Genomics at the Shoreline

该奖项将在华盛顿大学星期五港实验室(FHL)建立一个海洋基因组学中心，方法是将一座未得到充分利用的实验室建筑改建为一个潮湿的实验室，该实验室已经配备了流动海水系统，其中有干燥的程序空间，其中包含分子基因组学的现代工具-纳米孔测序、扩增、纯化和质量保证的工具。新的实验室将吸引新的研究人员，将允许现有的研究人员扩大他们在FHL的工作，并将被用作参与涉及基因组研究的FHL计划的下一代生物学家的培训中心。易于修改的实验室配置还可以用于有15-20人参加的短期培训研讨会。该中心将为了解生物基因组和物候组之间的关系做出贡献。一个具有DNA条形码、全基因组测序、实时聚合酶链式反应和疾病检测能力的实验室将大大扩展FHL在生物成像、CT扫描库、学徒、研讨会和表型组学研究本科生培训计划方面的现有优势。FHL的现场分子生物学实验室将吸引新的主要研究人员和研究生，并保持其作为研究机构的相关性。投资于FHL的分子生物学研究基础设施将对人类健康产生更广泛的影响，并将有助于沟通分子、生物形态和海洋之间的联系。有关星期五港湾实验室的更多信息，请参阅https://fhl.uw.edu/.This奖项，该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

This award will establish a Marine Genomics Center at the University of Washington’s Friday Harbor Laboratories (FHL) by remodeling an underutilized lab building, already equipped with a flow-through seawater system, into a wet lab with dry procedure spaces containing the modern tools for molecular genomics – tools for nanopore sequencing, amplification, purification, and quality assurance. The new lab will attract new researchers, will allow established researchers to expand their work at FHL, and will be used as a training center for the next generation of biologists participating in FHL programs involving genomics research. Having the lab configuration easily modified will also enable its use forshort-term training workshops with 15-20 participants. This Center will contribute to research on understanding the relationship between organismal genomes and phenomes. A lab with the capacity for DNA barcoding, whole genome sequencing, real time PCR, and disease detection will significantly expand on FHL’s existing strengths in bioimaging, libraries of CT scans, apprenticeships, workshops, and undergraduate training programs in phenomics research. An onsite molecular biology lab at FHL will attract new principal investigators and graduate students and maintain its relevance as a research institution. Investing in infrastructure for molecular biology research at FHL will have broader impacts in human health and will help communicate the connections between molecules, organismal morphology, and the ocean. For more information about Friday Harbor Laboratories, see https://fhl.uw.edu/.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.