MRI: Acquisition of an Automated X-Ray Scattering Instrument for in situ Multiscale Studies

MRI：获取用于原位多尺度研究的自动 X 射线散射仪器

• 批准号: 2117523
• 负责人: Rebecca Taylor
• 金额: $ 99.22万
• 依托单位: Carnegie-Mellon University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2117523&HistoricalAwards=false
• 关键词: MRI; Acquisition; Automated; Ray; Scattering

The development of cutting-edge nanostructured materials for applications like smart surfaces, batteries, and synthetic tissues requires highly interdisciplinary teams as well as tools that can characterize materials across scales. Advanced functional materials have the potential to drive advances in sensing (for uses such as environmental monitoring, disease diagnosis and advanced manufacturing), energy storage for enhanced energy sustainability and robotics (with applications ranging from providing support to amputees and stroke victims to disaster response). The behavior of materials that have nanostructural features from Angstroms to hundreds of nanometers in size must be measured under realistic conditions to characterize their structural properties during use. This Major Research Instrumentation (MRI) award will support the acquisition of a Small to Wide Angle X-ray Scattering (SAXS/WAXS) system at Carnegie Mellon University (CMU) to address these needs, enabling high-throughput studies at a variety of length scales and under a variety of stimulation conditions. By customizing the system to enable high-throughput and robotic control of experiments, this instrument will facilitate the broadening of participation in X-ray scattering research to users across science and engineering. Through an “Initiative for fully-automated high-throughput SAXS/WAXS” and annual meetings of the Western PA SAXS/WAXS Interest Group, this project will seed new collaborations that enable next-generation robotics applications and developing methodologies for machine learning-based discovery. Short courses and case studies in existing courses will support the integration of research and teaching, and outreach on SAXS/WAXS will target women and underrepresented groups. Ease of use, automation and remote operation capabilities will facilitate utilization at a national level.The research enabled by this instrumentation seeks to link material function to structure from the atomic to micron scales. The SAXS/WAXS system will enable researchers to conduct in situ and in operando studies across these scales to address a variety of important fundamental knowledge gaps. Specific goals include the use of the instrument to develop research contributions in the following areas: (1) solution-dependent conformation and dynamics of responsive nucleic acid nanosystems, (2) understanding and mitigating the structural evolutions in lithium ion battery electrodes that eventually lead to damage and catastrophic battery failure, (3) linking structure to function for novel antibacterial peptides, (4) elucidating the interplay between ion clustering and molecular packing/morphology of polymer matrix in governing the efficient transport in ion-transport membranes, and (5) the development of novel copolymer-based architectures in which lock-and-key interactions facilitate self-healing properties.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

用于智能表面，电池和合成组织等应用的尖端纳米结构材料的开发需要高度跨学科的团队以及可以在范围内表征材料的工具。先进的功能材料有可能推动感应的进步（用于环境监测，疾病诊断和高级制造），能源存储，以增强能源可持续性和机器人技术（应用程序从向截肢者提供支持，滥用术语到灾难反应）。必须在现实条件下测量具有纳米结构特征从埃埃斯特群到数百个纳米的材料的行为，以表征其在使用过程中的结构特性。这项主要的研究仪器奖（MRI）奖将支持卡内基梅隆大学（CMU）在卡内基梅隆大学（CMU）中获得小到广角X射线散射（SAXS/WAXS）系统，以满足这些需求，从而在各种长度尺度和各种模拟条件下都能在各种长度尺度上进行高通量研究。通过自定义系统以实现实验的高通量和机器人控制，该工具将促进向跨科学和工程的用户参与X射线散射研究的参与。通过“全自动高通量SAX/蜡的计划”和Western PA SAXS/WAXS兴趣小组的年度会议，该项目将播种新的合作，以实现下一代机器人应用程序和开发基于机器学习的发现方法。现有课程中的简短课程和案例研究将支持研究和教学的整合，以及对萨克斯/蜡的宣传将以妇女和代表性不足的群体为目标。易用性，自动化和远程操作功能将在国家一级支持利用。该仪器启用的研究试图将材料功能与从原子量到微米尺度的结构联系起来。 SAXS/WAXS系统将使研究人员能够在这些量表上进行原位和歌剧研究，以解决各种重要的基本知识差距。 Specific goals include the use of the instrument to develop research contributions in the following areas: (1) solution-dependent consideration and dynamics of responsive nuclear acid nanosystems, (2) understanding and mitigating the structural evolutions in Lithium ion battery electrodes that sometimes lead to damage and catastrophic battery failure, (3) linking structure to function for novel antibacterial peppers, (4) elucidating the interplay between ion clustering and聚合物矩阵的分子包装/形态在管理离子传输机制的有效运输方面，以及（5）基于新型共聚物的新型建筑的发展，其中锁定互动促进了自我控制属性，有助于自我控制属性。该奖项通过评估了NSF的法定任务，并通过评估了CR CRACTIARIA的支持，并反映出了cr Intellia and Intellitial and Foundation and Foundation的支持。