MCA: Validating Patterns of Bone Functional Adaptation in Living Humans

MCA：验证活人骨功能适应模式

• 批准号: 2219849
• 负责人: Libby Cowgill
• 金额: $ 29.57万
• 依托单位: University of Missouri-Columbia
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2219849&HistoricalAwards=false
• 关键词: MCA; Validating; Patterns; Bone; Functional

Bone is a living tissue that can adapt and change in response to an individual’s behavior and environment. Skeletal data therefore are used in bioarchaeology, paleoanthropology, and forensic anthropology to infer habitual activities such as mobility, locomotor type, weapon use, and subsistence strategy. In this Mid-Career Advancement project, the principal investigator aims to improve such inferences through additional examination and validation of relationships among bone, muscle, and activity patterns using imaging and behavioral data from living individuals. This research requires advanced professional development in analysis of CT scans, cutting-edge statistical methods, and enhanced scientific communication, obtained through a new research partnership, quantitative coursework, and outreach training workshops. The project supports training in new research methods and science communication for a female Associate Professor in a field where women are still under-represented at senior levels, as well as curriculum development and associated opportunities for student research and training. The project advances foundational research in bone skeletal biology about the relationships between hard tissue, soft tissue, and mechanical loading in living humans. Three aims are explored using CT data from living individuals. First, the relationship between muscle size and bone strength in different regions of the body is investigated to establish if human bone strength covaries more with localized muscle forces or is systemically dictated by other factors. Second, the covariation between bone strength and self-reported and documented activity patterns is evaluated. Third, path analysis is used to explore possible causal models between loading, muscular size, and bone strength. Through partnership with an expert in functional anatomy and image analysis, the principal investigator gains advanced research skills and expand collaborations. The project specifically meets several goals of the Mid-Career Advancement program, including enabling convergent research, enhancing strategic workforce development, and fostering risk taking.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

骨骼是一种活组织，可以根据个人的行为和环境进行调整和改变。因此，骨骼数据被用于生物考古学、古人类学和法医人类学，以推断习惯性活动，如机动性、运动类型、武器使用和生存策略。在这个职业发展中期项目中，首席研究人员的目标是通过使用活着的个人的成像和行为数据对骨骼、肌肉和活动模式之间的关系进行额外的检查和验证，来改进这些推断。这项研究需要通过新的研究伙伴关系、量化课程和外展培训讲习班，在CT扫描分析、尖端统计方法和加强科学交流方面进行高级专业发展。该项目支持在妇女在高层任职人数仍然不足的领域对一名女性副教授进行新研究方法和科学交流方面的培训，以及为学生研究和培训制定课程和提供相关机会。该项目推进了关于活体人类硬组织、软组织和机械负荷之间关系的骨骨骼生物学的基础研究。使用活着的个体的CT数据来探索三个目标。首先，研究身体不同部位的肌肉大小和骨骼强度之间的关系，以确定人类骨骼强度是更多地与局部肌肉力量相关，还是由其他因素系统地决定。其次，评估骨强度与自我报告和记录的活动模式之间的协变性。第三，路径分析被用来探索负荷、肌肉大小和骨强度之间可能的因果模型。通过与功能解剖和图像分析专家的合作，首席研究员获得了先进的研究技能，并扩大了合作。该项目特别符合职业中期推进计划的几个目标，包括促进融合研究、加强战略性劳动力发展和培养冒险精神。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。