I-Corps: An Innovative Technology for Environmental Exposure and Respiratory Response Assessment

I-Corps：环境暴露和呼吸反应评估的创新技术

• 批准号: 2226332
• 负责人: Maryam Karimi
• 金额: $ 5万
• 依托单位: University of Alabama at Birmingham
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2226332&HistoricalAwards=false
• 关键词: Corps; Innovative; Technology; Environmental; Exposure

The broader impact/commercial potential of this I-Corps project is the development of compact, wearable, and user-friendly lung health monitoring device that can keep patients out of emergency rooms and hospital beds and in the comfort of their homes. The first commercial applications will focus on chronic obstructive pulmonary disease (COPD), asthma, and respiratory-compromised patients whose symptoms are not well controlled and have severe breakthrough attacks requiring medical attention. These patients are most likely to be motivated to use wearable device for monitoring. This market may be expanded to patients with other respiratory diseases and potentially to COVID-19 and long-COVID. The device has the potential to empower patients to better monitor their respiratory health and change behaviors resulting in immediate health benefits. There is also the potential for an occupational safety market to monitor ambient air quality in the workplace.This I-Corps project is based on the development of a wearable environmental exposure and lung health monitoring device. The first prototypes have been designed and developed and are currently in an inpatient trial at the University of Alabama at Birmingham Lung Health Center. These prototype devices are collecting data and connecting COPD and asthma patients to their health care providers which will allow for a reduction of emergency room visits and hospital time. This technology is a wearable device technology being developed to provide continuous monitoring of a patient’s ambient environment (nitrogen dioxide (NO2), ozone (O3), sulphur dioxide (SO2), and particular matter (PM) along with air temperature and relative humidity), physical activity, body temperature, blood oxygen level, respiratory function, the pace of movement, and geographic location outside of the hospital system. The respiratory function data is assessed using a peak flow meter. A built-in movement tracker allows real-time spatial-temporal resolution data to assess the level of physical activity. The collection of an individual’s global positioning system (GPS) coordinates enables location monitoring in association with activity parameters for precise sampling intervals. The data will be be displayed in a user-friendly app to the individual, to help educate them on respiratory health and identify potential triggers and to their health care provider for assessment and intervention.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该 I-Corps 项目更广泛的影响/商业潜力是开发紧凑、可穿戴且用户友好的肺部健康监测设备，可以让患者远离急诊室和医院病床，并在舒适的家中度过。首批商业应用将集中于慢性阻塞性肺病（COPD）、哮喘和呼吸系统受损的患者，这些患者的症状没有得到很好的控制，并且有严重的突破性发作，需要医疗护理。这些患者最有可能被激励使用可穿戴设备进行监测。该市场可能会扩展到患有其他呼吸系统疾病的患者，并可能扩展到 COVID-19 和长期 COVID 患者。该设备有潜力使患者能够更好地监测他们的呼吸健康并改变行为，从而带来立竿见影的健康益处。职业安全市场也有潜力监测工作场所的环境空气质量。这个 I-Corps 项目基于可穿戴环境暴露和肺部健康监测设备的开发。第一个原型已经设计和开发出来，目前正在阿拉巴马大学伯明翰肺健康中心进行住院试验。这些原型设备正在收集数据，并将慢性阻塞性肺病和哮喘患者与其医疗保健提供者联系起来，这将减少急诊室就诊次数和住院时间。该技术是一种可穿戴设备技术，旨在连续监测患者的周围环境（二氧化氮（NO2）、臭氧（O3）、二氧化硫（SO2）和颗粒物（PM）以及气温和相对湿度）、体力活动、体温、血氧水平、呼吸功能、运动速度和医院系统外的地理位置。使用峰值流量计评估呼吸功能数据。内置运动跟踪器允许实时时空分辨率数据来评估身体活动水平。收集个人的全球定位系统 (GPS) 坐标可实现与活动参数相关的位置监控，以实现精确的采样间隔。这些数据将在用户友好的应用程序中显示给个人，以帮助他们了解呼吸健康并识别潜在的触发因素，并提供给他们的医疗保健提供者进行评估和干预。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力优点和更广泛的影响审查标准进行评估，被认为值得支持。