications will empower academic and industrial translational opportunities, resulting in a skilled and motivated workforce accelerating the nation’s global competitiveness.State-of-the-art instrumentation to investigate surface, bulk and interphase architecture will be used to address gaps in knowledge across multiscale applications at the biomaterials, health and climate nexus. This will provide an understanding of structure property relationships, specifically in terms of pore size and porosity. Both micropores ( 2nm) and macropores (50 nm) will be quantified. Porosity will be indirectly determined by density. The generation of knowledge through experimentation with modern equipment and a first principle-based approach to problem-solving will enable robust scaling. In parallel, a material database featuring collected data from characterization tests will be constructed as a basis for statistical learning models and simulations. The data from this project will be disseminated so that other engineers and scientists can also use these training sets.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

随着多尺度应用成为人类挑战的一个组成部分，对学生了解结构-性质关系是很重要的。由学生和教师导师将测量参数整合到数学框架中，将有助于更快地应对健康和气候危机，并提高应对能力。通过跨学科领域的设备采购，可以实现以下解决方案：A)设计人工膜，以应对大流行期间的生物制造挑战；B)使用人工智能来识别有缺陷的生物过滤器；C)检测病原体的纸质分析，以及d)纳米颗粒表征以对抗水污染。其他新兴研究领域包括癌症诊断和可再生能源。与昂贵的基于多会话成像的教学方法相比，该设备的样品采集时间为30分钟，适用于3小时的实验室会话，这是一种快速而经济的解决方案。拟议的设备将集成到STEM的几个课程和实验室中，即材料表征和免疫学计划。每年将有200名来自不同人口的学生受益于这一努力。推广工作将扩展到西谷社区大学和当地的高中，学生们将通过在线教学和动手实验来了解纳米技术。在硅谷的中心，学生/教师的出版物将为学术和工业转化提供机会，从而产生一支熟练和积极的劳动力队伍，加速国家的全球竞争力。用于研究表面、体和相间结构的最先进仪器将用于解决生物材料、健康和气候关系的多尺度应用中的知识空白。这将提供对结构性质关系的理解，特别是在孔隙大小和孔隙度方面。微孔（2nm）和大孔（50nm）都将被量化。孔隙度将由密度间接决定。通过现代设备的实验和基于第一原理的解决问题的方法来产生知识，将实现稳健的扩展。同时，将建立一个材料数据库，其中包括从特性测试中收集的数据，作为统计学习模型和模拟的基础。该项目的数据将被传播，以便其他工程师和科学家也可以使用这些训练集。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。