Experimental and Computational Investigation of Mechanisms Governing Soft Tissue Interfaces

软组织界面控制机制的实验和计算研究

• 批准号: 2225174
• 负责人: Corinne Henak
• 金额: $ 41.17万
• 依托单位: University of Wisconsin-Madison
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2025-07-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2225174&HistoricalAwards=false
• 关键词: Experimental; Computational; Investigation; Mechanisms; Governing

This grant will identify the mechanisms that govern mechanical behavior at soft tissue interfaces. Soft tissue interfaces are where two soft biological materials come together. These occur naturally, such as at the interface between muscle and tendon. These also occur in surgical and healing contexts, such as in focal cartilage repair. These interfaces are often spatially heterogeneous, which means that the stiffness and softness of the material varies with specific location. This has been shown using imaging techniques such as microscopy. How this heterogeneity affects the mechanical behavior across the interface is not known. When two soft tissues come together, their mechanical interactions can arise from friction, adhesion, and from the growth of new tissue across the interface. This work will first conduct experiments to measure spatial heterogeneity of the mechanical behavior at soft tissue interfaces. The work will then build computational models to identify the mechanisms governing this behavior. The results of this research will provide new fundamental insight into soft tissue interfaces. These insights can be used to improve surgical repair of soft tissue damage and can be used to design bio-inspired soft robotics. The results from this research will be shared with the broader public at outreach events, and will be shared with undergraduate and graduate students. Soft material interfaces are relevant to repair and regeneration of soft tissues, and to the application of soft robotics. The phenomena governing the mechanics at soft tissue interfaces is incompletely understood. This project will use a model system of in vitro cartilage-cartilage integration to experimentally and computationally probe those phenomena. The research team will conduct experiments to quantify spatially variant displacement at the cartilage-cartilage interface. In tandem, the research team will conduct experiments to quantify the bulk behavior, frictional behavior, adhesive behavior, swelling behavior and neocartilage material behavior. Subsequently, finite element models will be generated using the quantified behavior to interpret spatially variant displacement data. Models are expected to reveal the fundamental phenomena governing soft tissue interfaces. Results from this research will be integrated into K12, undergraduate, graduate, and broader public education.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该基金将确定软组织界面的机械行为的机制。软组织界面是两种软生物材料结合在一起的地方。这些是自然发生的，例如在肌肉和肌腱之间的界面。这些也发生在手术和愈合的情况下，如在局灶性软骨修复。这些界面通常在空间上是不均匀的，这意味着材料的刚度和柔软度随特定位置而变化。这已经使用成像技术如显微镜显示。这种不均匀性如何影响界面上的力学行为尚不清楚。当两个软组织结合在一起时，它们的机械相互作用可能来自摩擦、粘附和新组织在界面上的生长。这项工作将首先进行实验，以测量在软组织界面的力学行为的空间异质性。 然后，这项工作将建立计算模型，以确定控制这种行为的机制。这项研究的结果将为软组织界面提供新的基本见解。这些见解可用于改善软组织损伤的手术修复，并可用于设计生物启发的软机器人。这项研究的结果将在外联活动中与更广泛的公众分享，并将与本科生和研究生分享。软材料界面与软组织的修复和再生以及软机器人的应用有关。在软组织界面的力学现象还没有完全理解。本计画将使用一个体外软骨-软骨整合的模型系统，以实验和计算的方式来探讨这些现象。研究小组将进行实验，以量化软骨-软骨界面的空间变化位移。同时，研究小组将进行实验，以量化体积行为，摩擦行为，粘附行为，溶胀行为和新软骨材料行为。随后，将使用量化行为生成有限元模型，以解释空间变化的位移数据。模型有望揭示软组织界面的基本现象。这项研究的结果将被整合到K12，本科，研究生和更广泛的公共教育中。这个奖项反映了NSF的法定使命，并被认为值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估来支持。